메뉴 건너뛰기




Volumn 51, Issue 2, 2008, Pages 130-136

HBx inhibits the growth of CCL13-HBX-stable cells via the GSK-3β/β-catenin cascade

Author keywords

GSK 3 catenin cascade; Hepatitis B virus X protein; Proliferation

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; HEPATITIS B VIRUS X PROTEIN; WNT3 PROTEIN;

EID: 47549097753     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000139131     Document Type: Article
Times cited : (8)

References (47)
  • 1
    • 0347479386 scopus 로고    scopus 로고
    • Detection of the hepatitis B virus X protein (HBx) antigen and anti-HBx antibodies in cases of human hepatocellular carcinoma
    • Hwang GY, Lin CY, Huang LM, Wang YH, Wang JC, Hsu CT, Yang SS, Wu CC: Detection of the hepatitis B virus X protein (HBx) antigen and anti-HBx antibodies in cases of human hepatocellular carcinoma. J Clin Microbiol 2003;41:5598-5603.
    • (2003) J Clin Microbiol , vol.41 , pp. 5598-5603
    • Hwang, G.Y.1    Lin, C.Y.2    Huang, L.M.3    Wang, Y.H.4    Wang, J.C.5    Hsu, C.T.6    Yang, S.S.7    Wu, C.C.8
  • 2
    • 1842850952 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity of the hepatitis B virus X gene in Chang liver cell line
    • Wang JC, Hsu SL, Hwang GY: Inhibition of tumorigenicity of the hepatitis B virus X gene in Chang liver cell line. Virus Res 2004;102:133-139.
    • (2004) Virus Res , vol.102 , pp. 133-139
    • Wang, J.C.1    Hsu, S.L.2    Hwang, G.Y.3
  • 3
    • 33748288087 scopus 로고    scopus 로고
    • Molecular functions and biological roles of hepatitis B virus X protein
    • Tang H, Oishi N, Kaneko S, Murakami S: Molecular functions and biological roles of hepatitis B virus X protein. Cancer Sci 2006;97:977-983.
    • (2006) Cancer Sci , vol.97 , pp. 977-983
    • Tang, H.1    Oishi, N.2    Kaneko, S.3    Murakami, S.4
  • 4
    • 34248674146 scopus 로고    scopus 로고
    • WNT/beta-catenin signaling in liver health and disease
    • Thompson MD, Monga SP: WNT/beta-catenin signaling in liver health and disease. Hepatology 2007;45:1298-1305.
    • (2007) Hepatology , vol.45 , pp. 1298-1305
    • Thompson, M.D.1    Monga, S.P.2
  • 5
    • 0142028054 scopus 로고    scopus 로고
    • GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular carcinoma
    • Ban KC, Singh H, Krishnan R, Seow HF: GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular carcinoma. Cancer Lett 2003;199:201-208.
    • (2003) Cancer Lett , vol.199 , pp. 201-208
    • Ban, K.C.1    Singh, H.2    Krishnan, R.3    Seow, H.F.4
  • 8
    • 18844402131 scopus 로고    scopus 로고
    • Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer
    • Calvisi DF, Conner EA, Ladu S, Lemmer ER, Factor VM, Thorgeirsson SS: Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. J Hepatol 2005;42:842-849.
    • (2005) J Hepatol , vol.42 , pp. 842-849
    • Calvisi, D.F.1    Conner, E.A.2    Ladu, S.3    Lemmer, E.R.4    Factor, V.M.5    Thorgeirsson, S.S.6
  • 10
    • 2542546650 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells
    • Cha MY, Kim CM, Park YM, Ryu WS: Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatology 2004;39:1683-1693.
    • (2004) Hepatology , vol.39 , pp. 1683-1693
    • Cha, M.Y.1    Kim, C.M.2    Park, Y.M.3    Ryu, W.S.4
  • 12
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble BW, Woodgett JR: GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 2003;116:1175-1186.
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 13
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope RS, Johnson GV: The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 2004;29:95-102.
    • (2004) Trends Biochem Sci , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2
  • 15
    • 0031972604 scopus 로고    scopus 로고
    • X-gene product of hepatitis B virus induces apoptosis in liver cells
    • Kim H, Lee H, Yun Y: X-gene product of hepatitis B virus induces apoptosis in liver cells. J Biol Chem 1998;273:381-385.
    • (1998) J Biol Chem , vol.273 , pp. 381-385
    • Kim, H.1    Lee, H.2    Yun, Y.3
  • 16
    • 33646114053 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression
    • Miao J, Chen GG, Chun SY, Lai PP: Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression. Cancer Lett 2006;236:115-124.
