Swelling characteristics and drug delivery properties of nifedipine-loaded pH sensitive alginate-chitosan hydrogel beads

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 86, Issue 2, 2008, Pages 493-500

  Dai, Ya Ni ^a   Li, Ping ^a   Zhang, Jun Ping ^b   Wang, Ai Qin ^b   Wei, Qin ^a  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Chitosan; Drug delivery properties; Nifedipine; pH sensitive hydrogel beads; Swelling characteristics

Indexed keywords

ALGINATE; AMINES; CARBOXYLIC ACIDS; CHEMOTHERAPY; CHITIN; CHITOSAN; COAGULATION; COLLOIDS; DRUG DELIVERY; DRUG DOSAGE; ESTERS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GELATION; LEAKAGE (FLUID); PH SENSORS; PHOTORESISTS; POLYMERS; PYRIDINE; SURFACE STRUCTURE;

CARRIER (CO); CHITOSAN HYDROGEL BEADS; GASTRIC FLUIDS; HYDROGEL; IN VITRO RELEASES; INTESTINAL TRACTS; IONIC GELATION METHOD; NIFEDIPINE; PH SENSITIVITY; PH-SENSITIVE; PHOSPHATE BUFFER SOLUTION (PBS); POLYELECTROLYTE COMPLEX (PEC); SWELLING BEHAVIORS; SWELLING CHARACTERISTICS;

HYDROGELS;

ALGINIC ACID; BUFFER; CHITOSAN; DRUG CARRIER; NIFEDIPINE; PHOSPHATE; POLYELECTROLYTE;

ARTICLE; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG RELEASE; GELATION; HYDROGEL; INFRARED SPECTROSCOPY; INTESTINE; PH; SCANNING ELECTRON MICROSCOPY; SIMULATION; STOMACH JUICE; SURFACE PROPERTY;

ALGINATES; BUFFERS; CHITOSAN; DRUG DELIVERY SYSTEMS; GASTRIC JUICE; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGEL; HYDROGEN-ION CONCENTRATION; INTESTINES; MICROSPHERES; NIFEDIPINE; WETTABILITY;

EID: 47949084785     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31046     Document Type: Article

References (46)

