Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice

Clinical and Experimental Medicine

Volumn 8, Issue 2, 2008, Pages 93-99

  Arai, T ^a   Hashimoto, H ^b   Kawai, K ^b   Mori, A ^a   Ohnishi, Y ^b   Hioki, K ^b   Ito, M ^b   Saito, M ^b   Ueyama, Y ^c   Ohsugi, M ^c   Suzuki, R ^d   Kubota, N ^d   Yamauchi, T ^d   Tobe, K ^d   Kadowaki, T ^d   Kosaka, K ^d  

^a NIPPON VETERINARY AND LIFE SCIENCE UNIVERSITY   (Japan)

^b CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Insulin; IRS2 knockout mouse; Ketone body; Liver; Type 1 diabetes mellitus

Indexed keywords

C PEPTIDE; IMMUNOREACTIVE INSULIN; INSULIN RECEPTOR SUBSTRATE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KETONURIA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; DIABETES MELLITUS, TYPE 1; FATTY ACIDS, NONESTERIFIED; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; PHOSPHOPROTEINS; TRIGLYCERIDES;

ANIMALIA; MUS;

EID: 47349085097     PISSN: 15918890     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10238-008-0163-1     Document Type: Article

References (40)

1. Tamemoto H, Kadowaki K, Tobe K et al (1994) Insulin resistance and growth in mice lacking insulin receptor substrate-1. Nature 372:182-186
2. Araki E, Lipes MA, Patti ME et al (1994) Alternative pathway of insulin signaling in mice with target disruption of the IRS-1 gene. Nature 372:186-190
3. Suzuki R, Tobe K, Aoyama M et al (2004) Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice. J Biol Chem 279:25039-25049
4. Patti ME, Sun XJ, Bruening JC et al (1995) 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem 270:24670-24673
5. Terauchi Y, Iwamoto K, Tamemoto H et al (1997) Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase gene. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest 99:861-866
6. Withers DJ, Burks DJ, Towery H et al (1999) Irs-2 cooperated Igf-1 receptor-mediated beta-cell development and peripheral insulin signaling. Nat Med 23:32-40
7. Kido Y, Burks DJ, Withers DJ et al (2000) Tissue-specific insulin resistance in mice with mutations in the insulin receptors, IRS-1, and IRS-2. J Clin Invest 105:199-205
8. Kubota N, Tobe K, Terauchi Y et al (2000) Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 49:1880-1889
9. Hashimoto H, Arai T, Takeguchi A et al (2006) Ontogenic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2. Comp Med 56:176-187
10. Imagawa A, Hanafusa T, Miyagawa J et al (2000) A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. N Engl J Med 342:301-307
11. Imagawa A, Hanafusa T, Miyagawa J et al (2000) A proposal of three distinct subtypes of type 1 diabetes mellitus based on clinical and pathological evidence. Ann Med 32:539-543
12. Imagawa A, Hanafusa T (2006) Fulminant type 1 diabetes mellitus. Endocr J 53:577-584
13. Tsuji A, Torres-Rosado A, Arai T et al (1991) Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization. J Biol Chem 266:16948-16953
14. Huggett AG, Nixon DA (1957) Use of glucose oxidase, peroxidase and o-dianisidine in determination of blood and urinary glucose. Lancet 2:368-370
15. Tanaka A, Urabe S, Takeguchi A et al (2006) Comparison of activities of enzymes related to energy metabolism in peripheral leukocytes and livers between Holstein dairy cows and ICR mice. Vet Res Commun 30:29-38
16. Vinuela E, Salas M, Sols A (1963) Glucokinase and hexokinase in liver in relation to glycogen synthesis. J Biol Chem 238:PC1175-PC1177
