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Volumn 36, Issue 12, 2008, Pages 4047-4056

Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA; KU ANTIGEN; METHYLNITROSOUREA; PROTEIN MSH6;

EID: 47249164855     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn341     Document Type: Article
Times cited : (16)

References (44)
  • 1
    • 0033858522 scopus 로고    scopus 로고
    • The mutagenic action of N-ethyl-N-nitrosourea in the mouse
    • Noveroske,J.K., Weber,J.S. and Justice,M.J. (2000) The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm. Genome, 11, 478-483.
    • (2000) Mamm. Genome , vol.11 , pp. 478-483
    • Noveroske, J.K.1    Weber, J.S.2    Justice, M.J.3
  • 2
    • 33845726097 scopus 로고    scopus 로고
    • Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks
    • Wyatt,M.D. and Pittman,D.L. (2006) Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chem. Res. Toxicol., 19, 1580-1594.
    • (2006) Chem. Res. Toxicol , vol.19 , pp. 1580-1594
    • Wyatt, M.D.1    Pittman, D.L.2
  • 3
    • 33845935791 scopus 로고    scopus 로고
    • The structural basis for the mutagenicity of O(6)-methyl-guanine lesions
    • Warren,J.J., Forsberg,L.J. and Beese,L.S. (2006) The structural basis for the mutagenicity of O(6)-methyl-guanine lesions. Proc. Natl Acad. Sci. USA, 103, 19701-19706.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 19701-19706
    • Warren, J.J.1    Forsberg, L.J.2    Beese, L.S.3
  • 4
    • 0034027358 scopus 로고    scopus 로고
    • Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents
    • Bignami,M., O'Driscoll,M., Aquilina,G. and Karran,P. (2000) Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents. Mutat. Res., 462, 71-82.
    • (2000) Mutat. Res , vol.462 , pp. 71-82
    • Bignami, M.1    O'Driscoll, M.2    Aquilina, G.3    Karran, P.4
  • 5
    • 0027340278 scopus 로고
    • Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines
    • Kaina,B., Fritz,G. and Coquerelle,T. (1993) Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines. Environ. Mol. Mutagen., 22, 283-292.
    • (1993) Environ. Mol. Mutagen , vol.22 , pp. 283-292
    • Kaina, B.1    Fritz, G.2    Coquerelle, T.3
  • 6
    • 0028177755 scopus 로고
    • Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyltransferases
    • Zak,P., Kleibl,K. and Laval,F. (1994) Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyltransferases. J. Biol. Chem., 269, 730-733.
    • (1994) J. Biol. Chem , vol.269 , pp. 730-733
    • Zak, P.1    Kleibl, K.2    Laval, F.3
  • 7
    • 0032851842 scopus 로고    scopus 로고
    • Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
    • Hickman,M.J. and Samson,L.D. (1999) Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents. Proc. Natl Acad. Sci. USA, 96, 10764-10769.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 10764-10769
    • Hickman, M.J.1    Samson, L.D.2
  • 8
    • 33645322935 scopus 로고    scopus 로고
    • Signalling cell cycle arrest and cell death through the MMR System
    • O'Brien,V. and Brown,R. (2006) Signalling cell cycle arrest and cell death through the MMR System. Carcinogenesis, 27, 682-692.
    • (2006) Carcinogenesis , vol.27 , pp. 682-692
    • O'Brien, V.1    Brown, R.2
  • 9
    • 3242885728 scopus 로고    scopus 로고
    • Mismatch repair and DNA damage signalling
    • Stojic,L., Brun,R. and Jiricny,J. (2004) Mismatch repair and DNA damage signalling. DNA Repair, 3, 1091-1101.
    • (2004) DNA Repair , vol.3 , pp. 1091-1101
    • Stojic, L.1    Brun, R.2    Jiricny, J.3
  • 10
    • 33646187811 scopus 로고    scopus 로고
    • The multifaceted mismatch-repair system
    • Jiricny,J. (2006) The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell. Biol., 7, 335-346.
