A role for the Sendai virus P protein trimer in RNA synthesis

Journal of Virology

Volumn 72, Issue 5, 1998, Pages 4274-4280

  Curran, Joseph ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN RNA BINDING; RNA SYNTHESIS; SENDAI VIRUS; VIRUS NUCLEOCAPSID;

EID: 0031968675     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.5.4274-4280.1998     Document Type: Article

References (36)

1. Buchholz, C. J., C. Retzler, E. Horst, H. E. Homann, and W. J. Neubert. 1994. The carboxy-terminal domain of Sendai virus nucleocapsid protein is involved in complex formation between the phosphoprotein and nucleocapsid like particles. Virology 204:770-776.
2. Cadd, T., D. Garcin, C. Tapparel, M. Itoh, M. Homma, L. Roux, J. Curran, and D. Kolakofsky. 1996. The Sendai paramyxovirus accessory C proteins inhibit viral genome amplification in a promoter-specific fashion. J. Virol. 70:5067-5074.
3. Curran, J. 1996. Reexamination of the Sendai virus P protein domains required for RNA synthesis. A possible supplemental role for the P protein. Virology 221:130-140.
4. Curran, J., R. Boeck, and D. Kolakofsky. 1991. The Sendai virus P gene expresses both an essential protein and an inhibitor of RNA synthesis by shuffling modules via mRNA editing. EMBO J. 10:3079-3085.
5. Curran, J., H. Homann, C. Buchholz, S. Rochat, W. Neubert, and D. Kolakofsky. 1993. The hypervariable C-terminal tail of the Sendai paramyxovirus nucleocapsid protein is required for template function but not for RNA encapsidation. J. Virol. 67:4358-4364.
6. Curran, J., J.-B. Marq, and D. Kolakofsky. 1992. The Sendai virus nonstructural C proteins specifically inhibit viral mRNA synthesis. Virology 189:647-656.
7. Curran, J., J.-B. Marq, and D. Kolakofsky. 1995. An N-terminal domain of the Sendai paramyxovirus P protein acts as a chaperone for the NP protein during the nascent chain assembly step of genome replication. J. Virol. 69:849-855.
8. Curran, J., T. Pelet, and D. Kolakofsky. 1994. An acidic activation-like domain of the Sendai virus P protein is required for RNA synthesis and encapsidation. Virology 202:875-884.
9. Curran, J., R. Boeck, N. Lin-Marq, A. Lupas, and D. Kolakofsky. 1995. Paramyxovirus phosphoproteins form homo-trimers as determined by an epitope dilution assay, via predicted coiled coils. Virology 214:139-149.
10. Egelman, E. H., S. S. Wu, M. Amrein, A. Portner, and K. Murti. 1989. The Sendai virus nucleocapsid exists in at least four different helical states. J. Virol. 63:2233-2243.
11. Einberger, H., P. H. Mertz, P. H. Hofschneider, and W. J. Neubert. 1990. Purification, renaturation, and reconstituted protein kinase activity of the Sendai virus large (L) protein: L protein phosphorylates the NP and P proteins in vitro. J. Virol. 64:4274-4280.
12. Field, J., J.-I. Nikawa, D. Broeck, B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159-2165.
13. Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122-3126.
14. Gao, Y., N. J. Greenfield, D. Z. Cleverley, and J. Lenard. 1996. The transcriptional form of the phosphoprotein of vesicular stomatitis virus is a trimer: structure and stability. Biochemistry 35:14569-14573.
15. Gao, Y., and J. Lenard. 1995. Multimerization and transcriptional activation of the phosphoprotein (P) of vesicular stomatitis virus by casein kinase-II. EMBO J. 14:1240-1247.
16. Gao, Y., and J. Lenard. 1995. Cooperative binding of multimeric phosphoprotein (P) of vesicular stomatitis virus to polymerase (L) and template: pathways of assembly. J. Virol. 69:7718-7723.
17. Hamagushi, M., T. Yoshida, K. Nishikawa, H. Naruse, and Y. Nagai. 1983. Transcriptive complex of Newcastle disease virus. I. Both L and P proteins are required to constitute an active complex. Virology 128:105-117.
