Heterozygosity of genes on the sex chromosome regulates Candida albicans virulence

Molecular Microbiology

Volumn 64, Issue 6, 2007, Pages 1587-1604

  Wu, Wei ^a   Lockhart, Shawn R ^a   Pujol, Claude ^a   Srikantha, Thyagarajan ^a   Soll, David R ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CHROMOSOME 5; CHROMOSOME DELETION; CHROMOSOME DUPLICATION; CHROMOSOME LOSS; CONTROLLED STUDY; FEMALE; FUNGAL VIRULENCE; GENE LOCUS; GENETIC REGULATION; HETEROZYGOSITY LOSS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX CHROMOSOME;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CHROMOSOME MAPPING; CHROMOSOMES, FUNGAL; DISEASE MODELS, ANIMAL; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENES, MATING TYPE, FUNGAL; HETEROZYGOTE; MICE; POLYMORPHISM, GENETIC; VIRULENCE;

CANDIDA ALBICANS;

EID: 34249995958     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2007.05759.x     Document Type: Article

References (48)

1. Anderson, J.M. Soll, D.R. (1987) Unique phenotype of opaque cells in the white-opaque transition of Candida albicans. J Bacteriol 169 : 5579 5588.
2. Aramayo, R. Metzenberg, R.L. (1996) Meiotic transvection in fungi. Cell 86 : 103 113.
3. Bedell, G. Soll, D.R. (1979) The effects of low concentrations of zinc on the growth and dimorphism of Candida albicans: evidence for zinc resistant and zinc sensitive pathways for mycelium formation. Infect Immun 26 : 348 354.
4. Bennett, R.J. Johnson, A.D. (2003) Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains. EMBO J 22 : 2505 2515.
5. Blignaut, E., Pujol, C., Lockhart, S., Joly, S. Soll, D.R. (2002) Ca3 fingerprinting of Candida albicans isolates from human immunodeficiency virus-positive individuals reveals a new clade in South Africa. J Clin Microbiol 40 : 826 836.
6. Chandler, V.L., Eggleston, W.B. Dorweiler, J.E. (2000) Paramutation in maize. Plant Mol Biol 43 : 121 145.
7. Chibana, H., Iwaguchi, S., Homma, M., Chindamporn, A., Nakagawa, Y. Tanaka, K. (1994) Diversity of tandemly repetitive sequences due to short periodic repetitions in the chromosomes of Candida albicans. J Bacteriol 176 : 3851 3858.
8. Coste, A., Turner, V., Ischer, F., Morschhauser, J., Forche, A., Semelcki, A., et al. (2006) A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. Genetics 172 : 2139 2156.
9. Forche, A., Magee, P.T., Magee, B.B. May, G. (2004) Genome-wide single-nucleotide polymorphism map for Candida albicans. Eukaryot Cell 3 : 705 714.
10. Gibson, J.B., Reed, D.S., Bartoszewski, S. Wilks, A.V. (1999) Structural changes in the promoter region mediate transvection at the sn-glycerol-3- phosphate dehydrogenase gene of Drosophila melanogaster. Biochem Genet 37 : 301 315.
11. Grant, D., Unadkat, S., Katzen, A., Krishnan, K.S. Ramaswami, M. (1998) Probable mechanisms underlying interallelic complementation and temperature-sensitivity of mutations at the shibire locus of Drosophila melanogaster. Genetics 149 : 1019 1030.
12. Haber, J. (1998) Mating-type gene switching in Saccharomyces cerevisiae. Annu Rev Genet 32 : 561 599.
13. Haber, J.E. (1992) Mating-type gene switching in Saccharomyces cerevisiae. Trends Genet 8 : 446 452.
14. Haber, J.E., Rogers, D.T. McCusker, J. (1980) Homothallic conversions of yeast mating type genes occur by intrachromosomal recombination. Cell 22 : 277 289.
15. Herskowitz, I. Oshima, Y. (1981) Control of cell type in Saccharomyces cerevisiae: mating type and mating-type interconversion. In The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance Strathern, J.N., Jones E.W. Broach, J.R. (eds). New York : Cold Spring Harbor Laboratory, pp. 181 210.
16. Hsueh, Y.-P., Idnurm, A. Heitman, J. (2006) Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome. PLoS Genetics 2 : e184.
17. Hull, C.M. Johnson, A.D. (1999) Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science 285 : 1271 1275.
18. Hull, C.M., Raisner, R.M. Johnson, A.D. (2000) Evidence for mating of the 'asexual' yeast Candida albicans in a mammalian host. Science 289 : 307 310.
19. Ibrahim, A.S., Magee, B.B., Sheppard, D.C., Yang, M., Kauffman, S., Becker, J., et al. (2005) Effects of ploidy and mating type on virulence of Candida albicans. Infect Immun 73 : 7366 7374.
20. Iwaguchi, S.I., Homma, M., Chibana, H. Tanaka, K. (1992) Isolation and characterization of a repeated sequence (RPS1) of Candida albicans. J Gen Microbiol 138 : 1893 1900.
21. Janbon, G., Sherman, F. Rustchenko, E. (1998) Monosomy of a specific chromosome determines 1-sorbose utilization: a novel regulatory mechanism in Candida albicans. Proc Natl Acad Sci USA 95 : 5150 5155.
22. Joly, S., Pujol, C., Rysz, M., Vargas, K. Soll, D.R. (1999) Development and characterization of complex DNA fingerprinting probes for the infectious yeast Candida dubliniensis. J Clin Microbiol 37 : 1035 1044.
23. Klar, A.J.S., Fogel, S. Radin, D.M. (1979) Switching of a mating-type a mutant allele in budding yeast Saccharomyces cerevisiae. Genetics 92 : 759 776.
