메뉴 건너뛰기




Volumn 20, Issue 8, 2008, Pages 939-948

Central and peripheral role of the nociceptin/orphaninFQ system on normal and disturbed colonic motor function and faecal pellet output in the rat

Author keywords

Castor oil diarrhoea; Colonic propulsion; Corticotrophin release factor; Faecal pellet output; Nociceptin orphanin FQ analogues; Restraint stress

Indexed keywords

CASTOR OIL; CORTICOTROPIN RELEASING FACTOR; NOCICEPTIN; NOCICEPTIN RECEPTOR AGONIST; NOCICEPTIN RECEPTOR ANTAGONIST;

EID: 47649111176     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2008.01120.x     Document Type: Article
Times cited : (21)

References (51)
  • 1
    • 0029166509 scopus 로고
    • Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
    • Meunier JC, Mollereau C, Toll L, et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 1995 377 : 532 5.
    • (1995) Nature , vol.377 , pp. 532-5
    • Meunier, J.C.1    Mollereau, C.2    Toll, L.3
  • 2
    • 0028284167 scopus 로고
    • Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type
    • Bunzow JR, Saez C, Mortrud M, et al. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. FEBS Lett 1994 347 : 284 8.
    • (1994) FEBS Lett , vol.347 , pp. 284-8
    • Bunzow, J.R.1    Saez, C.2    Mortrud, M.3
  • 3
    • 0034101011 scopus 로고    scopus 로고
    • Pharmacology of nociceptin and its receptor: A novel therapeutic target
    • Calò G, Guerrini R, Rizzi A, Salvadori S, Regoli D. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol 2000 129 : 1261 83.
    • (2000) Br J Pharmacol , vol.129 , pp. 1261-83
    • Calò, G.1    Guerrini, R.2    Rizzi, A.3    Salvadori, S.4    Regoli, D.5
  • 4
    • 0033821476 scopus 로고    scopus 로고
    • Tissue distribution of the opioid receptor-like (ORL1) receptor
    • Mollereau C, Mouledous L. Tissue distribution of the opioid receptor-like (ORL1) receptor. Peptides 2000 21 : 907 17.
    • (2000) Peptides , vol.21 , pp. 907-17
    • Mollereau, C.1    Mouledous, L.2
  • 5
    • 0032899946 scopus 로고    scopus 로고
    • Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility
    • Yazdani A, Takahashi T, Bagnol D. Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility. Gastroenterology 1999 116 : 108 17.
    • (1999) Gastroenterology , vol.116 , pp. 108-17
    • Yazdani, A.1    Takahashi, T.2    Bagnol, D.3
  • 6
    • 0031850510 scopus 로고    scopus 로고
    • Distribution of orphanin FQ in rat: An immunohistochemical study
    • Mitsuma T, Rhue N, Kayama M. Distribution of orphanin FQ in rat: an immunohistochemical study. Med Sci Res 1998 26 : 403 5.
    • (1998) Med Sci Res , vol.26 , pp. 403-5
    • Mitsuma, T.1    Rhue, N.2    Kayama, M.3
  • 7
    • 0030011981 scopus 로고    scopus 로고
    • Immunohistochemical localization of ORL-1 in the central nervous system of the rat
    • Anton B, Fein J, To T, Silberstein L, Evans CL. Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J Comp Neurol 1996 368 : 229 51.
    • (1996) J Comp Neurol , vol.368 , pp. 229-51
    • Anton, B.1    Fein, J.2    To, T.3    Silberstein, L.4    Evans, C.L.5
  • 8
    • 0344631766 scopus 로고    scopus 로고
    • Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with 125I-(14Tyr)-orphaninFQ binding
    • Neal CR, Jr., Mansour A, Reinsheid R. Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with 125I-(14Tyr)-orphaninFQ binding. J Comp Neurol 1999 412 : 563 605.
    • (1999) J Comp Neurol , vol.412 , pp. 563-605
    • Neal Jr., C.R.1    Mansour, A.2    Reinsheid, R.3
  • 9
    • 0034644471 scopus 로고    scopus 로고
    • Autoradiographic localization of [H3]nociceptin binding sites in the rat brain
    • Florin S, Meunier JC, Costentin J. Autoradiographic localization of [H3]nociceptin binding sites in the rat brain. Brain Res 2000 880 : 11 6.