18. Heggeness, M. H., A. Scheid, and P. W. Choppin. 1981. The relationship of conformational changes in the Sendai virus nucleocapsid to proteolytic cleavage of the NP polypeptide. Virology 114:555-562.
19. Horikami, S. M., J. Curran, D. Kolakofsky, and S. A. Moyer. 1992. Complexes of Sendai virus NP-P and P-L proteins are required for defective interfering genome replication in vitro. J. Virol. 66:4901-4908.
20. Horikami, S. M., R. E. Hector, S. Smallwood, and S. A. Moyer. 1997. The Sendai virus C protein binds L polymerase protein to inhibit viral RNA synthesis. Virology 235:261-270.
21. Horikami, S. M., and S. A. Moyer. 1995. Alternative amino acids at a single site in the Sendai virus L protein produce multiple defects in RNA synthesis in vitro. Virology 211:577-582.
22. Hudson, L. D., C. Condra, and R. A. Lazzarini. 1986. Cloning and expression of a viral phosphoprotein: structure suggests vesicular stomatitis virus NS may function by mimicking an RNA template. J. Gen. Virol. 67:1571-1579.
23. Kolakofsky, D., J. Curran, T. Pelet, and J.-P. Jacques. 1993. Paramyxovirus P gene mRNA editing, p. 105-123. In R. Benne (ed.), RNA editing. Ellis Horwood, Chichester, England.
24. Lamb, R. A., and D. Kolakofsky. 1996. Paramyxoviridae: the viruses and their application, p. 1177-1204. In B. N. Fields et al. (ed.), Fields virology. Raven Press, New York, N.Y.
25. Lamb, R. A., B. W. Mahy, and P. W. Choppin. 1976. The synthesis of Sendai virus polypeptides in infected cells. Virology 69:116-131.
26. Latorre, P., D. Kolakofsky, and J. Curran. The Sendai virus Y proteins are initiated by a ribosomal shunt. Submitted for publication.
27. Mellon, M. G., and S. U. Emerson. 1978. Rebinding of transcriptase components (L and NS) proteins to the nucleocapsid template of vesicular stomatitis virus. J. Virol. 27:560-567.
28. Mountcastle, W. E., R. W. Compans, H. Lackland, and P. W. Choppin. 1974. Proteolytic cleavage of subunits of the nucleocapsid of the paramyxovirus simian virus 5. J. Virol. 14:1253-1261.
29. Orvell, C., and M. Grandien. I982. The effects of monoclonal antibodies on biologic activities of structural proteins of Sendai virus. J. Immunol. 129: 2779-2787.
30. Pelet, T., J.-B. Marq, Y. Sakai, S. Wakao, H. Gotoh, and J. Curran. 1996. Rescue of Sendai virus cDNA templates with cDNA clones expressing parainfluenza virus type 3 N, P and L clones. J. Gen. Virol. 77:2465-2469.
31. Portner, A., K. G. Murti, E. M. Morgan, and D. W. Kingsbury. 1988. Antibodies against Sendai virus L protein: distribution of the protein in nucleocapsids revealed by immunoelectron microscopy. Virology 163:236-239.
32. Ryan, K. W., E. M. Morgan, and A. Portner. 1991. Two noncontiguous regions of Sendai virus P protein combine to form a single nucleocapsid binding domain. Virology 180:126-134.
33. Simonet, V., and J. Curran. The NDV P protein forms a stable homotrimer and oligomerization appears necessary for template binding. Submitted for publication.
34. Smallwood, S., K. W. Ryan, and S. A. Moyer. 1994. Deletion analysis defines a carboxy-proximal region of the Sendai virus P protein that binds to the polymerase L protein. Virology 202:154-163.
35. Spadafora, D., D. M. Canter, R. L. Jackson, and J. Perrault. 1996. Constitutive phosphorylation of the vesicular stomatitis virus P protein modulates complex formation but is not essential for transcription or replication. J. Virol. 70:4538-4548.
36. Tapparel, C., S. Hausmann, T. Pelet, J. Curran, D. Kolakofsky, and L. Roux. 1997. Inhibition of Sendai virus genome replication due to promoter-increased selectivity: a possible role for the accessory C proteins. J. Virol. 71:9588-9599.