    • (2006) Cancer Lett , vol.236 , pp. 115-124
    • Miao, J.1    Chen, G.G.2    Chun, S.Y.3    Lai, P.P.4
  • 19
    • 0034739918 scopus 로고    scopus 로고
    • Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein
    • Su F, Theodosis CN, Schneider RJ: Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein. J Virol 2001;75:215-225.
    • (2001) J Virol , vol.75 , pp. 215-225
    • Su, F.1    Theodosis, C.N.2    Schneider, R.J.3
  • 20
    • 0030787584 scopus 로고    scopus 로고
    • Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha
    • Su F, Schneider RJ: Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc Natl Acad Sci USA 1997;94:8744-8749.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8744-8749
    • Su, F.1    Schneider, R.J.2
  • 23
    • 35548936963 scopus 로고    scopus 로고
    • Hepatocytes treated with HBV X protein as cytotoxic effectors kill primary hepatocytes by TNF-alpha-related apoptosis-induced ligand-mediated mechanism
    • Yang Y, Zheng L, Lv G, Jin X, Sheng J: Hepatocytes treated with HBV X protein as cytotoxic effectors kill primary hepatocytes by TNF-alpha-related apoptosis-induced ligand-mediated mechanism. Intervirology 2007;50:323-327.
    • (2007) Intervirology , vol.50 , pp. 323-327
    • Yang, Y.1    Zheng, L.2    Lv, G.3    Jin, X.4    Sheng, J.5
  • 24
    • 0033607041 scopus 로고    scopus 로고
    • Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx
    • Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Brechot C: Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 1999;18:4848-4859.
    • (1999) Oncogene , vol.18 , pp. 4848-4859
    • Sirma, H.1    Giannini, C.2    Poussin, K.3    Paterlini, P.4    Kremsdorf, D.5    Brechot, C.6
  • 25
    • 13244265798 scopus 로고    scopus 로고
    • Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance
    • Doucas H, Garcea G, Neal CP, Manson MM, Berry DP: Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance. Eur J Cancer 2005;41:365-379.
    • (2005) Eur J Cancer , vol.41 , pp. 365-379
    • Doucas, H.1    Garcea, G.2    Neal, C.P.3    Manson, M.M.4    Berry, D.P.5
  • 26
    • 41749093180 scopus 로고    scopus 로고
    • Effects of hepatitis B virus X protein (HBx) on cell-growth inhibition in a CCL13-HBx stable cell line
    • Kuo CY, Wang JC, Wu CC, Hsu SL, Hwang GY: Effects of hepatitis B virus X protein (HBx) on cell-growth inhibition in a CCL13-HBx stable cell line. Intervirology 2008;51:26-32.
    • (2008) Intervirology , vol.51 , pp. 26-32
    • Kuo, C.Y.1    Wang, J.C.2    Wu, C.C.3    Hsu, S.L.4    Hwang, G.Y.5
  • 27
    • 0035015867 scopus 로고    scopus 로고
    • Beta-catenin and its multiple partners: Promiscuity explained
    • Shapiro L: Beta-catenin and its multiple partners: promiscuity explained. Nat Struct Biol 2001;8:484-487.
    • (2001) Nat Struct Biol , vol.8 , pp. 484-487
    • Shapiro, L.1
  • 28
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    • Stambolic V, Ruel L, Woodgett JR: Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 1996;6:1664-1668.
    • (1996) Curr Biol , vol.6 , pp. 1664-1668
    • Stambolic, V.1    Ruel, L.2    Woodgett, J.R.3
  • 29
    • 0141794473 scopus 로고    scopus 로고
    • Regulation of glycogen synthase kinase 3 in human platelets: A possible role in platelet function?
    • Barry FA, Graham GJ, Fry MJ, Gibbins JM: Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function? FEBS Lett 2003;553:173-178.
    • (2003) FEBS Lett , vol.553 , pp. 173-178
    • Barry, F.A.1    Graham, G.J.2    Fry, M.J.3    Gibbins, J.M.4
  • 30
    • 33748702122 scopus 로고    scopus 로고
    • The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes
    • Tseng AS, Engel FB, Keating MT: The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol 2006;13:957-963.
    • (2006) Chem Biol , vol.13 , pp. 957-963
    • Tseng, A.S.1    Engel, F.B.2    Keating, M.T.3
  • 32
    • 0029964851 scopus 로고    scopus 로고
    • Signal transduction through beta-catenin and specification of cell fate during embryogenesis
    • Miller JR, Moon RT: Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev 1996;10:2527-2539.
    • (1996) Genes Dev , vol.10 , pp. 2527-2539
    • Miller, J.R.1    Moon, R.T.2
