L-methionine-γ-lyase, as a target to inhibit malodorous bacterial growth by trifluoromethionine

Biochemical and Biophysical Research Communications

Volumn 292, Issue 4, 2002, Pages 964-968

  Yoshimura, Mamiko ^a   Nakano, Yoshio ^a   Koga, Toshihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

L methionine deamino mercaptomethane lyase; Methyl mercaptan; Oral malodor; Trifluoromethionine

Indexed keywords

METHANETHIOL; METHIONINE DERIVATIVE; METHIONINE GAMMA LYASE; TRIFLUOROMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GROWTH INHIBITION; HALITOSIS; MOUSE; NONHUMAN; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; SURVIVAL RATE;

BACTERIA (MICROORGANISMS); PORPHYROMONAS; PORPHYROMONAS GINGIVALIS;

EID: 0036293064     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6747     Document Type: Article

References (12)

1. Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
2. Isolation and purification of L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes
3. Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis
4. Mammalian sulfur amino acid metabolism: An overview
5. L-methionine gamma-lyase from Pseudomonas putida and Aeromonas
6. The formation of hydrogen sulfide and methyl mercaptan by oral bacteria
7. Incorporation of trifluoromethionine into a phage lysozyme: Implications and a new marker for use in protein 19F NMR
8. Heterogeneity of virulence among strains of Bacteroides gingivalis
9. Structural analysis of the L-methionine gamma-lyase gene from Pseudomonas putida
10. The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5′-phosphate-dependent enzymes
11. DL-S-Trifluoromethylhomocysteine, a novel inhibitor of microbial growth
12. Trifluoromethionine, a prodrug designed against methionine gamma-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis