Influence of mass transfer limitations on the enzymatic synthesis of β-lactam antibiotics catalyzed by penicillin G acylase immobilized on glioxil-agarose

Bioprocess and Biosystems Engineering

Volumn 31, Issue 5, 2008, Pages 411-418

  Goncalves L R B ^a   Ferreira, A L O ^a   Fernandez Lafuente, R ^b   Guisan, J M ^b   Giordano, R C ^c   Giordano, R L C ^c  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b INSTITUTO DE CATÁLISIS Y PETROLEOQUÍMICA   (Spain)

^c FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

Amoxicillin; Ampicillin; Beta lactam antibiotics; Immobilized enzyme; Mass transfer effects; Penicillin G acylase

Indexed keywords

CONCENTRATION (PROCESS); DRUG PRODUCTS; ENZYME ACTIVITY; FOOD ADDITIVES; HEALTH; MASS TRANSFER; PH EFFECTS;

AGAROSE; AMOXICILLIN (A); CONCENTRATION PROFILES; DIFFUSIVE MODEL; EFFECTIVE DIFFUSIVITIES; ENZYMATIC SYNTHESES; ENZYME LOADS; FILM RESISTANCE; INTRA-PARTICLE DIFFUSION; MASS TRANSFER EFFECTS; MASS TRANSFER LIMITATIONS; MEAN PORE DIAMETERS; PARTICLE MASSES; PENICILLIN G ACYLASE (PGA); PORE DIAMETERS; STIRRING RATES;

ENZYMES;

AGAROSE; AMOXICILLIN; AMPICILLIN; BETA LACTAM ANTIBIOTIC; PENICILLIN AMIDASE;

ARTICLE; BIOCATALYST; ENZYME ACTIVITY; ENZYME SYNTHESIS; PRIORITY JOURNAL;

AMOXICILLIN; AMPICILLIN; BETA-LACTAMS; CATALYSIS; COMPUTER SIMULATION; ENZYMES, IMMOBILIZED; MEMBRANES, ARTIFICIAL; MODELS, CHEMICAL; PENICILLIN AMIDASE; SEPHAROSE;

EID: 47349125873     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-007-0176-2     Document Type: Article

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