Structural properties of the human respiratory syncytial virus P protein: Evidence for an elongated homotetrameric molecule that is the smallest orthologue within the family of paramyxovirus polymerase cofactors

Proteins: Structure, Function and Genetics

Volumn 72, Issue 3, 2008, Pages 946-958

  Llorente, María T ^a,b   Taylor, Ian A ^c   López Viñas, Eduardo ^d,e   Gomez Puertas, Paulino ^d,e   Calder, Lesley J ^c   García Barreno, Blanca ^a,b   Melero, José A ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

3 D modeling; Paramyxovirus polymerase cofactors; Phosphoprotein hydrodynamics and oligomerization; Respiratory syncytial virus; Thermal denaturation

Indexed keywords

CHYMOTRYPSIN; OLIGOMER; PHOSPHOPROTEIN; TRYPSIN; VIRUS ENZYME; VIRUS PROTEIN;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DENATURATION; ELECTRON MICROSCOPY; GEL FILTRATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDRODYNAMICS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SEDIMENTATION RATE; SENDAI VIRUS; STRUCTURE ANALYSIS; ULTRACENTRIFUGATION;

AMINO ACID SEQUENCE; CHYMOTRYPSIN; CIRCULAR DICHROISM; COENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN DENATURATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RNA REPLICASE; SEQUENCE HOMOLOGY, AMINO ACID; TEMPERATURE; THERMODYNAMICS; TRYPSIN; VIRAL STRUCTURAL PROTEINS;

HUMAN RESPIRATORY SYNCYTIAL VIRUS; HYDRANGEA RINGSPOT VIRUS; PARAMYXOVIRIDAE; RESPIRATORY SYNCYTIAL VIRUS; SENDAI VIRUS;

EID: 47349091097     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21988     Document Type: Article

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