1. Kaplan DL, Wiley BJ, Mayer JM, Arcidiacono S, Keith J, Lombardi SJ, Ball D, Allen AL. Biomedical Polymers. In: Shalaby SW, editor. Biomedical Polymers. New York: Hanser Publishers; 1994. pp 189-212.
2. Gombotz WR, Wee SF. Protein release from alginate matrices. Adv Drug Deliv Rev 1998;31:267-285.
3. Ilium L. Chitosan and its use as a pharmaceutical excipient. Pharm Res 1998;15:1326-1331.
4. Chatelet C, Damour O, Domard A. Influence of the degree of acetylation on some biological properties of chitosan films. Biomaterials 2001;22:261-268.
5. GåserØd O, SmidsrØd O, Skjåk-Bræk G. Microcapsules of alginate-chitosan-I. A quantitative study of the interaction between alginate and chitosan. Biomaterials 1998;19:1815-1825.
6. GåserØd O, Sannes A, Skjåk-Bræk G. Microcapsules of alginate-chitosan-II. A study of capsule stability and permeability. Biomaterials 1999;20:773-783.
7. Mi FL, Shyu SS, Chen CT, Schoung JY. Porous chitosan microsphere for controlling the antigen release of newcastle disease vaccine: Preparation of antigen-adsorbed microsphere and in vitro release. Biomaterials 1999;20:1603-1612.
8. Shu XZ, Zhu KJ. A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery. Int J Pharm 2000;201:51-58.
9. Murano E. Use of natural polysaccharides in the microencapsulation Techniques. J Appl Ichthyol 1998;14:245-249.
10. Smidsrod O, Skjakbraek G. Alginate as immobilization matrix for Cells. Trends Biotechnol 1990;8:71-78.
11. Becherán-Marón L, Peniche C, Argüelles-Monal W. Study of the interpolyelectrolyte reaction between chitosan and alginate: Influence of alginate composition and chitosan molecular weight. Int J Biol Macromol 2004;34:127-133.
12. Mi FL, Sung HW, Shyu SS. Drug release from chitosan-alginate complex beads reinforced by a naturally occurring cross-linking agent. Carbohydr Polym 2002;48:61-72.
13. Miyazaki S, Nakayama A, Oda M, Takada M, Attwood D. Drug release from oral mucosal adhesive tablets of chitosan and sodium alginate. Int J Pharm 1995;118:257-263.
14. Murata Y, Miyamoto E, Kawashima S. Additive effect of chondroitin sulfate and chitosan on drug release from calcium-induced alginate gel beads. Int J Pharm 1996;38:101-108.
15. Ribeiro AJ, Silva C, Ferreira D, Veiga F. Chitosan-reinforced alginate microspheres obtained through the emulsification/internal gelation technique. Eur J Pharm Sci 2005;25:31-40.
16. Zhou SB, Deng XM, Li XH. Investigation on a novel corecoated microspheres protein delivery system. J Control Release 2001;75:27-36.
17. Anal AK, Stevens WF. Chitosan-alginate multilayer beads for controlled release of ampicillin. Int J Pharm 2005;290:45-54.
18. Gotoh T, Matsushima K, Kikuchi KI. Preparation of alginate-chitosan hybrid gel beads and adsorption of divalent metal ions. Chemosphere 2004;55:135-140.
19. Lin YH, Liang HF, Chung CK, Chen MC, Sung HW. Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs. Biomaterials 2005;26:2105-2113.
20. GåsevØd O, Jolliffe IG, Hampson FC, Detterma PW, Skjåk-Bræk G. The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan. Int J Pharm 1998;175:237-246.
21. Tapia C, Escobar Z, Costa E, Sapag-Hagar J, Valenzuela F, Basualto C, Gai MN, Yazdani-Pedram M. Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems. Eur J Pharm Biopharm 2004;57:65-75.
22. González-Rodríguez ML, Holgado MA, Sánchez-Lafuente C, Rabasco AM, Fini A. Alginate/chitosan particulate systems for sodium diclofenac release. Int J Pharm 2002;232:225-234.
23. Murata Y, Toniwa S, Miyamoto E, Kawashima S. Preparation of alginate gel beads containing chitosan salt and their function. Int J Pharm 1999;176:265-268.
24. Murata Y, Kontani Y, Ohmae H, Kawashima S. Behavior of alginate gel beads containing chitosan salt prepared with water-soluble vitamins. Eur J Pharm Biopharm 2002;53:249-251.
25. Tomoaki H, Yamamoto A, Shimabayashi S. Drug release from w/o/w emulsions prepared with different chitosan salts and concomitant creaming up. J Control Release 2000;69:413-419.
26. Bittar N. Usefulness of nifedipine for myocardial ischemia and the nifedipine gastrointestinal therapeutic system. Am J Cardiol 1989;64:31-34.
27. Raemsch KD, Somer J. Pharmacokinetics and metabolism of nifedipine. Hypertension 1983;5:1118-1124.
28. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics, 4th ed. New York: McGraw-Hill; 1999. Chapter 5.
29. Alexandridis P, Hatton TA. Poly(ethylene oxide)-poly(propyleneoxide)- poly(ethylene oxide)block copolymer surfactants in aqueous solutions and at interfaces: Thermodynamics, structure, dynamics, and modeling. Colloid Surf A Physicochem Eng Asp 1995;96:1-46.
30. Chandy T, Sharma CP. Chitosan beads and granules for oral sustained delivery of nifedipine: In vitro studies. Biomaterials 1992;13:949-952.
31. Ho H, Chen CN, Sheu MT. Influence of Pluronic F68 on dissolution and bioavailability characteristics of multiple-layer pellets of nifedipine for controlled release delivery. J Control Release 2000;68:433-440.
32. Pasparakis G, Bouropoulos N. Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate-chitosan beads. Int J Pharm 2006;323:34-42.
33. Macleod GS, Collen JH, Fell JT. The potential use of mixed films of pectin, chitosan and HPMC for bimodal drug release. J Control Release 1999;58:303-310.
34. Li P, Zhang JP, Wang AQ. A Novel N-Succinyl chitosan-graft- polyacrylamide/attapulgite composite hydrogel prepared through inverse suspension polymerization. Macromol Mater Eng 2007;292:962-969.
35. Sankalia MG, Mashru RC, Sankalia JM, Sutariya VB. Reversed chitosan-alginate polyelectrolyte complex for stability improvement of alpha-amylase: Optimization and physicochemical characterization. Eur J Pharm Biopharm 2007;65:215-232.
36. Chen SC, Wu YC, Mi FL, Lin YH, Yu LC, Sung HW. A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery. J Control Release 2004;96:285-300.
37. Lin WC, Yu DG, Yang MC. pH-sensitive polyelectrolyte complex gel microspheres composed of chitosan/sodium tripolyphosphate/dextran sulfate: Swelling kinetics and drug delivery properties. Colloids Surf B Biointerfaces 2005;44:143-151.
38. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv 1985;60:110-111.
39. Ritger PL, Peppas NA. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices. J Control Release 1987;5:37-42.
40. Siepmann J, Peppas NA. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev 2001;48:139-157.
41. Takka S, Ocak OH, Acartürk F. Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies. Eur J Pharm Biopharm 1998;6:241-246.
42. Polk A, Amsden B, Yao KD, Peng T, Goosen MFA. Controlled release of albumin from chitosan-alginate microcapsules. J Pharm Sci 1994;83:178-185.
43. Shu XZ, Zhu KJ. The release behavior of brilliant blue from calcium-alginate gel beads coated by chitosan: The preparation method effect. Eur J Pharm Biopharm 2002;53:193-201.
44. Skjåk-Bræ G, Grasdalen KH, Draget KI, SmidsrØd O. Inhomogeneous polysaccharide ionic gels. Carbohydr Polym 1989;10:31-54.
45. Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev 2002;43:3-12.
46. 2+ ions. React Funct Polym 2004;59:129-140.