    • (2000) Brain Res , vol.880 , pp. 11-6
    • Florin, S.1    Meunier, J.C.2    Costentin, J.3
  • 10
    • 0038167832 scopus 로고    scopus 로고
    • Distribution of ORL-1 receptor binding and receptor-activated G-proteins in rat forebrain and their experimental localization in anterior cingulate cortex
    • Sim-Selley LJ, Vogt LJ, Childers SR, Vogt BA. Distribution of ORL-1 receptor binding and receptor-activated G-proteins in rat forebrain and their experimental localization in anterior cingulate cortex. Neuropharmacology 2003 45 : 220 30.
    • (2003) Neuropharmacology , vol.45 , pp. 220-30
    • Sim-Selley, L.J.1    Vogt, L.J.2    Childers, S.R.3    Vogt, B.A.4
  • 11
    • 0023870025 scopus 로고
    • Roles of central and peripheral mu, delta and kappa receptors in the mediation of gastric motor and secretory effects in the rat
    • Fox D, Burks TF. Roles of central and peripheral mu, delta and kappa receptors in the mediation of gastric motor and secretory effects in the rat. J Pharmacol Exp Ther 1988 244 : 456 62.
    • (1988) J Pharmacol Exp Ther , vol.244 , pp. 456-62
    • Fox, D.1    Burks, T.F.2
  • 12
    • 0028170443 scopus 로고
    • 2 opioid receptor agonists on gastric functions in the rat
    • 2 opioid receptor agonists on gastric functions in the rat. Neuropharmacology 1994 33 : 977 81.
    • (1994) Neuropharmacology , vol.33 , pp. 977-81
    • Improta, G.1    Broccardo, M.2
  • 13
    • 0033821357 scopus 로고    scopus 로고
    • Orphanin FQ/nociceptin: A novel neuromodulator of gastrointestinal function?
    • Osinski MA, Brown DR. Orphanin FQ/nociceptin: a novel neuromodulator of gastrointestinal function? Peptides 2000 21 : 999 1005.
    • (2000) Peptides , vol.21 , pp. 999-1005
    • Osinski, M.A.1    Brown, D.R.2
  • 14
    • 0032896360 scopus 로고    scopus 로고
    • Peripheral and central actions of Orphanin FQ (Nociceptin) on murine colon
    • Osinski MA, Bass P, Gaumnitz EA. Peripheral and central actions of Orphanin FQ (Nociceptin) on murine colon. Am J Physiol 1999 193 : G125 31.
    • (1999) Am J Physiol , vol.193
    • Osinski, M.A.1    Bass, P.2    Gaumnitz, E.A.3
  • 15
    • 0032796883 scopus 로고    scopus 로고
    • In vitro agonist effects of nociceptin and (Phe1 (CH2-NH)Gly2) nociceptin(1-13)NH2 in the mouse and rat colon and mouse vas deferens
    • Menzies JRW, Glen T, Davies MRP, Paterson SJ, Corbett AD. In vitro agonist effects of nociceptin and (Phe1 (CH2-NH)Gly2) nociceptin(1-13)NH2 in the mouse and rat colon and mouse vas deferens. Eur J Pharmacol 1999 385 : 217 23.
    • (1999) Eur J Pharmacol , vol.385 , pp. 217-23
    • Menzies, J.R.W.1    Glen, T.2    Davies, M.R.P.3    Paterson, S.J.4    Corbett, A.D.5
  • 16
    • 0033769768 scopus 로고    scopus 로고
    • Orphanin FQ causes contractions via inhibiting purinergic pathway in the rat colon
    • Takahashi T, Bagnol D, Schneider D, et al. Orphanin FQ causes contractions via inhibiting purinergic pathway in the rat colon. Gastroenterology 2000 119 : 1054 63.
    • (2000) Gastroenterology , vol.119 , pp. 1054-63
    • Takahashi, T.1    Bagnol, D.2    Schneider, D.3
  • 17
    • 0036843128 scopus 로고    scopus 로고
    • Antagonistic effects of CompB on orphaninFQ-induced colonic contractions in rats
    • Tada H, Nakagawa K, Yamamura T, Takahashi T. Antagonistic effects of CompB on orphaninFQ-induced colonic contractions in rats. Eur J Pharmacol 2002 454 : 53 8.