    • (2006) Nat. Rev. Mol. Cell. Biol , vol.7 , pp. 335-346
    • Jiricny, J.1
  • 11
    • 0347364654 scopus 로고    scopus 로고
    • MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
    • Wang,Y. and Qin,J. (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl Acad. Sci. USA, 100, 15387-15392.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15387-15392
    • Wang, Y.1    Qin, J.2
  • 12
    • 33646503204 scopus 로고    scopus 로고
    • ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
    • Yoshioka,K., Yoshioka,Y. and Hsieh,P. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell, 22, 501-510.
    • (2006) Mol. Cell , vol.22 , pp. 501-510
    • Yoshioka, K.1    Yoshioka, Y.2    Hsieh, P.3
  • 13
    • 2442670292 scopus 로고    scopus 로고
    • Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
    • Stojic,L., Mojas,N., Cejka,P., Di Pietro,M., Ferrari,S., Marra,G. and Jiricny,J. (2004) Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes Dev., 18, 1331-1344.
    • (2004) Genes Dev , vol.18 , pp. 1331-1344
    • Stojic, L.1    Mojas, N.2    Cejka, P.3    Di Pietro, M.4    Ferrari, S.5    Marra, G.6    Jiricny, J.7
  • 14
    • 1542358851 scopus 로고    scopus 로고
    • Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations
    • Debiak,M., Nikolova,J. and Kaina,B. (2004) Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations. DNA Repair, 3, 359-368.
    • (2004) DNA Repair , vol.3 , pp. 359-368
    • Debiak, M.1    Nikolova, J.2    Kaina, B.3
  • 15
    • 36549076065 scopus 로고    scopus 로고
    • DNA mismatch repair-induced double-strand breaks
    • Nowosielska,A. and Marinus,M.G. (2008) DNA mismatch repair-induced double-strand breaks. DNA Repair, 7, 48-56.
    • (2008) DNA Repair , vol.7 , pp. 48-56
    • Nowosielska, A.1    Marinus, M.G.2
  • 16
    • 37249019677 scopus 로고    scopus 로고
    • Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA
    • Mojas,N., Lopes,M. and Jiricny,J. (2007) Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA. Genes Dev., 21 3342-3355.
    • (2007) Genes Dev , vol.21 , pp. 3342-3355
    • Mojas, N.1    Lopes, M.2    Jiricny, J.3
  • 17
  • 18
    • 0033857841 scopus 로고    scopus 로고
    • Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts
    • Zhang,H., Marra,G., Jiricny,J., Maher,V.M. and McCormick,J.J. (2000) Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts. Carcinogenesis, 21, 1639-1646.
    • (2000) Carcinogenesis , vol.21 , pp. 1639-1646
    • Zhang, H.1    Marra, G.2    Jiricny, J.3    Maher, V.M.4    McCormick, J.J.5
  • 19
    • 23244437745 scopus 로고    scopus 로고
    • Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae
    • Cejka,P., Mojas,N., Gillet,L., Schar,P. and Jiricny,J. (2005) Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Curr. Biol., 15 1395-1400.
    • (2005) Curr. Biol , vol.15 , pp. 1395-1400
    • Cejka, P.1    Mojas, N.2    Gillet, L.3    Schar, P.4    Jiricny, J.5
  • 20
    • 19444383617 scopus 로고    scopus 로고
    • Spontaneous and mutagen-induced loss of DNA mismatch repair in Msh2-heterozygous mammalian cells
    • Borgdorff,V., van Hees-Stuivenberg,S., Meijers,C.M. and de Wind,N. (2005) Spontaneous and mutagen-induced loss of DNA mismatch repair in Msh2-heterozygous mammalian cells. Mutat. Res., 574, 50-57.
    • (2005) Mutat. Res , vol.574 , pp. 50-57
    • Borgdorff, V.1    van Hees-Stuivenberg, S.2    Meijers, C.M.3    de Wind, N.4
  • 21
    • 0038405046 scopus 로고    scopus 로고
    • DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis
    • Claij,N., van der Wal,A., Dekker,M., Jansen,L. and te Riele,H. (2003) DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis. Cancer Res., 63, 2062-2066.
