Non-native interhelical hydrogen bonds in the cystic fibrosis transmembrane conductance regulator domain modulated by polar mutations

Biochemistry

Volumn 43, Issue 25, 2004, Pages 8077-8083

  Choi, Mei Y ^c   Cardarelli, Lia ^c   Therien, Alex G ^b   Deber, Charles M ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BOND STRENGTH (CHEMICAL); HYDROGEN BONDS; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; PRESSURE EFFECTS; PROTEINS;

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS (CFTR); POLAR MUTATION; PROTEIN DYNAMICS; TRANSMEMBRANES;

BIOCHEMISTRY;

ALANINE; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; MUTANT PROTEIN; PHENYLALANINE; PROLINE; SERINE; THREONINE; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRYPTOPHAN; TYROSINE; VALINE;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; DYNAMICS; HYDROGEN BOND; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; ROTATION; SEQUENCE ANALYSIS; SPONTANEOUS MUTATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS; CIRCULAR DICHROISM; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 3042517378     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0494525     Document Type: Article

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