  • 33
    • 0041885325 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen (PCNA): A dancer with many partners
    • Maga G, Hubscher U: Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 2003;116:3051-3060.
    • (2003) J Cell Sci , vol.116 , pp. 3051-3060
    • Maga, G.1    Hubscher, U.2
  • 34
    • 32244445762 scopus 로고    scopus 로고
    • Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells
    • Chan DW, Ng IO: Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells. J Pathol 2006;208:372-380.
    • (2006) J Pathol , vol.208 , pp. 372-380
    • Chan, D.W.1    Ng, I.O.2
  • 35
    • 0042357131 scopus 로고    scopus 로고
    • Hepatitis B virus X protein activates a survival signaling by linking SRC to phosphatidylinositol 3-kinase
    • Shih WL, Kuo ML, Chuang SE, Cheng AL, Doong SL: Hepatitis B virus X protein activates a survival signaling by linking SRC to phosphatidylinositol 3-kinase. J Biol Chem 2003;278:31807-31813.
    • (2003) J Biol Chem , vol.278 , pp. 31807-31813
    • Shih, W.L.1    Kuo, M.L.2    Chuang, S.E.3    Cheng, A.L.4    Doong, S.L.5
  • 36
    • 0034682769 scopus 로고    scopus 로고
    • Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
    • Shih WL, Kuo ML, Chuang SE, Cheng AL, Doong SL: Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J Biol Chem 2000;275:25858-25864.
    • (2000) J Biol Chem , vol.275 , pp. 25858-25864
    • Shih, W.L.1    Kuo, M.L.2    Chuang, S.E.3    Cheng, A.L.4    Doong, S.L.5
  • 37
    • 34547600513 scopus 로고    scopus 로고
    • Hepatitis B virus X protein differentially affects the ubiquitin-mediated proteasomal degradation of beta-catenin depending on the status of cellular p53
    • Jung JK, Kwun HJ, Lee JO, Arora P, Jang KL: Hepatitis B virus X protein differentially affects the ubiquitin-mediated proteasomal degradation of beta-catenin depending on the status of cellular p53. J Gen Virol 2007;88:2144-2154.
    • (2007) J Gen Virol , vol.88 , pp. 2144-2154
    • Jung, J.K.1    Kwun, H.J.2    Lee, J.O.3    Arora, P.4    Jang, K.L.5
  • 38
  • 39
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/factor A
    • Woodgett JR: Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J 1990;9:2431-2438.
    • (1990) EMBO J , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 41
    • 16844374033 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells
    • Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD: Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res 2005;65:2076-2081.
    • (2005) Cancer Res , vol.65 , pp. 2076-2081
    • Ougolkov, A.V.1    Fernandez-Zapico, M.E.2    Savoy, D.N.3    Urrutia, R.A.4    Billadeau, D.D.5
  • 43
    • 0034175688 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal
    • Hetman M, Cavanaugh JE, Kimelman D, Xia Z: Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. J Neurosci 2000;20:2567-2574.
    • (2000) J Neurosci , vol.20 , pp. 2567-2574
    • Hetman, M.1    Cavanaugh, J.E.2    Kimelman, D.3    Xia, Z.4
  • 44
    • 33746239119 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells
    • Cao Q, Lu X, Feng YJ: Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells. Cell Res 2006;16:671-677.
    • (2006) Cell Res , vol.16 , pp. 671-677
    • Cao, Q.1    Lu, X.2    Feng, Y.J.3
  • 45
    • 0036081578 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
    • Schwabe RF, Brenner DA: Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002;283:204-211.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283 , pp. 204-211
    • Schwabe, R.F.1    Brenner, D.A.2
  • 46
    • 34447626493 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A key regulator of cellular fate
    • Forde JE, Dale TC: Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 2007;64:1930-1944.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 1930-1944
    • Forde, J.E.1    Dale, T.C.2
  • 47
    • 0036190970 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways
    • Manoukian AS, Woodgett JR: Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways. Adv Cancer Res 2002;84:203-229.
    • (2002) Adv Cancer Res , vol.84 , pp. 203-229
    • Manoukian, A.S.1    Woodgett, J.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.