    • (2003) Cancer Res , vol.63 , pp. 2062-2066
    • Claij, N.1    van der2    Wal, A.3    Dekker, M.4    Jansen, L.5    te Riele, H.6
  • 22
    • 0030709304 scopus 로고    scopus 로고
    • Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents
    • Armstrong,M.J. and Galloway,S.M. (1997) Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents. Mutat. Res., 373, 167-178.
    • (1997) Mutat. Res , vol.373 , pp. 167-178
    • Armstrong, M.J.1    Galloway, S.M.2
  • 23
    • 0028987786 scopus 로고
    • A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells
    • Galloway,S.M., Greenwood,S.K., Hill,R.B., Bradt,C.I. and Bean,C.L. (1995) A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells. Mutat. Res., 346, 231-245.
    • (1995) Mutat. Res , vol.346 , pp. 231-245
    • Galloway, S.M.1    Greenwood, S.K.2    Hill, R.B.3    Bradt, C.I.4    Bean, C.L.5
  • 24
    • 0028387996 scopus 로고
    • Large-scale mutagenesis in the zebrafish: In search of genes controlling development in a vertebrate
    • Mullins,M.C., Hammerschmidt,M., Haffter,P. and Nusslein-Volhard,C. (1994) Large-scale mutagenesis in the zebrafish: In search of genes controlling development in a vertebrate. Curr. Biol., 4, 189-202.
    • (1994) Curr. Biol , vol.4 , pp. 189-202
    • Mullins, M.C.1    Hammerschmidt, M.2    Haffter, P.3    Nusslein-Volhard, C.4
  • 25
    • 0028270120 scopus 로고
    • Efficient recovery of ENU-induced mutations from the zebrafish germline
    • Solnica-Krezel,L., Schier,A.F. and Driever,W. (1994) Efficient recovery of ENU-induced mutations from the zebrafish germline. Genetics, 136, 1401-1420.
    • (1994) Genetics , vol.136 , pp. 1401-1420
    • Solnica-Krezel, L.1    Schier, A.F.2    Driever, W.3
  • 26
    • 16644396292 scopus 로고    scopus 로고
    • Target-selected gene inactivation in zebrafish
    • Wienholds,E. and Plasterk,R.H. (2004) Target-selected gene inactivation in zebrafish. Methods Cell. Biol., 77, 69-90.
    • (2004) Methods Cell. Biol , vol.77 , pp. 69-90
    • Wienholds, E.1    Plasterk, R.H.2
  • 27
    • 0347382439 scopus 로고    scopus 로고
    • Wienholds,E., van Eeden,F., Kosters.M., Mudde,J., Plasterk,R.H. and Cuppen,E. (2003) Efficient target-selected mutagenesis in zebrafish. Genome Res., 13, 2700-2707.
    • Wienholds,E., van Eeden,F., Kosters.M., Mudde,J., Plasterk,R.H. and Cuppen,E. (2003) Efficient target-selected mutagenesis in zebrafish. Genome Res., 13, 2700-2707.
  • 28
    • 48549088063 scopus 로고    scopus 로고
    • Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors
    • in press
    • Feitsma,H., Kuiper,R.V., Korving,J., Nijman,I.J. and Cupper,E. Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors. Cancer Res., in press.
    • Cancer Res
    • Feitsma, H.1    Kuiper, R.V.2    Korving, J.3    Nijman, I.J.4    Cupper, E.5
  • 31
    • 0027386243 scopus 로고
    • The zebrafish midblastula transition
    • Kane,D.A. and Kimmel,C.B. (1993) The zebrafish midblastula transition. Development, 119, 447-456.
    • (1993) Development , vol.119 , pp. 447-456
    • Kane, D.A.1    Kimmel, C.B.2
  • 32
    • 0024505212 scopus 로고
    • Clonal origins of cells in the pigmented retina of the zebrafish eye
    • Streisinger,G., Coale,F., Taggart,C., Walker,C. and Grunwald,D.J. (1989) Clonal origins of cells in the pigmented retina of the zebrafish eye. Dev. Biol., 131, 60-69.
