Rational design, solution conformation and identification of functional residues of the soluble and structured Nogo-54, which mimics Nogo-66 in inhibiting the CNS neurite outgrowth

Biochemical and Biophysical Research Communications

Volumn 373, Issue 4, 2008, Pages 498-503

  Li, Minfen ^a   Li, Yali ^b   Liao, Xuanhao ^a   Liu, Jingxian ^c   Qin, Haina ^a   Xiao, Zhi cheng ^b,d   Song, Jianxing ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Antagonist design; Circular dichroism; CNS injury; Neurite outgrowth; NMR spectroscopy; Nogo; Nogo 66 receptor; Solution conformation

Indexed keywords

MUTANT PROTEIN; PROTEIN NOGO; PROTEIN NOGO 54; PROTEIN NOGO 54M; PROTEIN NOGO 66;

ARTICLE; CENTRAL NERVOUS SYSTEM; CIRCULAR DICHROISM; DRUG DESIGN; NERVE FIBER GROWTH; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CENTRAL NERVOUS SYSTEM; CIRCULAR DICHROISM; DRUG DESIGN; HUMANS; MUTATION; MYELIN PROTEINS; NEURITES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; RECEPTORS, CELL SURFACE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 47649133240     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.06.052     Document Type: Article

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