Calcium signaling pathway involving calcineurin regulates interleukin-8 gene expression through activation of NF-κB in human osteoblast-like cells

Journal of Bone and Mineral Research

Volumn 19, Issue 4, 2004, Pages 671-679

  Mitsuyama, Hirohito ^a,b   Kambe, Fukushi ^a   Murakami, Ryuichiro ^a   Cao, Xia ^a   Ishiguro, Naoki ^b   Seo, Hisao ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcineurin; Calcium; Interleukin 8; NF B; TNF

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; CALCIUM; CALCIUM IONOPHORE; CYCLOSPORIN A; CYTOPLASM PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LUCIFERASE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; SYNAPTOTAGMIN; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA; ANTINEOPLASTIC AGENT; CALCIMYCIN; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; IONOPHORE;

ARTICLE; BINDING SITE; CALCIUM SIGNALING; CONTROLLED STUDY; CYTOKINE PRODUCTION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; OSTEOBLAST; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REPORTER GENE; WESTERN BLOTTING; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; GENETICS; METABOLISM;

ANTINEOPLASTIC AGENTS; CALCIMYCIN; CALCINEURIN; CALCIUM SIGNALING; CELL LINE; CYCLOSPORINE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-8; IONOPHORES; NF-KAPPA B; OSTEOBLASTS; PROMOTER REGIONS (GENETICS); TACROLIMUS; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 4744363419     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.0301256     Document Type: Article

References (44)

