Antifungal activity of flocculosin, a novel glycolipid isolated from Pseudozyma flocculosa

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 4, 2005, Pages 1597-1599

  Mimee, Benjamin ^a   Labbé, Caroline ^a   Pelletier, René ^b   Bélanger, Richard R ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; FLOCCULOSIN; FLUCONAZOLE; GLYCOLIPID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIFUNGAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA LUSITANIAE; CANDIDA PARAPSILOSIS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CYTOPATHOGENIC EFFECT; DRUG EFFECT; DRUG EFFICACY; DRUG ISOLATION; DRUG POTENTIATION; ERYTHROCYTE; FUNGUS; FUNGUS CULTURE; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PH; PRIORITY JOURNAL; PSEUDOZYMA FLOCCULOSA; SACCHAROMYCES CEREVISIAE; SHEEP; TEMPERATURE DEPENDENCE; TRICHOSPORON ASAHII; YEAST;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; CELLOBIOSE; DRUG SYNERGISM; FUNGI; GLYCOLIPIDS; HUMANS; MICROBIAL SENSITIVITY TESTS; MYCOSES; USTILAGINALES;

EID: 16244384473     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.4.1597-1599.2005     Document Type: Article

References (13)

1. Boucher, H. W., A. H. Groll, C. C. Chiou, and T. J. Walsh. 2004. Newer systemic antifungal agents. Drugs 64:1997-2020.
2. Cheng, Y., D. J. McNally, C. Labbé, N. Voyer, F. Belzile, and R. R. Bélanger. 2003. Insertional mutagenesis of a fungal biocontrol agent led to discovery of a rare cellobiose lipid with antifungal activity. Appl. Environ. Microbiol. 69:2595-2602.
3. De Pauw, B. E. 2000. New antifungal agents and preparation. Int. J. Antimicrob. Agents 16:147-150.
4. Deray, G. 2002. Amphotericin B nephrotoxicity. J. Antimicrob. Chemother. 49(Suppl. 1):37-41.
5. Georgopapadakou, N. K., and T. J. Walsh. 1996. Antifungal agents: chemotherapeutic targets and immunologic strategies. Antimicrob. Agents Chemother. 40:279-291.
6. Hajlaoui, M. R., J. A. Traquair, W. R. Jarvis, and R. R. Bélanger. 1994. Antifungal activity of extracellular metabolites produced by Sporothrix flocculosa. Biocontrol Sci. Technol. 4:229-237.
7. Masia Canuto, M., and F. Gutierrez Rodero. 2002. Antifungal drug resistance to azoles and polyenes. Lancet Infect. Dis. 2:550-563.
8. NCCLS. 2002. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard, 2nd ed. NCCLS document M27-A2. NCCLS, Wayne, Pa.
9. Sheehan, D. J., C. A. Hitchcock, and C. M. Sibley. 1999. Current and emerging azole antifungal agents. Clin. Microbiol. Rev. 12:40-79.
10. Skehan, P., R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J. T. Warren, H. Bokesch, S. Kenney, and M. R. Boyd. 1990. New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 82:1107-1112.
11. Sorensen, K. N., K.-H. Kim, and J. Y. Takemoto. 1996. In vitro antifungal and fungicidal activities and erythrocyte toxicities of cyclic lipodepsinon-apeptides produced by Pseudomonas syringae pv. syringae. Antimicrob. Agents Chemother. 40:2710-2713.
12. Yawata, Y. 2003. Cell membrane: the red blood cell as a model, p. 251-260. Wiley-VCH Verlag GmbH, Weinheim, Germany.
13. Zarif, L., J. R. Graybill, D. Perlin, L. Najvar, R. Bocanegra, and R. J. Mannino. 2000. Antifungal activity of amphotericin B cochleates against Candida albicans infection in a mouse model. Antimicrob. Agents Chemother. 44:1463-1469.