Hepatocytes treated with HBV X protein as cytotoxic effectors kill primary hepatocytes by TNF-alpha-related apoptosis-induced ligand-mediated mechanism

Intervirology

Volumn 50, Issue 5, 2007, Pages 323-327

  Yang, Yida ^a   Zheng, Lin ^a   Lv, Guocai ^a   Jin, Xi ^a   Sheng, Jifang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Cytotoxic effect; HBV X protein (HBX); Primary hepatocytes; TNF related apoptosis induced ligand (TRAIL)

Indexed keywords

ANTIBODY; HBXD1 PROTEIN; HEPATITIS B VIRUS X PROTEIN; MESSENGER RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND ANTIBODY; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADULT; ARTICLE; ASSAY; CELL DEATH; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL; MALE; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; HEPATOCYTES; HUMANS; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANS-ACTIVATORS;

HEPATITIS B VIRUS; MAMMALIA;

EID: 35548936963     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000106463     Document Type: Article

References (28)

1. Seto E, Yen TS, Peterlin BM, Ou JH: Transactivation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein. Proc Natl Acad Sci USA 1988;85:8286-8290.
2. Wang HD, Trivedi A, Johnson DJ: Hepatitis B virus X protein induces RNA polymerase III-dependent gene transcription and increases cellular TATA-binding protein by activating the Ras signaling pathway. Mol Cell Biol 1997;7:6838-6846.
3. Wang HD, Trivedi A, Johnson DJ: Regulation of RNA polymerase I-dependent promoters by the hepatitis B virus X protein via activated Ras and TATA-binding protein. Mol Cell Biol 1998;18:7086-7094.
4. Cougot D, Wu Y, Cario S, Caramel J, Renard J, Levy L, Buendia MA, Neuveut C: The hepatitis B virus X protein functionally interacts with CBP/p300 in the regulation of CREB-mediated transcription. J Biol Chem 2006;16;282:4277-4287.
5. Wang XW: Microinjection technique used to study functional interaction between p53 and hepatitis B virus gene in apoptosis. Mol Biotechnol 2001;18:169-177.
6. Murakami S: Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol 2001;36:651-660.
7. Su F, Schneider RJ: Hepatitis B virus HBX protein sensitizes cells to apoptotic killing by tumor necrosis factor α . Proc Natl Acad Sci USA 1997;94:8744-8749.
8. Kim KH, Seong L: Pro-apoptotic function of HBX protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J 2003;22:2104-2116.
9. Lee AT, Ren J, Wong ET, Ban KH, Lee LA, Lee CG: The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage. J Biol Chem 2005;280:33525-33535.
10. Benn J, Schneider RJ: Hepatitis B virus HBX protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA 1994;91:10350-10354.
11. Wang WH, Gregori G, Hullinger RL, Andrisani OM: Sustained activation of p38 mitogen-activated protein kinase and c-jun N terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor receptor 1/TNF-α expression. Mol Cell Biol 2004;24:10352-10365.
12. Mahe Y, Mukaida N, Kuno K, Akiyama M, Ikeda N, Matsushima K, Murakami S: Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor-κB and CCAAT/enhancer-binding protein-like cis-elements. J Biol Chem 1991;266:13759-13763.
13. Lara-Pezzi E, Scrrador JM, Montoya MC, Zamora D, Yanez-Mo M, Carretero M, Furthmayr H, Sanchez-Madrid, Lopez-Cabrera M: The hepatitis B virus X protein induces a migratory phenotype in a CD44-dependent manner: possible role of HBX in invasion and metastasis. Hepatology 2001;33:1270-1281.
14. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991:66:233-243.
15. Suda T, Takahashi T, Golstein P, Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993;75:1169-1178.
16. Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A, Ashkenazi A: Induction of Apo-2 ligand, a new member of tumor necrosis factor cytokine family. J Biol Chem 1996;271:12687-12692.
17. Johnwen AC, Haux J, Steinkjer B, Nonstad U, Egeberg K, Sundan A, Ashkenazi A: Regulation of Apo-2 ligand/TRAIL expression in NK cells involvement in NK cell-mediated cytotoxicity. Cytokine 1999;11:664-672.
18. Tan KB, Harrop J, Reddy M, Young P, Terrett J, Emery J, Moore G, Truneh A: Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hepatopoietic and non-hematopoietic cells. Gene 1997;35-39.
19. Old TJ: Tumor necrosis factor. Science 1985;230:630-635.
20. Jo M, Kim TH, Seol DW, Esplen JE, Dorko K, Billiar TR, Strom S: Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 2000;6:564-567.
21. Zheng SJ, Wang P, Tsabary G, Chen YH: Critical roles of TRAIL in hepatic cell death and hepatic inflammation. J Clin Invest 2004;113:58-64.
22. Corazza N, Jakob S, Schaer C, Frese S, Keogh A, Stroka D, Kassen D, Torgler R, Mueller C, Schneider P, Brunner T: TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest 2006;116:2493-2499.
23. Murakami S, Cheong JH, Kaneko S: Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein. J Biol Chem 1994;47:485-487.
24. Lin Y, Nomura T, Cheong J, Dorjsuren D, Iida K, Murakami S: Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J Biol Chem 1997;14:7132-7139.
25. + cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism. J Virol 2003;77:6700-6708.
26. Yin C, Djavani M, Schenkel AR, Schmidt DS, Pauza CD, Salvato MS: Dissemination of LCMV from the gastric mucosa requires a protein coupled signaling. J Virol 1998;72:8613-8619.
27. Guy GS, Wang J, Michalak TI: Hepatocytes as cytotoxic effector cells can induce cell death by CD95 ligand-mediated pathway. Hepatology 2006;43:1231-1240.
28. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA: Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995;250:1189-1192.