Production and characterization of recombinant human CLN2 protein for enzyme-replacement therapy in late infantile neuronal ceroid lipofuscinosis

Biochemical Journal

Volumn 357, Issue 1, 2001, Pages 49-55

  Lin, L ^a   Lobel, P ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Endocytosis; Lysosomal storage; Overexpression; Tripeptidyl peptidase I

Indexed keywords

ENZYMES; GENETIC ENGINEERING; MONOMERS; MUTAGENESIS;

GEL FILTRATION;

BIOCHEMISTRY;

ENZYME PRECURSOR; GENE PRODUCT; MANNOSE 6 PHOSPHATE; MITOCHONDRIAL ENZYME; PEPTIDASE; PROTEIN CLN2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RECOMBINANT PROTEIN; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CEREBELLUM; CHO CELL; ENDOCYTOSIS; ENZYME REPLACEMENT; ENZYME SUBUNIT; FIBROBLAST; GEL FILTRATION; GENE MUTATION; GENETIC ENGINEERING; GRANULE CELL; HUMAN; HUMAN CELL; INFANT DISEASE; LIPOFUSCINOSIS; LYSOSOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECRETION; RAT; RECESSIVE INHERITANCE;

ANIMALS; ARGININE; BIOLOGICAL TRANSPORT; CELL LINE; CHO CELLS; CODON, TERMINATOR; CRICETINAE; ENDOCYTOSIS; ENDOPEPTIDASES; FIBROBLASTS; HETEROZYGOTE; HUMANS; INFANT; KINETICS; MOLECULAR SEQUENCE DATA; NEURONAL CEROID-LIPOFUSCINOSES; PEPTIDE HYDROLASES; RECEPTOR, IGF TYPE 2; RECOMBINANT PROTEINS; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0035397487     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570049     Document Type: Article

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