The use of mercury porosimetry in assessing the effect of different binders on the pore structure and bonding properties of tablets

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 52, Issue 2, 2001, Pages 237-247

  Mattsson, Sofia ^a   Nyström, Christer ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Binder; Deformability; Interparticulate bonds; Mercury porosimetry; Pore size distribution; Tablet strength

Indexed keywords

BICARBONATE; BINDER; EXCIPIENT; GELATIN; MACROGOL 20000; MACROGOL 3000; MERCURY; SEPISTAB ST 200; SODIUM CHLORIDE; STARCH; UNCLASSIFIED DRUG;

ARTICLE; BINARY MIXTURE; CONTROLLED STUDY; DRUG MIXTURE; MEASUREMENT; PHYSICAL PARAMETERS; POWDER; TABLET; TABLET POROSITY; TENSILE STRENGTH;

MERCURY; POLYETHYLENE GLYCOLS; POROSITY; POWDERS; SURFACE-ACTIVE AGENTS; TABLETS;

EID: 0034886078     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00163-1     Document Type: Article

References (31)

1. Compression strength of porous sintered alumina and zirconia
2. Studies on tableting properties of lactose. Part 2. Consolidation and compaction of different types of crystalline lactose
3. Studies on tableting properties of lactose. Part 3. The consolidation behaviour of sieve fractions of crystalline α-lactose monohydrate
4. The effect of particle fragmentation and deformation on the interparticulate bond formation process during powder compaction
5. Relationship between breaking force and pore structure of lactose, glucose and mannitol tablets
6. Evaluation of the effect of addition of polyethylene glycols of differing molecular weights on the mechanical strength of sodium chloride and sodium bicarbonate tablets
7. Evaluation of strength-enhancing factors of a ductile binder in direct compression of sodium bicarbonate and calcium carbonate powders
8. Evaluation of critical binder properties affecting the compactibility of binary mixtures
9. Evaluation of a permeametry technique for surface area measurements of coarse particulate materials
10. Studies on direct compression of tablets. X. Measurement of tablet surface area by permeamtry
11. The prediction of the tensile strength of tablets
12. Measurement of axial and radial tensile strength of tablets and their relation to capping
13. Macropore-size distributions in some typical porous substances
14. Mercury porosimetry in pharmaceutical technology
15. Studies on direct compression of tablets. XVI. The use of surface area measurements for evaluation of bonding surface area in compressed powders
16. The effect of an increase in chain length on the mechanical properties of polyethylene glycols
17. The properties of tablets containing microcrystalline cellulose
18. Tensile strength of tablets containing two materials with a different compaction behaviour
19. The characterisation of the mechanical properties of microcrystalline cellulose: a fracture mechanics approach
20. Agglomerate strength
21. The relationship between the fracture properties, tensile strength and critical stress intensity factor of organic solids and their molecular structure
22. Studies on direct compression of tablets. XXI. Investigation of bonding mechanisms of some directly compressed materials by strength characterization in media with different dielectric constants (relative permittivity)
23. Compaction and measurement of tablets in liquids with different dielectric constants for determination of bonding mechanisms - evaluation of the concept
24. Effect of particle size and compaction load on interparticulate bonding structure for some pharmaceutical materials studied by compaction and strength characterization in butanol
25. Bonding surface area and bonding mechanism - two important factors for the understanding of powder compactability
26. Use of tablet tensile strength adjusted for surface area and mean interparticulate distance to evaluate dominating bonding mechanisms
27. Assessing tablet bond types from structural features that affect tablet tensile strength
28. The effect of milling and addition of dry binder on the interparticulate bonding mechanisms in sodium chloride tablets