A novel nucleolar transcriptional activator ApLLP for long-term memory formation is intrinsically unstructured but functionally active

Biochemical and Biophysical Research Communications

Volumn 366, Issue 2, 2008, Pages 585-591

  Liu, Jingxian ^a   Song, Jianxing ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

ApLLP; Aplysia; Circular dichroism; DNA binding; Intrinsically unstructured protein (IUP); Long term memory; Neuron; NMR spectroscopy; Nucleolar transcriptional activator; Short term memory

Indexed keywords

APLLP PROTEIN; CYCLIC AMP; DNA; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

APLYSIA; ARTICLE; CYCLIC AMP RESPONSIVE ELEMENT; DNA BINDING; LONG TERM MEMORY; MOLECULAR MECHANICS; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; MEMORY; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS;

APLYSIA;

EID: 37449005942     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.022     Document Type: Article

References (26)

1. Martin S.J., Grimwood P.D., and Morris R.G.M. SYNAPTIC PLASTICITY AND MEMORY: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23 (2000) 649-711
2. Colombo P.J. Learning-induced activation of transcription factors among multiple memory systems. Neurobiol. Learn. Mem. 82 (2004) 268-277
3. Bailey C.H., and Kandel E.R. Structural changes accompanying memory storage. Annu. Rev. Physiol. 5 (1983) 397-426
4. Glanzman D.L., Kandel E.R., and Schacher S. Target dependent structural changes accompanying long-term synaptic facilitation in Aplysia sensory neurons. Science 249 (1990) 799-802
5. Dash P.K., Hochner B., and Kandel E.R. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 345 (1990) 718-721
6. Bartsch D., Casadio A., Karl K.A., Serodio P., and Kandel E.R. CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95 (1998) 211-223
7. Bourtchouladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., and Silva A.J. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element binding protein. Cell 79 (1994) 59-68
8. Pittenger C., Huang Y.-Y., Paletzki R.F., Bourtchouladze R., Scanlin H., Vronskaya S., and Kandel E.R. Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampusdependent spatial memory. Neuron 34 (2002) 447-462
9. Kim H., Chang D.-J., Lee J.-A., Lee Y.-S., and Kaang B.-K. Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein. Neurosci. Lett. 343 (2003) 134-138
10. Kim H., Lee S.-H., Han J.-H., Lee J.-A., Cheang Y.-H., Chang D.-J., Lee Y.-S., and Kaang B.-K. A Nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in Aplysia neurons. Neuron 49 (2006) 707-718
11. Obradovic Z., Peng K., Vucetic S., Radivojac P., and Dunker A.K. Exploiting heterogeneous sequence properties improves prediction of protein disorder. Proteins 61 (2005) 176-182
12. Wei Z., and Song J. Molecular mechanism underlying the thermal stability and pH-induced unfolding of CHABII. J. Mol. Biol. 348 (2005) 205-218
13. Delaglio F., Grzesiek S., Vuister G.W., Zhu G., Pfeifer J., and Bax A. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6 (1995) 277-293
14. Johnson B., and Blevins R.A. NMRView: a computer program for the visualization and analysis of NMR data. J. Biomol. NMR 4 (1994) 603-614
15. Li M., Liu J., Ran X., Fang M., Shi J., Qin H., Goh J.M., and Song J. Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water. Biophys. J. 91 (2006) 4201-4209
16. Li M., Liu J., and Song J. Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration. Protein Sci. 15 (2006) 1835-1841
17. Li M., and Song J. Nogo-B receptor possesses an intrinsically unstructured ectodomain and a partially folded cytoplasmic domain. Biochem. Biophys. Res. Commun. 360 (2007) 128-134
18. Venyaminov S.Y., and Yang J.T. Determination of protein secondary structure. In: Fasman G.D. (Ed). Circular Dichroism and the Conformational Analysis of Biomolecules (1996), Plenum Press, New York 69-107
19. Eckel-Mahan K.L., and Storm D.R. Rookie snail protein LAPS veteran C/EBP: net transcriptional proceeds for long-term facilitation. Neuron 49 (2006) 645-646
20. Nakaya T., Kawahara S., Watanabe S., Lee D., Suzuki T., and Kirino Y. Identification and expression of a novel gene in odour-taste associative learning in the terrestrial slug. Genes Cells 6 (2001) 43-56
21. Tompa P. Intrinsically unstructured proteins. Trends Biochem. Sci. 27 (2002) 527-533
22. Uversky V.N. Natively unfolded proteins: a point where biology waits for physics. Protein Sci. 11 (2002) 739-756
23. Dyson H.J., and Wright P.E. Intrinsically unstructured proteins and their functions. Nat. Rev. Mol. Cell Biol. 6 (2005) 197-208
24. Ward J.J., Sodhi J.S., McGuffin L.J., Buxton B.F., and Jones D.T. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J. Mol. Biol. 337 (2004) 635-645
25. Gunasekaran K., Tsai C.J., Kumar S., Zanuy D., and Nussinov R. Extended disordered proteins: targeting function with less scaffold. Trends Biochem. Sci. 28 (2003) 81-85
26. Li M., and Song J. The N- and C-termini of the human Nogo molecules are intrinsically unstructured: bioinformatics, CD, NMR characterization and its functional implications. Proteins: Struct. Funct. Bioinform. 68 (2007) 100-108