Placental transport of folate and thiamine: A mini-review

Current Women's Health Reviews

Volumn 4, Issue 2, 2008, Pages 141-146

  Keating, Elise ^a   Martel, Fátima ^a  

^a University of Porto   (Portugal)

Author keywords

5 methyltetrahydrofolate; Methotrexate; Multidrug resistance protein family; Reduced folate carrier; THIAM pyrophosphate

Indexed keywords

FOLATE RECEPTOR; FOLIC ACID; THIAMINE;

DRUG STRUCTURE; DRUG UPTAKE; FETAL WELL BEING; FETOPLACENTAL UNIT; FETUS DEVELOPMENT; FETUS GROWTH; FOLIC ACID DEFICIENCY; HUMAN; LOW BIRTH WEIGHT; MATERNAL TREATMENT; NUTRITIONAL STATUS; PLACENTAL TRANSFER; PRIORITY JOURNAL; SHORT SURVEY; THIAMINE DEFICIENCY; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION;

EID: 47749125843     PISSN: 15734048     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340408784246377     Document Type: Short Survey

References (59)

1. Herbert V. Folic acid, in Modern Nutrition in Health and Disease, Shilo ME, Olson JA, Shihe M, Ross AH, eds,. et al., Editors. 1999, Lippincott, Williams & Wilkins: London.
2. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab 2000; 71: 121-38.
3. Worthington-Roberts B. Nutrition, in Cherry and Merkatz's Complications of Pregnancy, Cohen WR, Sheldon CH, Merkatz IR, eds, 1999, Lippincott Williams & Wilkins: London.
4. Pitkin RM. Folate and neural tube defects. Am J Clin Nutr 2007; 85: 285S-288S.
5. Assaraf YG. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updat 2006; 9: 227-46.
6. Picciano MF. Pregnancy and lactation: physiological adjustments, nutritional requirements and the role of dietary supplements. J Nutr 2003; 1331997S-2002S.
7. de Boo HA, Harding JE. The developmental origins of adult disease (Barker) hypothesis. Aust N Z J Obstet Gynaecol 2006; 46(1): 4-14.
8. Yajnik CS. Early life origins of insulin resistance and type 2 diabetes in India and other Asian countries. J Nutr 2004; 134(1): 205-10.
9. Rao S, Yajnik CS, Kanade A, et al. Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pane Maternal Nutrition Study. J Nutr 2001; 131(4):1217-24.
10. Wald N, Sneddon J. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991; 338(8760): 131-7.
11. Prasad PD, Ramamoorthy S, Leibach FH, Ganapathy V. Molecular cloning of the human placental folate transporter. Biochem Biophys Res Commun 1995; 206(2): 681-7.
12. Whetstine JR, Flatley RM, Matherly LH. The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. Biochem J 2002; 367(Pt 3): 629-40.
13. Ganapathy V, Smith SB, Prasad PD. SLC19: the folate/thiamine transporter family. Pflugers Arch 2004; 447(5): 641-6.
14. Green T, Ford HC. Human placental microvilli contain high-affinity binding sites for folate. Biochem J 1984; 21875-80.
15. Kamen BA, Smith AK. A review of folate receptor alpha cycling and 5-mediyltetrahydrofolate accumulation with an emphasis on cell models in vitro. Adv Drug Deliv Rev 2004; 561085-1097.
16. Antony AC, Utley C, KC Van Horne, Kolhouse JF. Isolation and characterization of a folate receptor from human placenta. J Biol Chem 1981; 256(18): 9684-92.
17. Matherly LH, Goldman DI. Membrane transport of folates. Vitam Horm, 2003; 66403-56.
18. Sabharanjak S, Mayor S. Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev 2004; 56:1099-1109.
19. Elnakat H, Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 2004; 56(8): 1067-84.
20. Prasad PD, Ramamoorthy S, Moe AJ, et al. Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta 1994; 1223(1): 71-5.
21. Ratnam M, Marquardt H, Duhring JL, Freisheim JH. Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. Biochemistry 1989; 28(20): 8249-54.
22. Antony AC. Folate receptors. Annu Rev Nutr 1996; 16501-21.
23. Sirotnak FM, Tolner B. Carrier-mediated membrane transport of folates. Annu Rev Nutr 1999; 1991-122.
24. Verma RS, Gullapalli S, Antony AC. Evidence that the hydrophobicity of isolated, in situ, and de novo-synthesized native human placental folate receptors is a function of glycosyl-phosphatidylinositol anchoring to membranes. J Biol Chem 1992; 267(6): 4119-27.
25. Antony AC. In utero physiology: role of folic acid in nutrient delivery and fetal development Am J Clin Nutr 2007; 85(2): 598S-603S.
26. Ganapathy V, Prasad PD, Ganapathy ME, Leibach FH. Placental transporters relevant to drug distribution across the maternal-fetal interface. J Pharmacol Exp Ther 2000; 294(2): 413-20.
27. Bisseling TM, Steegers EAP, vanden Hauvel JJM, et al. Placental folate transport and binding are not impaired in pregnancies complicated by fetal growth restriction. Placenta 2004; 25588-593.
28. Chancy CD, Kekuda R, Huang W, et al. Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J Biol Chem 2000; 275(27): 20676-84.
