Crystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor

Journal of Molecular Biology

Volumn 311, Issue 4, 2001, Pages 789-801

  Steegborn, Clemens ^a   Laber, Bernd ^b   Messerschmidt, Albrecht ^a   Huber, Robert ^a   Clausen, Tim ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b BAYER CROPSCIENCE AG   (Germany)

Author keywords

Crystal structures; Cystathionine synthase; Drug development; Inhibitor complexes; Pyridoxal 5' phosphate

Indexed keywords

CYSTATHIONE SYNTHETASE; CYSTATHIONINE GAMMA SYNTHETASE INHIBITOR; ENZYME INHIBITOR; PYRIDOXAL 5 PHOSPHATE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOSYNTHESIS; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; NONHUMAN; PLANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS;

NICOTIANA TABACUM; TABACUM;

EID: 0035943386     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4880     Document Type: Article

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