A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice

Drug and Chemical Toxicology

Volumn 31, Issue 3, 2008, Pages 371-381

  Kassa, Jiri ^a,b   Karasova, Jana ^a   Musilek, Kamil ^a   Kuca, Kamil ^a,b   Jung, Young Sik ^c  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Acetylcholinesterase; HI 6; K117; K127; Mice; Obidoxime; Rats; Tabun; Trimedoxime

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ATROPINE; BIS(PYRIDINIUM OXIME) DERIVATIVE; K 117; K 127; OBIDOXIME; TABUN; TRIMEDOXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DIAPHRAGM; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; IN VIVO STUDY; INTOXICATION; LETHALITY; MALE; MOUSE; NONHUMAN; RAT; STATISTICAL ANALYSIS;

ACETYLCHOLINESTERASE; ANIMALS; ANTIDOTES; BRAIN; CHOLINESTERASE INHIBITORS; DIAPHRAGM; MALE; MICE; OBIDOXIME CHLORIDE; OXIMES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; TRIMEDOXIME;

MUS; RATTUS;

EID: 47549090639     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540802171258     Document Type: Article

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