17. Bergmeyer HU, Gawehn K, Grassl M (1974) Glucose-6-phosphate dehydrogenase from yeast. In: Bergmeyer HU (ed) Methods of enzymatic analysis, Vol 1. Verlag Chemie, New York, pp 458-459
18. Kaloustian HD, Stolzenbach FE, Everse J et al (1969) Lactate dehydrogenase of lobster (Hornarus americanus) tail muscle. I. Physical and chemical properties. J Biol Chem 244:2891-2901
19. Bergmeyer HU, Bernt E (1974) Malate dehydrogenase. UV-assay. In: Bergmeyer HU (ed) Methods of enzymatic analysis, Vol 2. Verlag Chemie, New York, pp 613-617
20. Rej R, Horder M (1983) Aspartate aminotransferase (glutamate oxaloacetate transaminase). In: Bergmeyer HU (ed) Methods of enzymatic analysis, 3rd Edn. Verlag Chemie, New York, pp 416-433
21. Jomain-Baum M, Schramm VL, Hanson RW (251) Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP). J Biol Chem 251:37-44
22. Latzko E, Gibbs M (1974) Alkaline C1-fructose-1,6-diphosphatase. In: Bergmeyer HU (ed) Methods of enzymatic analysis, Vol 2. Verlag Chemie, New York, pp 881-884
23. Takeda Y, Suzuki F, Inoue H (1969) ATP citrate lyase (citrate cleavage enzyme). In: Lowenstein JM (ed) Methods of enzymology, Vol 13. Academic Press, New York, pp 153-160
24. Martin BB, Denton RM (1970) The intracellular localization of enzymes in white-adipose-tissue fat cells and permeability properties of fat-cell mitochondria. Biochem J 117:861-877
25. Halestrap AP, Denton RM (1973) Insulin and the regulation of adipose tissue acetyl-coenzyme A carboxylase. Biochem J 132:509-517
26. Schmidt E (1974) Glutamate dehydrogenase UV-assay. In: Bergmeyer HU (ed) Methods of enzymatic analysis, Vol 2. Verlag Chemie, New York, pp 650-656
27. Bergmeyer HU, Gawehn K, Grassl M (1974) 3-Hydroxybutyrate dehydrogenase. In: Bergmeyer HU (ed) Methods of enzymatic analysis, Vol 1. Verlag Chemie, New York, pp 475-476
28. Scrutton MC, Olmsted MR, Utter MF (1969) Pyruvate carboxylase from chicken liver. In: Lowenstein JM (ed) Methods in enzymology, Vol 13. Academic Press, New York, pp 235-250
29. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
30. Imagawa A, Hanafusa T, Uchigata Y et al (2003) Fulminant type 1 diabetes. a nationwide survey in Japan. Diabetes Care 26:2345-2352
31. Sayama K, Imagawa A, Okita K et al (2005) Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment. Diabetologia 48:1560-1564
32. Imagawa A, Hanafusa T, Uchigata Y et al (2005) Different contribution of class II HLA in fulminant and typical autoimmune type 1 diabetes mellitus. Diabetologia 48:294-300
33. Michael MD, Kulkarni RN, Postic C et al (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6:87-97
34. Newsholme P, Gordon S, Newsholme EA (1987) Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. Biochem J 242:631-636
35. Otton R, Mendonca JR, Curi R (2002) Diabetes causes marked changes in lymphocyte metabolism. J Endocrinol 174:55-61
36. MacDonald MJ (1982) Evidence of the malate aspartate shuttle in pancreatic islet. Arch Biochem Biophys 213:643-649
37. Matschinsky FM (1996) A lesson in metabolic regulation inspired by the glucokinase sensor paradigm. Diabetes 45:223-241
38. Magori E, Nakamura M, Inoue A et al (2005) Malate dehydrogenase activities are lower in some types of peripheral leucocytes of dogs and cats with type 1 diabetes mellitus. Res Vet Sci 78:39-44
39. -/- mouse liver. J Biol Chem 276:38337-38340
40. Taniguchi CM, Ueki K, Kahn CR (2005) Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 115:718-727