    • (2002) Eur J Pharmacol , vol.454 , pp. 53-8
    • Tada, H.1    Nakagawa, K.2    Yamamura, T.3    Takahashi, T.4
  • 18
    • 33846533692 scopus 로고    scopus 로고
    • Effects of nociceptin/orphaninFQ on rats with cathartic colon
    • Li HY, Yan X, Xue QL, et al. Effects of nociceptin/orphaninFQ on rats with cathartic colon. World Gastroenterol 2007 13 : 141 5.
    • (2007) World Gastroenterol , vol.13 , pp. 141-5
    • Li, H.Y.1    Yan, X.2    Xue, Q.L.3
  • 19
    • 0033956029 scopus 로고    scopus 로고
    • Nociceptin inhibits tonic nitric oxide release in the mouse isolated proximal colon
    • Menzies JRW, Corbett AD. Nociceptin inhibits tonic nitric oxide release in the mouse isolated proximal colon. Eur J Pharmacol 2000 388 : 183 6.
    • (2000) Eur J Pharmacol , vol.388 , pp. 183-6
    • Menzies, J.R.W.1    Corbett, A.D.2
  • 20
    • 0032563324 scopus 로고    scopus 로고
    • The effect of nociceptin, an endogenous ligand for the ORL1 receptor, on rat colonic contraction and transit
    • Taniguchi H, Yomota E, Nogi K, Onoda Y, Ikezawa K. The effect of nociceptin, an endogenous ligand for the ORL1 receptor, on rat colonic contraction and transit. Eur J Pharmacol 1998 353 : 265 71.
    • (1998) Eur J Pharmacol , vol.353 , pp. 265-71
    • Taniguchi, H.1    Yomota, E.2    Nogi, K.3    Onoda, Y.4    Ikezawa, K.5
  • 21
    • 0034234793 scopus 로고    scopus 로고
    • OrphaninFQ but not dynorphin A, accelerates colonic transit in rats
    • Takahashi T, Mizuta Y, Owyang C. OrphaninFQ but not dynorphin A, accelerates colonic transit in rats. Gastroenterology 2000 119 : 71 9.
    • (2000) Gastroenterology , vol.119 , pp. 71-9
    • Takahashi, T.1    Mizuta, Y.2    Owyang, C.3
  • 22
    • 2942565819 scopus 로고    scopus 로고
    • Gastrointestinal effects of i.c.v. injected nociceptin/orphaninFQ in rats
    • Broccardo M, Guerrini R, Petrella C, Improta G. Gastrointestinal effects of i.c.v. injected nociceptin/orphaninFQ in rats. Peptides 2004 25 : 1013 20.
    • (2004) Peptides , vol.25 , pp. 1013-20
    • Broccardo, M.1    Guerrini, R.2    Petrella, C.3    Improta, G.4
  • 23
    • 23844477614 scopus 로고    scopus 로고
    • The effects of (Arg14, Lys15)nociceptin/orphaninFQ, a highly potent agonist of the NOP receptor, on in vitro and in vivo gastrointestinal functions
    • Broccardo M, Linari G, Guerrini R, Agostini S, Petrella C, Improta G. The effects of (Arg14, Lys15)nociceptin/orphaninFQ, a highly potent agonist of the NOP receptor, on in vitro and in vivo gastrointestinal functions. Peptides 2005 26 : 1590 7.
    • (2005) Peptides , vol.26 , pp. 1590-7
    • Broccardo, M.1    Linari, G.2    Guerrini, R.3    Agostini, S.4    Petrella, C.5    Improta, G.6
  • 24
    • 34248645417 scopus 로고    scopus 로고
    • Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha-alpha-dialkylated amino acids
    • Arduin M, Spagnolo B, Calo' G, et al. Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha-alpha-dialkylated amino acids. Bioorg Med Chem 2007 15 : 4434 43.
    • (2007) Bioorg Med Chem , vol.15 , pp. 4434-43
    • Arduin, M.1    Spagnolo, B.2    Calo, G.3
  • 25
    • 34249663768 scopus 로고    scopus 로고
    • In vitro and in vivo studies on UFP-112, a novel potent and selective peptide agonist selective for the nociceptin/orphanin FQ receptor
    • Rizzi A, Spagnolo B, Wainford RD, et al. In vitro and in vivo studies on UFP-112, a novel potent and selective peptide agonist selective for the nociceptin/orphanin FQ receptor. Peptides 2007 28 : 1240 51.