29. Liu F, Snares MJ, Audus KL. Permeability properties of monolayers of the human trophoblast cell line BeWo. Am J Physiol 1997; 273(5 Pt 1): C1596-604.
30. Sastry BV. Techniques to study human placental transport. Adv Drug Deliv Rev 1999; 38(1): 17-39.
31. Takahashi T, Utoguchi N, Takara A, et al. Carrier-mediated transport of folic acid in BeWo cell monolayers as a model of the human trophoblast. Placenta 2001; 22863-869.
32. Keating E, Lemos C, Azevedo I, Martel F. Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. Can J Physiol Pharmacol 2006; 84(2): 247-55.
33. Keating E, Goncalves P, Costa F, et al. Placental folic acid uptake: interference by pharmacotherapy, drugs of abuse and pathological conditions. Submitted paper
34. Qiu A, Jansen M, Sakaris A, et al. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006; 127(5): 917-28.
35. Prasad PD, Mahesh VB, Leibach LFH, Ganapathy V. Functional couploing between bafilomycin A1-sensitive proton purn and probenecid-sensitive folate transporter in human placental choriocarcinoma cells. Biochim Biophys Acta 1994; 1222309-314.
36. Young AM, Allen CE, Audus KL. Efflux transporters of the human placenta. Adv Drug Deliv Rev 2003; 55(1): 125-32.
37. Keating E, Goncalves P, Lemos C, et al. Progesterone inhibits folic acid transport in human trophoblasts. J Membr Biol 2007; 216(2-3): 143-52.
38. Keating E, Lemos C, Goncalves P, Martel F. Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo. J Nutr Biochem 2008; 19(2): 91-100.
39. Gregory JF, 3rd. Bioavailability of thiamin. Eur J Clin Nutr 1997; 51 (Suppl 1)S34-7.
40. Rindi G, Laforenza U. Thiamine intestinal transport and related issues: recent aspects. Proc Soc Exp Biol Med 2000; 224(4): 246-55.
41. Tanphaichitr V. Thiarnin, in Modern Nutrition in Health and disease, Shils ME, Oslson JA, Shike M, et al., ed,. 1999, Lippincott, Williams & Wilkins: London, LTK. 381-389.
42. Singleton CK, Martin PR. Molecular mechanisms of thiamine utilization. Curr Mol Med 2001; 1(2): 197-207.
43. Levin SW, Roecklein BA, Mukherjee AB. Intrauterine growth retardation caused by dietary biotin and thiamine deficiency in the rat Res Exp Med (Berl) 1985; 185(5): 375-81.
44. Dutta B, Huang W, Molero M, et al. Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem 1999; 274(45): 31925-9.
45. Diaz GA, Banikazemi M, Oishi K, Desnick RJ, Gelb BD. Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaernia syndrome. Nat Genet 1999; 22(3): 309-12.
46. Fleming JC, Tartaglini E, Steinkamp MP, et al. The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter. Nat Genet 1999; 22(3): 305-8.
47. Labay V, Raz T, D Baron D, et al. Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Nat Genet 1999; 22(3): 300-4.
48. Eudy JD, Spiegelstein O, Barber RC, et al. Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab 2000; 71(4): 581-90.
49. Koepsell H, Schmitt BM, Gorboulev V. Organic cation transporters. Rev Physiol Biochem Pharmacol 2003; 15036-90.
50. Dancis J, Wilson D, Hoskins IA, Levitz M. Placental transfer of thiamine in the human subject: in vitro perfusion studies and maternal-cord plasma concentrations. Am J Obstet Gynecol 1988; 159(6): 1435-9.
51. Grassl SM. Thiamine transport in human placental brush border membrane vesicles. Biochim Biophys Acta 1998; 1371(2): 213-22.
52. Keating E, Lemos C, Azevedo I, Martel F. Characteristics of thiamine uptake by the BeWo human trophoblast cell line. J Biochem Mol Biol 2006; 39(4): 383-93.
53. Shiverick KT, King A, Frank H, et al. Cell culture models of human trophoblast II: trophoblast cell lines - a workshop report Placenta 2001; 22 (Suppl A)S104-6.
54. Bloxam DL, Bax CM, Bax BE. Culture of syncytiotrophoblast for the study of human placental transfer. Part I: Isolation and purification of cytotrophoblast. Placenta 1997; 18(2-3): 93-8.
55. Moreau R, Simoneau L, Lafond J. Characteristics of calcium uptake by BeWo cells, a human trophoblast cell line. Placenta 2001; 22(8-9): 768-75.
56. Starreveld JS, van Denderen J, Verrijt CE, Kroos MJ, van Dijk JP. Morphological differentiation of cytotrophoblasts cultured in Medium 199 and in keratinocyte growth medium. Eur J Obstet Gynecol Reprod Biol 1998; 79(2): 205-10.
57. Bax CM, Ryder TA, Mobberley MA, et al. Ultrastructural changes and immunocytochemical analysis of human placental trophoblast during short-term culture. Placenta 1989; 10(2): 179-94.
58. Bischof P, Irminger-Finger I. The human cytotrophoblastic cell, a mononuclear chameleon. Int J Biochem Cell Biol 2005; 37(1): 1-16.
59. Keating E, Goncalves P, Costa F, et al. Placental folic acid uptake: interference by pharmacotherapy, drugs of abuse and pathological conditions. Submitted paper.