24. Legrand, M., Lephart, P., Forche, A., Mueller, F.-M.C., Walsh, T., Magee, P.T. Magee, B.B. (2004) Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formation. Mol Micro 52 : 1451 1462.
25. Lockhart, S.R., Reed, B., Pierson, C.L. Soll, D.R. (1996) Most frequent scenario for recurrent Candida vaginitis is strain maintenance with 'substrain shuffling': demonstration by sequential DNA fingerprinting with probes Ca3, C1, and CARE2. J Clin Microbiol 34 : 767 777.
26. Lockhart, S.R., Pujol, C., Daniels, K., Miller, M., Johnson, A. Soll, D.R. (2002) In Candida albicans, white-opaque switchers are homozygous for mating type. Genetics 162 : 737 745.
27. Lockhart, S.R., Daniels, K.J., Zhao, R., Wessels, D. Soll, D.R. (2003) Cell biology of mating in Candida albicans. Eukaryot Cell 2 : 49 61.
28. Lockhart, S.R., Wu, W., Radke, J.B. Soll, D.R. (2005) Increased virulence and competitive advantage of a/α over a/a or α/α offspring conserves the mating system of Candida albicans. Genetics 169 : 1883 1890.
29. Magee, B.B. Magee, P.T. (2000) Induction of mating in Candida albicans by construction of MTLa and MTLalpha strains. Science 289 : 310 313.
30. Miller, M.G. Johnson, A.D. (2002) White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating. Cell 110 : 293 302.
31. Mongelard, F., Labrador, M., Baxter, E.M., Gerasimova, T.I. Corces, V.G. (2002) Trans-splicing as a novel mechanism to explain interallelic complementation in Drosophila. Genetics 160 : 1481 1487.
32. Oh, S.-H., Cheng, G., Nuessen, J., Jajko, R., Yeater, K., Zhao, X., et al. (2005) Clade specificity of Candida albicans ALS3 alleles and functional specificity of Als3p proteins discriminated by the number of copies of the tandem repeat sequence in the central domain. Microbiology 151 : 673 681.
33. Pfaller, M.A., Messer, S.A., Hollis, R.J., Jones, R.N., Doern, G.V., Brandt, M.E. Hajjeh, R.A. (1999) Trends in species distribution and susceptibility to fluconazole among blood stream isolates of Candida species in the United States. Diagn Microbiol Infect Dis 33 : 217 222.
34. Pfaller, M.A., Diekema, D.J., International Fungal Surveillance Participant Group. (2004) Twelve years of fluconazole in clinical practice: global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida. Clin Microbiol Infect 10 : 11 23.
35. Pujol, C., Joly, S., Nolan, B., Srikantha, T. Soll, D.R. (1999) Microevolutionary changes in Candida albicans identified by the complex Ca3 fingerprinting probe involve insertions and deletions of the full-length repetitive sequence RPS at specific genomic sites. Microbiology 145 : 2635 2646.
36. Pujol, C., Pfaller, M. Soll, D.R. (2002) Ca3 fingerprinting of Candida albicans bloodstream isolates from the United States, Canada, South America, and Europe reveals a European clade. J Clin Microbiol 40 : 2729 2740.
37. Pujol, C., Messer, S.A., Pfaller, M. Soll, D.R. (2003) Drug resistance is not directly affected by mating type locus zygosity in Candida albicans. Antimicrob Agents Chemother 47 : 1207 1212.
38. Pujol, C., Dodgson, A. Soll, D.R. (2005) Population genetics of ascomycetes pathogenic to humans and animals. In Evolutionary Genetics of Fungi. Xu, J.-P. (ed.). Norfolk, UK : Horizon Scientific Press, pp. 149 188.
39. Reuss, O., Vik, A., Kolter, R. Morschhauser, J. (2004) The SAT1 flipper, an optimized tool for gene disruption in Candida albicans. Gene 341 : 119 127.
40. Rustad, T.R., Stevens, D.A., Pfaller, M.A. White, T.C. (2002) Homozygosity at the Candida albicans MTL locus associated with azole resistance. Microbiology 148 : 1061 1072.
41. Sanyal, K., Baum, M. Carbon, J. (2004) Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique. Proc Natl Acad Sci USA 101 : 11374 11379.
42. Selmecki, A., Forche, A. Berman, J. (2006) Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313 : 367 370.
43. Soll, D.R. Pujol, C. (2003) DNA fingerprinting Candida albicans clades. FEMS Immunol Med Microbiol 39 : 1 7.
44. Staib, P., Kretschmar, M., Nichterlein, T., Hof, H. Morschhauser, J. (2002) Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene. Mol Microbiol 44 : 1351 1366.
45. Steingrimsson, E., Arnheiter, H., Hallsson, J.H., Lamoreux, M.L., Copeland, N.G. Jenkins, N.A. (2003) Interallelic complementation at the mouse Mitf locus. Genetics 163 : 267 276.
46. Tavanti, A., Davidson, A.D., Fordyce, M.J., Gow, N.A.R., Maiden, M.C.J. Odds, F.C. (2005) Population structure and properties of Candida albicans as determined by multilocus sequence typing. J Clin Microbiol 43 : 5601 5613.
47. Wu, W., Pujol, C., Lockhart, S.R. Soll, D.R. (2005) Mechanisms of mating type homozygosis in C. albicans. Genetics 169 : 1311 1327.
48. Zhao, X., Pujol, C., Soll, D.R. Hoyer, L.L. (2003) Allelic variation in the contiguous loci encoding Candida albicans ALS5, ALS1 and ALS9. Microbiology 149 : 2947 2960.