Mephenytoin as a probe for CYP2C19 phenotyping: Effect of sample storage, intra-individual reproducibility and occurrence of adverse events

British Journal of Clinical Pharmacology

Volumn 51, Issue 5, 2001, Pages 471-474

  Tamminga, Wim J ^a,b   Wemer, Johan ^c   Oosterhuis, Berend ^a   Wieling, Jaap ^d   Touw, Daan J ^e   De Zeeuw, Rokus A ^b   De Leij, Lou F M H ^b   Jonkman, Jan H G ^b  

^a PRA International USA   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c ASTRAZENECA R AND D   (Sweden)

^d Meditech Center   (Netherlands)

^e Central Hospital Pharmacy   (Netherlands)

Author keywords

CYP2C19; Mephenytoin; Phenotyping

Indexed keywords

ACID; CYTOCHROME P450 2C19; DRUG METABOLITE; MEPHENYTOIN;

ABDOMINAL DISCOMFORT; ANALYTIC METHOD; ANALYTICAL ERROR; ARTICLE; CONTROLLED STUDY; DROWSINESS; DRUG METABOLISM; DRUG SAFETY; DRUG STORAGE; FEMALE; GENE PROBE; GENETIC VARIABILITY; HEADACHE; HUMAN; INCIDENCE; INSOMNIA; ISOMER; MALE; MOLECULAR CLONING; NAUSEA; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; REPRODUCIBILITY; STEREOCHEMISTRY; URINALYSIS; VERTIGO;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG STABILITY; DRUG STORAGE; FEMALE; HUMANS; MALE; MEPHENYTOIN; MIXED FUNCTION OXYGENASES; PHENOTYPE; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY;

EID: 0034856388     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2001.01331.x     Document Type: Article

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