Prosegment of tripeptidyl peptidase I is a potent, slow-binding inhibitor of its cognate enzyme

Journal of Biological Chemistry

Volumn 283, Issue 24, 2008, Pages 16497-16504

  Golabek, Adam A ^a,b   Dolzhanskaya, Natalia ^a   Walus, Marius ^a   Wisniewski, Krystyna E ^a   Kida, Elizabeth ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ENZYMES; ESCHERICHIA COLI; MAMMALS; ORGANIC ACIDS; PH EFFECTS;

AMINO ACID RESIDUES; BINDING INHIBITORS; CEROID LIPOFUSCINOSIS; COGNATE PROTEASES; INHIBITION CONSTANTS; N TERMINUSES; NANOMOLAR RANGES; NEURODEGENERATIVE DISORDERS; PROTECTIVE EFFECTS;

ENZYME INHIBITION;

CEROID; PEPTIDASE; TRIPEPTIDYL PEPTIDASE I; UNCLASSIFIED DRUG; CARBOXYPEPTIDASE; PROTEINASE; PROTEINASE INHIBITOR; SEDOLISIN; TRIPEPTIDYL-PEPTIDASE I;

ARTICLE; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; ESCHERICHIA COLI; GENE MUTATION; LIPOFUSCINOSIS; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN PURIFICATION; BIOCHEMISTRY; CHEMISTRY; DOSE RESPONSE; GENE EXPRESSION REGULATION; HUMAN; KINETICS; METABOLISM; METHODOLOGY; MUTATION; NEURONAL CEROID LIPOFUSCINOSIS; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN TERTIARY STRUCTURE; TIME;

ESCHERICHIA COLI; MAMMALIA;

BIOCHEMISTRY; CARBOXYPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MUTATION; NEURONAL CEROID-LIPOFUSCINOSES; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS;

EID: 47749146940     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800458200     Document Type: Article

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