1. Mukaida N, Mahe Y, Matsushima K 1990 Cooperative interaction of nuclear factor-κB- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J Biol Chem 265:21128-21133.
2. Mahe Y, Mukaida N, Kuno K, Akiyama M, Ikeda N, Matsushima K, Murakami S 1991 Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor κB and CCAAT/enhancer-binding protein-like cis-elements. J Biol Chem 266:13759-13763.
3. Yasumoto K, Okamoto S, Mukaida N, Murakami S, Mai M, Matsushima K 1992 Tumor necrosis factor a and interferon γ synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-κB-like binding sites of the interleukin 8 gene. J Biol Chem 267:22506-22511.
4. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsushima K, Kishimoto T, Akira S 1993 Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90:10193-10197.
5. Baldwin AJ 1996 The NF-κB and I κB proteins: New discoveries and insights. Annu Rev Immunol 14:649-683.
6. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M 1997 The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243-252.
7. DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M, Roff M 1996 Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation: Role of IκBalpha ubiquitination in signal-induced activation of NFκB in vivo. Mol Cell Biol 16:1295-1304.
8. Chaudhary LR, Spelsberg TC, Riggs BL 1992 Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1β and tumor necrosis factor-α: Lack of regulation by 17β-estradiol. Endocrinology 130:2528-2534.
9. Birch MA, Ginty AF, Walsh CA, Fraser WD, Gallagher JA, Bilbe G 1993 PCR detection of cytokines in normal human and pagetic osteoblast-like cells. J Bone Miner Res 8:1155-1162.
10. Lisignoli G, Toneguzzi S, Pozzi C, Piacentini A, Riccio M, Ferruzzi A, Gualtieri G, Facchini A 1999 Proinflammatory cytokines and chemokine production and expression by human osteoblasts isolated from patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 26:791-799.
11. Kobayashi K, Kambe F, Kurokouchi K, Sakai T, Ishiguro N, Iwata H, Koga K, Gruener R, Seo H 2000 TNF-α-dependent activation of NF-κB in human osteoblastic HOS-TE85 cells is repressed in vector-averaged gravity using clinostat rotation. Biochem Biophys Res Commun 279:258-264.
12. Swarthout JT, D'Alonzo RC, Selvamurugan N, Partridge NC 2002 Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene 282:1-17.
13. Wali RK, Kong J, Sitrin MD, Bissonnette M, Li YC 2003 Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts. J Cell Biochem 88:794-801.
14. Danciu TE, Adam RM, Naruse K, Freeman MR, Hauschka PV 2003 Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett 536:193-197.
15. Okamoto S, Mukaida N, Yasumoto K, Rice N, Ishikawa Y, Horiguchi H, Murakami S, Matsushima K 1994 The interleukin-8 AP-1 and κB-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization. J Biol Chem 269:8582-8589.
16. 2+-dependent production and release of IL-8 in human neutrophils. J Immunol 161:4332-4339.
17. 2+ flux. Cell 83:463-472.
18. Klee CB, Ren H, Wang X 1998 Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 273:13367-13370.
19. Hemenway CS, Heitman J 1999 Calcineurin. Structure, function, and inhibition. Cell Biochem Biophys 30:115-151.
20. Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW 1995 Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature 378:641-644.
21. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA, de Chalain TM 1992 FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin: The effect of fuel source on amino acid metabolism in critically ill patients. Nature 357:692-694.
22. Rao A, Luo C, Hogan PG 1997 Transcription factors of the NFAT family: Regulation and function. Annu Rev Immunol 15:707-747.
23. Pincus T, Ferraccioli G, Sokka T, Larsen A, Rau R, Kushner I, Wolfe F 2002 Evidence from clinical trials and long-term observational studies that disease-modifying anti-rheumatic drugs slow radiographic progression in rheumatoid arthritis: Updating a 1983 review. Rheumatology 41:1346-1356.
24. Furst DE, Saag K, Fleischmann MR, Sherrer Y, Block JA, Schnitzer T, Rutstein J, Baldassare A, Kaine J, Calabrese L, Dietz F, Sack M, Senter RG, Wiesenhutter C, Schiff M, Stein CM, Satoi Y, Matsumoto A, Caldwell J, Harris RE, Moreland LW, Hurd E, Yocum D, Stamler DA 2002 Efficacy of tacrolimus in rheumatoid arthritis patients who have been treated unsuccessfully with methotrexate: A six-month, double-blind, randomized, dose-ranging study. Arthritis Rheum 46:2020-2028.
25. McAllister RM, Gardner MB, Greene AE, Bradt C, Nichols WW, Landing BH 1971 Cultivation in vitro of cells derived from a human osteosarcoma. Cancer 27:397-402.
26. Purohit A, Flanagan AM, Reed MJ 1992 Estrogen synthesis by osteoblast cell lines. Endocrinology 131:2027-2029.
27. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
28. Kambe F, Seo H, Murata Y, Matsui N 1988 Cloning of a cDNA coding for human thyroxine-binding globulin (TBG): Existence of two TBG mRNA species possessing different 3′-untranslated regions. Mol Endocrinol 2:181-185.
29. Sato M, Miyazaki T, Nagaya T, Murata Y, Ida N, Maeda K, Seo H 1996 Antioxidants inhibit tumor necrosis factor-α mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells. J Rheumatol 23:432-438.
30. Kambe F, Nomura Y, Okamoto T, Seo H 1996 Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells. Mol Endocrinol 10:801-812.
31. Kikumori T, Kambe F, Nagaya T, Imai T, Funahashi H, Seo H 1998 Activation of transcriptionally active nuclear factor-κB by tumor necrosis factor-α and its inhibition by antioxidants in rat thyroid FRTL-5 cells. Endocrinology 139:1715-1722.
32. Cao X, Kambe F, Miyazaki T, Sarkar D, Ohmori S, Seo H 2002 Novel human ZAKI-4 isoforms: Hormonal and tissue-specific regulation and function as calcineurin inhibitors. Biochem J 367:459-466.
33. Cao X, Kambe F, Ohmori S, Seo H 2002 Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8. Biochem Biophys Res Commun 297:288-293.
34. Liou HC, Baltimore D 1993 Regulation of the NF-κB/rel transcription factor and IκB inhibitor system. Curr Opin Cell Biol 5:477-487.
35. Kunsch C, Rosen CA 1993 NF-κB subunit-specific regulation of the interleukin-8 promoter. Mol Cell Biol 13:6137-6146.
36. Meyer S, Kohler NG, Joly A 1997 Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-κB activation. FEBS Lett 413:354-358.
37. Frantz B, Nordby EC, Bren G, Steffan N, Paya CV, Kincaid RL, Tocci MJ, O'Keefe SJ, O'Neill EA 1994 Calcineurin acts in synergy with PMA to inactivate I κB/MAD3, an inhibitor of NF-κB. EMBO J 13:861-870.
38. Trushin SA, Pennington KN, Algeciras-Schimnich A, Paya CV 1999 Protein kinase C and calcineurin synergize to activate IκB kinase and NF-κB in T lymphocytes. J Biol Chem 274:22923-22931.
39. Malinin NL, Boldin MP, Kovalenko AV, Wallach D 1997 MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385:540-544.
40. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB 1999 NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85.
41. Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M 2000 NAK is an IκB kinase-activating kinase. Nature 404:778-782.
42. Vertegaal AC, Kuiperij HB, Yamaoka S, Courtois G, van der Eb AJ, Zantema A 2000 Protein kinase C-α is an upstream activator of the IκB kinase complex in the TPA signal transduction pathway to NF-κB in U2OS cells. Cell Signal 12:759-768.
43. Saijo K, Mecklenbrauker I, Santana A, Leitger M, Schmedt C, Tarakhovsky A 2002 Protein kinase Cβ controls nuclear factor κB activation in B cells through selective regulation of the IκB kinase a. J Exp Med 195:1647-1652.
44. Tomita T, Takeuchi E, Tomita N, Morishita R, Kaneko M, Yamamoto K, Nakase T, Seki H, Kato K, Kaneda Y, Ochi T 1999 Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor κB decoy oligodeoxynucleotides as a gene therapy. Arthritis Rheum 42:2532-2542.