    • (2007) Peptides , vol.28 , pp. 1240-51
    • Rizzi, A.1    Spagnolo, B.2    Wainford, R.D.3
  • 26
    • 12244301594 scopus 로고    scopus 로고
    • UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: Radiologand and GTPg 35S binding studies
    • Mc Donald J, Calò G, Guerrini R, Lambert DG. UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: radiologand and GTPg 35S binding studies. N S Arch Pharmacol 2003 367 : 183 7.
    • (2003) N S Arch Pharmacol , vol.367 , pp. 183-7
    • Mc Donald, J.1    Calò, G.2    Guerrini, R.3    Lambert, D.G.4
  • 27
    • 24644442166 scopus 로고    scopus 로고
    • UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor
    • Calò G, Guerrini R, Rizzi A, et al. UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor. CNS Drug Rev 2005 11 : 97 112.
    • (2005) CNS Drug Rev , vol.11 , pp. 97-112
    • Calò, G.1    Guerrini, R.2    Rizzi, A.3
  • 28
    • 34548698179 scopus 로고    scopus 로고
    • The gastric effects of UFP 112, a new NOP receptor agonist, in physiological and pathological conditions
    • Broccardo M, Petrella C, Agostini S, Morini G, Polidori C, Improta G. The gastric effects of UFP 112, a new NOP receptor agonist, in physiological and pathological conditions. Peptides 2007 28 : 1974 81.
    • (2007) Peptides , vol.28 , pp. 1974-81
    • Broccardo, M.1    Petrella, C.2    Agostini, S.3    Morini, G.4    Polidori, C.5    Improta, G.6
  • 29
    • 0023582964 scopus 로고
    • Colonic bead expulsion time in normal and mu-opioid deficient mice following central administration of mu- and delta-opiod agonists
    • Raffa RB, Mathiasen JR, Jacoby HI. Colonic bead expulsion time in normal and mu-opioid deficient mice following central administration of mu- and delta-opiod agonists. Life Sci 1987 41 : 2229 34.
    • (1987) Life Sci , vol.41 , pp. 2229-34
    • Raffa, R.B.1    Mathiasen, J.R.2    Jacoby, H.I.3
  • 30
    • 0021248804 scopus 로고
    • The castor oil test in rats: An in vivo method to evaluate antipropulsive and antisecretory activity of antidiarrheals?
    • Niemegeers CJE, Awouters F, Janssen PAJ. The castor oil test in rats: an in vivo method to evaluate antipropulsive and antisecretory activity of antidiarrheals? Drug Dev Res 1984 4 : 223 7.
    • (1984) Drug Dev Res , vol.4 , pp. 223-7
    • Niemegeers, C.J.E.1    Awouters, F.2    Janssen, P.A.J.3
  • 31
    • 0035793932 scopus 로고    scopus 로고
    • Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats
    • Martinez V, Tachè Y. Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats. Brain Research 2001 893 : 29 35.
    • (2001) Brain Research , vol.893 , pp. 29-35
    • Martinez, V.1    Tachè, Y.2
  • 32
    • 0034465652 scopus 로고    scopus 로고
    • Peripheral CRF and stress-stimulated colonic motor activity involve type 1 receptor in rats
    • Maillot C, Million M, Wei JY, Gauthier A, Tachè Y. Peripheral CRF and stress-stimulated colonic motor activity involve type 1 receptor in rats. Gastroenterology 2000 119 : 1569 79.
    • (2000) Gastroenterology , vol.119 , pp. 1569-79
    • Maillot, C.1    Million, M.2    Wei, J.Y.3    Gauthier, A.4    Tachè, Y.5
  • 33
    • 0032858466 scopus 로고    scopus 로고
    • Nitrergic regulation of colonic transit in rats
    • Mizuta Y, Takahashi T, Owyang C. Nitrergic regulation of colonic transit in rats. Am J Physiol 1999 277 : G275 9.
