Development of manufacturing method for rapidly disintegrating oral tablets using the crystalline transition of amorphous sucrose

International Journal of Pharmaceutics

Volumn 320, Issue 1-2, 2006, Pages 71-78

  Sugimoto, Masaaki ^a   Narisawa, Shinji ^a   Matsubara, Koji ^a   Yoshino, Hiroyuki ^a   Nakano, Minoru ^b   Handa, Tetsurou ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Amorphous sucrose; Crystallization; Fluidized bed granulation; Rapidly disintegrating oral tablet; Tensile strength

Indexed keywords

MANNITOL; SUCROSE;

ARTICLE; CRYSTALLIZATION; DRUG GRANULATION; DRUG MANUFACTURE; DRUG STORAGE; FLUIDIZED BED; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET FORMULATION; TEMPERATURE SENSITIVITY; TENSILE STRENGTH; THERMAL ANALYSIS; WATER CONTENT; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG STORAGE; EXCIPIENTS; MANNITOL; POROSITY; SOLUBILITY; SUCROSE; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TENSILE STRENGTH; TIME FACTORS;

EID: 33746405104     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.04.004     Document Type: Article

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