The effects of [Arg14, Lys15] nociceptin/orphanin FQ, a highly potent agonist of the NOP receptor, on in vitro and in vivo gastrointestinal functions

Peptides

Volumn 26, Issue 9, 2005, Pages 1590-1597

  Broccardo, M ^a   Linari, G ^a   Guerrini, R ^b   Agostini, S ^a   Petrella, C ^a   Improta, G ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Arg14, Lys15 N OFQ; Gastrointestinal motor and secretory functions

Indexed keywords

NOCICEPTIN; NOCICEPTIN DERIVATIVE; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR AGONIST; NOCICEPTIN RECEPTOR ANTAGONIST; PHENOLSULFONPHTHALEIN; POTASSIUM CHLORIDE; (NPHE(1),ARG(14),LYS(15))N OFQ NH(2); (NPHE(1),ARG(14),LYS(15))N-OFQ NH(2); AMYLASE; NALOXONE; NOCICEPTIN, ARG(14) LYS(15); NOCICEPTIN, ARG(14)-LYS(15)-; OPIATE PEPTIDE; OPIATE RECEPTOR; VASODILATOR AGENT;

AMYLASE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG POTENCY; GASTROINTESTINAL TRACT FUNCTION; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN FUNCTION; PYLORUS LIGATION; RAT; STOMACH ACID SECRETION; STOMACH EMPTYING; WATER LOADING; ANIMAL; DIGESTIVE SYSTEM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GASTROINTESTINAL TRANSIT; LIGATION; PYLORUS; SECRETION; STOMACH ACID; STOMACH MUCOSA; WISTAR RAT;

CAVIA PORCELLUS;

AMYLASES; ANIMALS; DIGESTIVE SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC ACID; GASTRIC EMPTYING; GASTRIC MUCOSA; GASTROINTESTINAL TRANSIT; GUINEA PIGS; LIGATION; MALE; NALOXONE; OPIOID PEPTIDES; PANCREAS, EXOCRINE; POTASSIUM CHLORIDE; PYLORUS; RATS; RATS, WISTAR; RECEPTORS, OPIOID; VASODILATOR AGENTS;

EID: 23844477614     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.02.018     Document Type: Article

References (30)

1. M. Broccardo, R. Guerrini, C. Petrella, and G. Improta Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphanin FQ in rats Peptides 25 2004 1013 1020
2. J.R. Bunzow, C. Saez, M. Mortrud, C. Bouvier, J.T. Williams, and M. Low Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type FEBS Lett 347 1994 284 288
3. G. Calò, R. Guerrini, A. Rizzi, S. Salvadori, and D. Regoli Pharmacology of nociceptin and its receptor: a novel therapeutic target Br J Pharmacol 129 2000 1261 1283
4. 15] nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor Br J Pharmacol 136 2002 303 311
5. D. Fox, and T.F. Burks Roles of central and peripheral mu, delta and kappa receptors in the mediation of gastric motor and secretory effects in the rat J Pharmacol Exp Ther 244 1988 456 462
6. G. Improta, M. Broccardo, A. Lisi, and P. Melchiorri Neural regulation of gastric acid secretion in rats: influence of dermorphin Regul Pept 3 1982 251 256
7. 2 opioid receptor agonists on gastric functions in the rat Neuropharmacology 33 1994 977 981
8. S. Ishihara, S. Minowa, S. Tsuchiya, S. Horie, K. Watanabe, and T. Murayama Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats Eur J Pharmacol 44 2002 105 114
9. 2 stimulate gastric motor function in anaesthetized rats Br J Pharmacol 130 2000 1639 1645
10. K. Lorentz Approved recommendations on IFCC methods for measurement of catalitic concentration of enzymes Clin Chem Lab Med 36 1998 185 203
11. D.S. Louie, H.T. Chen, and C. Owyang Inhibition of exocrine pancreatic secretion by opiates is mediated by suppression of cholinergic transmission: characterization of receptor subtypes J Pharmacol Exp Ther 246 1988 132 136
12. J. Mc Donald, G. Calò, R. Guerrini, and D.G. Lambert UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: radiologand and GTPg 35S binding studies Naunyn Schmiedebergs Arch Pharmacol 367 2003 183 187
13. J.R. Menzies, and A.D. Corbett Nociceptin inhibits tonic nitric oxide release in the mouse isolated proximal colon Eur J Pharmacol 388 2000 183 186
14. J.C. Meunier The potential therapeutic value of nociceptin receptor agonists and antagonists Exp Opin Ther Patents 10 2000 371 388
15. J.S. Mogil, and W. Pasternak The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide receptor family Pharmacol Rev 53 2001 381 415
16. C. Mollerau, and L. Mouledous Tissue distribution of the opioid receptor-like (ORL-1) receptor Peptides 21 2000 907 917
17. C.R. Neal Jr., A. Mansour, R. Reinscheid, H.P. Nothaker, O. Civelli, and H. Akil Opioid receptor-like (ORL-1) receptor distribution in the rat central nervous system: comparison of ORL-1 receptor mRNA expression with 125-I 14 Tyr-orphanin FQ binding J Comp Neurol 412 1999 563 605
18. K. Okada, T. Sujaku, Y. Chuman, and R. Nakashima Highly potent nociceptin analog containing the Arg-Lys triple repeat Biochem Biophys Res Commun 278 2000 493 498
19. M.A. Osinski, P. Bass, and E.A. Gaumnitz Peripheral and central actions of orphanin FQ (nociceptin) on murine colon Am J Physiol Gastrointest Liver Physiol 276 1999 G125 G131
20. M.A. Osinski, and D.R. Brown Orphanin FQ/nociceptin: a novel neuromodulator of gastrointestinal function Peptides 21 2000 999 1005
21. C. Polidori, G. de Caro, and M. Massi The hyperphagic effect of nociceptin/orphanin FQ in rats Peptides 21 2000 1051 1062
22. J.D. Pomonis, C.J. Billington, A.S. Levine, and F.Q. Orphanin Agonist of orphanin opioid receptor ORL-1, stimulates feeding in rats Neuroreport 8 1996 369 371
23. R.B. Raffa, J.R. Mathiasen, and H.I. Jacoby Colonic bead expulsion time in normal and mu-opioid deficient mice following central administration of mu- and delta-opiod agonists Life Sci 41 1987 2229 2234
24. 15] nociceptin, a higly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies J Pharmacol Exp Ther 300 2002 57 63
25. C. Rouget, Y.Y. Cui, B. D'Agostino, C. Faisy, E. Naline, and M. Bardou Nociceptin inhibits airway microvascular leakage by HCl intra-oesophageal instillation Br J Pharmacol 141 2004 1077 1083
26. C. Scarpignato, T. Capovilla, and G. Bertaccini Action of caerulein on gastric emptying of the conscious rat Arch Int Pharmacod Ther 246 1980 286 294
27. A.G. Scheele, and G.E. Palade Parallel discharge of exocrine enzyme activities J Biol Chem 250 1975 2660 2675
28. J. Tack, and P.V. Berghe Neuropeptides and colonic motility: it's all in the little brain Gastroenterology 119 2000 257 260
29. T. Takahashi, Y. Mizuta, and C. Owyang Orphanin FQ but not dynorphin A accelerates colonic transit in rats Gastroenterology 119 2000 71 79
30. A. Yazdani, T. Takahashi, D. Bagnol, S.J. Watson, and C. Owyang Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility Gastroenterology 116 1999 108 117