The role of cysteine 116 in the active site of the antitumor enzyme L-methionine γ-lyase from Pseudomonas putida

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 7, 2008, Pages 1722-1730

  Kudou, Daizou ^a   Misaki, Shintaro ^b   Yamashita, Masao ^a   Tamura, Takashi ^a   Esaki, Nobuyoshi ^c   Inagaki, Kenji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

L methionine lyase; Pyridoxal 5 phosphate; Saturation mutagenesis

Indexed keywords

ACTIVE SITES; ANTI TUMORS; CATALYTIC ACTIVITIES; CATALYTIC FUNCTIONS; KINETIC (POLYM.); L-METHIONINE; PSEUDOMONAS PUTIDA; SATURATION MUTAGENESIS; WILD-TYPE (WT);

FOOD ADDITIVES;

ANTINEOPLASTIC AGENT; CYSTEINE; L-METHIONINE GAMMA-LYASE; LYASE; METHIONINE; METHIONINE GAMMA LYASE;

ARTICLE; BINDING SITE; CATALYSIS; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; PSEUDOMONAS PUTIDA; SITE DIRECTED MUTAGENESIS;

ANTINEOPLASTIC AGENTS; BINDING SITES; CARBON-SULFUR LYASES; CATALYSIS; CYSTEINE; METHIONINE; MUTAGENESIS, SITE-DIRECTED; PSEUDOMONAS PUTIDA; SUBSTRATE SPECIFICITY;

PSEUDOMONAS PUTIDA;

EID: 47949084023     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80015     Document Type: Article

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