    • (1999) Am J Physiol , vol.277
    • Mizuta, Y.1    Takahashi, T.2    Owyang, C.3
  • 34
    • 1942421154 scopus 로고    scopus 로고
    • The defecation reflex in rats: Fundamental properties and the reflex center
    • Nagano M, Ishimizu Y, Saitoh S, Okada H, Fukuda H. The defecation reflex in rats: fundamental properties and the reflex center. Auton Neurosci 2004 111 : 48 56.
    • (2004) Auton Neurosci , vol.111 , pp. 48-56
    • Nagano, M.1    Ishimizu, Y.2    Saitoh, S.3    Okada, H.4    Fukuda, H.5
  • 35
    • 0034703464 scopus 로고    scopus 로고
    • Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats
    • Million M, Wang L, Martinez V, Tachè Y. Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats. Brain Res 2000 877 : 345 53.
    • (2000) Brain Res , vol.877 , pp. 345-53
    • Million, M.1    Wang, L.2    Martinez, V.3    Tachè, Y.4
  • 36
    • 2342482993 scopus 로고    scopus 로고
    • Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function
    • Tachè Y, Perdue MH. Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function. Neurogastroenterol Motil 2004 1 : 137 42.
    • (2004) Neurogastroenterol Motil , vol.1 , pp. 137-42
    • Tachè, Y.1    Perdue, M.H.2
  • 38
    • 0023837989 scopus 로고
    • Stress-induced changes in intestinal transit in the rat: A model for irritable bowel syndrome
    • Williams CL, Villar RG, Peterson JM, Burks TF. Stress-induced changes in intestinal transit in the rat: a model for irritable bowel syndrome. Gastroenterology 1988 94 : 611 21.
    • (1988) Gastroenterology , vol.94 , pp. 611-21
    • Williams, C.L.1    Villar, R.G.2    Peterson, J.M.3    Burks, T.F.4
  • 39
    • 0026612742 scopus 로고
    • Role of the serotonin 3 receptor in stress-induced defecation
    • Miyata K, Kamato T, Nishida A, et al. Role of the serotonin 3 receptor in stress-induced defecation. J Pharmacol Exp Ther 1992 261 : 297 303.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 297-303
    • Miyata, K.1    Kamato, T.2    Nishida, A.3
  • 40
    • 0032796883 scopus 로고    scopus 로고
    • In vitro agonist effects of nociceptin and (Phe1 (CH2-NH)Gly2) nociceptin(1-13)NH2 in the mouse and rat colon and mouse vas deferens
    • Menzies JRW, Glen T, Davies MRP, Paterson SJ, Corbett AD. In vitro agonist effects of nociceptin and (Phe1 (CH2-NH)Gly2) nociceptin(1-13)NH2 in the mouse and rat colon and mouse vas deferens. Eur J Pharmacol 1999 385 : 217 23.
    • (1999) Eur J Pharmacol , vol.385 , pp. 217-23
    • Menzies, J.R.W.1    Glen, T.2    Davies, M.R.P.3    Paterson, S.J.4    Corbett, A.D.5
  • 41
    • 0037251823 scopus 로고    scopus 로고
    • Nociceptin/orphanin FQ content is decreased in Forebrain neurones during acute stress
    • Devine DP, Hoversten MT, Ueda Y, Akil H. Nociceptin/orphanin FQ content is decreased in Forebrain neurones during acute stress. J Neuroendocrinology 2003 15 : 69 74.
    • (2003) J Neuroendocrinology , vol.15 , pp. 69-74
    • Devine, D.P.1    Hoversten, M.T.2    Ueda, Y.3    Akil, H.4
  • 42
    • 34347266481 scopus 로고    scopus 로고
    • The nociceptin/orphanin FQ antagonist UFP-101 differentially modulates the glucocorticoid response to restraint stress in rats during the peak and nadir phases of the hypothalamo-pituitary-adrenal axis circadian rhythm
    • Leggett JD, Jessop DS, Fulford AJ. The nociceptin/orphanin FQ antagonist UFP-101 differentially modulates the glucocorticoid response to restraint stress in rats during the peak and nadir phases of the hypothalamo-pituitary-adrenal axis circadian rhythm. Neuroscience 2007 147 : 757 64.
