A simplified kinetic model for the side reactions occurring during the enzymatic synthesis of ampicillin

Brazilian Journal of Chemical Engineering

Volumn 17, Issue 4, 2000, Pages 835-839

  Ferreira, A L O ^a   Goncalves L R B ^a,b   Giordano, R C ^a   Giordano, R L C ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Ampicillin hydrolysis; Immobilized enzyme; Kinetic model; Penicillin G acylase

Indexed keywords

EID: 0346976397     PISSN: 01046632     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0104-66322000000400046     Document Type: Article

References (7)

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2. Ferreira, A. L. O.; Gonçalves, L. R. B.; Giordano, R. L. C. and Giordano, R. C. (1999), Efeitos Difusivos na Síntese de Ampicilina Catalisada por Penicilina G Acilase Imobilizada, Anais do XXVII ENEMP, Campos de Jordão (in press).
3. Gonçalves, L.R.B.; Fernadez-Lafuente, R.; Guisán, J.M. and Giordano, R.L.C. (2000), A kinetic study of the synthesis of amoxicillin using penicillin G acylase immobilized on agarose, Applied Biochemistry and Biotechnology, vol. 84-86 (in press).
4. Hou, J. P. and Poole, J. W. (1969), the amino acid nature of ampicillin and related penicillins, Journal of Pharmaceutical Sciences, vol. 58, no 12, 1510-1515.
5. Kaasgaard, S.G. and Veitland; U. (1996), Process for preparation of beta.-lactams utilizing a combined concentration of acylating agent plus.beta.-lactam derivative of at least 400 mm, US Patent 5,525,483; USA.
6. Marquardt, D. W. (1963), An algorithm for least-squares estimation of nonlinear parameters, J. Soc. Ind. Appl. Math., 11, 431-41.
7. Ospina, S.; Barzana, E.; Ramírez, O.T. and López-Munguía, A. (1996), Effect of pH in the Synthesis of Ampicillin by Penicillin Amidase, Enzyme and Microbial Technology, 19, 462-469.