    • (2007) Neuroscience , vol.147 , pp. 757-64
    • Leggett, J.D.1    Jessop, D.S.2    Fulford, A.J.3
  • 43
    • 0036961118 scopus 로고    scopus 로고
    • Role of corticotrophin releasing factor receptor subtype I in stress-related functional colonic alterations: Implications in irritable bowel syndrome
    • Tachè Y, Martinez V, Million M, Maillot C. Role of corticotrophin releasing factor receptor subtype I in stress-related functional colonic alterations: implications in irritable bowel syndrome. Eur J Surg 2002 168 : 16 22.
    • (2002) Eur J Surg , vol.168 , pp. 16-22
    • Tachè, Y.1    Martinez, V.2    Million, M.3    Maillot, C.4
  • 44
    • 0035793932 scopus 로고    scopus 로고
    • Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats
    • Martinez V, Tachè Y. Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats. Brain Res 2001 893 : 29 35.
    • (2001) Brain Res , vol.893 , pp. 29-35
    • Martinez, V.1    Tachè, Y.2
  • 45
    • 33744817202 scopus 로고    scopus 로고
    • Restraint stress-induced acceleration of colonic transit is mediated via a central CRF and intraluminal 5HT3 receptors in conscious rats
    • Nakade Y, Fukuda H, Iwa M, Pappas T, Takahashi T. Restraint stress-induced acceleration of colonic transit is mediated via a central CRF and intraluminal 5HT3 receptors in conscious rats. Gastroenterology 2005 128 : A115 21.
    • (2005) Gastroenterology , vol.128
    • Nakade, Y.1    Fukuda, H.2    Iwa, M.3    Pappas, T.4    Takahashi, T.5
  • 46
    • 0035008662 scopus 로고    scopus 로고
    • Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: Role of brain corticotrophin-releasing factor receptors
    • Tachè Y, Martinez V, Million M, Wang L. Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotrophin-releasing factor receptors. Am J Physiol 2001 280 : G173 7.
    • (2001) Am J Physiol , vol.280
    • Tachè, Y.1    Martinez, V.2    Million, M.3    Wang, L.4
  • 47
    • 33644513738 scopus 로고    scopus 로고
    • Antidepressant- and anxiolytic-like effects of nociceptin/orphanin FQ receptor ligands
    • Gavioli EC, Calo' G. Antidepressant- and anxiolytic-like effects of nociceptin/orphanin FQ receptor ligands. N S Arch Pharmacol 2006 372 : 319 30.
    • (2006) N S Arch Pharmacol , vol.372 , pp. 319-30
    • Gavioli, E.C.1    Calo, G.2
  • 48
    • 0037802203 scopus 로고    scopus 로고
    • Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
    • Koster A, Montkowski A, Schulz S, et al. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice. Proc Natl Acad Sci USA 1999 96 : 10444 9.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10444-9
    • Koster, A.1    Montkowski, A.2    Schulz, S.3
  • 49
    • 1042300320 scopus 로고    scopus 로고
    • Behavioral and endocrine changes following antisense oligonucleotide- induced reduction in the rat NOP receptor
    • Blakley GG, Pohorecky LA, Benjamin D. Behavioral and endocrine changes following antisense oligonucleotide-induced reduction in the rat NOP receptor. Psychopharmacology (Berl) 2004 171 : 421 8.
    • (2004) Psychopharmacology (Berl) , vol.171 , pp. 421-8
    • Blakley, G.G.1    Pohorecky, L.A.2    Benjamin, D.3
  • 50
    • 0031463956 scopus 로고    scopus 로고
    • Orphanin FQ acts as an anxiolytic to attenuate behavioural responses to stress
    • Jenck F, Moreau JL, Martin JR, et al. Orphanin FQ acts as an anxiolytic to attenuate behavioural responses to stress. Proc Natl Acad Sci USA 1997 94 : 14854 8.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14854-8
    • Jenck, F.1    Moreau, J.L.2    Martin, J.R.3
  • 51
    • 0034712756 scopus 로고    scopus 로고
    • A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: Anxiolytic profile in the rat
    • Jenck F, Wichmann J, Dautzenberg FM, et al. A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat. Proc Natl Acad Sci USA 2000 979 : 4938 43.
    • (2000) Proc Natl Acad Sci USA , vol.979 , pp. 4938-43
    • Jenck, F.1    Wichmann, J.2    Dautzenberg, F.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.