    • (1989) Dev. Biol , vol.131 , pp. 60-69
    • Streisinger, G.1    Coale, F.2    Taggart, C.3    Walker, C.4    Grunwald, D.J.5
  • 33
    • 0031318025 scopus 로고    scopus 로고
    • Regional cell movement and tissue patterning in the zebrafish embryo revealed by fate mapping with caged fluorescein
    • Kozlowski,D.J., Murakami,T., Ho,R.K. and Weinberg,E.S. (1997) Regional cell movement and tissue patterning in the zebrafish embryo revealed by fate mapping with caged fluorescein. Biochem. Cell. Biol., 75 551-562.
    • (1997) Biochem. Cell. Biol , vol.75 , pp. 551-562
    • Kozlowski, D.J.1    Murakami, T.2    Ho, R.K.3    Weinberg, E.S.4
  • 34
    • 20144386307 scopus 로고    scopus 로고
    • DNA damage response and Ku80 function in the vertebrate embryo
    • Bladen,C.L., Lam,W.K., Dynan,W.S. and Kozlowski,D.J. (2005) DNA damage response and Ku80 function in the vertebrate embryo. Nucleic Acids Res., 33, 3002-3010.
    • (2005) Nucleic Acids Res , vol.33 , pp. 3002-3010
    • Bladen, C.L.1    Lam, W.K.2    Dynan, W.S.3    Kozlowski, D.J.4
  • 35
    • 34447509272 scopus 로고    scopus 로고
    • Expression of the Ku70 subunit (XRCC6) and protection from low dose ionizing radiation during zebrafish embryogenesis
    • Bladen,C.L., Navarre,S., Dynan,W.S. and Kozlowski,D.J. (2007) Expression of the Ku70 subunit (XRCC6) and protection from low dose ionizing radiation during zebrafish embryogenesis. Neurosci. Lett., 422 97-102.
    • (2007) Neurosci. Lett , vol.422 , pp. 97-102
    • Bladen, C.L.1    Navarre, S.2    Dynan, W.S.3    Kozlowski, D.J.4
  • 37
    • 20444362414 scopus 로고    scopus 로고
    • Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans
    • Denver,D.R., Feinberg,S., Estes,S., Thomas,W.K. and Lynch,M. (2005) Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Genetics, 170, 107-113.
    • (2005) Genetics , vol.170 , pp. 107-113
    • Denver, D.R.1    Feinberg, S.2    Estes, S.3    Thomas, W.K.4    Lynch, M.5
  • 38
    • 0035989395 scopus 로고    scopus 로고
    • Frequent germ-line mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans
    • Tijsterman,M., Pothof,J. and Plasterk,R.H. (2002) Frequent germ-line mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Genetics, 161 651-660.
    • (2002) Genetics , vol.161 , pp. 651-660
    • Tijsterman, M.1    Pothof, J.2    Plasterk, R.H.3
  • 39
    • 34547549214 scopus 로고    scopus 로고
    • Epigenetic therapy in cancer: Molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors
    • Schneider-Stock,R. and Ocker,M. (2007) Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors. IDrugs, 10, 557-561.
    • (2007) IDrugs , vol.10 , pp. 557-561
    • Schneider-Stock, R.1    Ocker, M.2
  • 40
    • 0021063154 scopus 로고
    • X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents
    • Jeggo,P.A. and Kemp,L.M. (1983) X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents. Mutat. Res., 112, 313-327.
    • (1983) Mutat. Res , vol.112 , pp. 313-327
    • Jeggo, P.A.1    Kemp, L.M.2
  • 41
    • 0033562777 scopus 로고    scopus 로고
    • Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo
    • Ikegami,R., Hunter,P. and Yager,T.D. (1999) Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo. Dev. Biol., 209, 409-433.
    • (1999) Dev. Biol , vol.209 , pp. 409-433
    • Ikegami, R.1    Hunter, P.2    Yager, T.D.3
  • 42
    • 0029039818 scopus 로고
    • Efficient induction of point mutations allowing recovery of specific locus mutations in zebrafish
    • Riley,B.B. and Grunwald,D.J. (1995) Efficient induction of point mutations allowing recovery of specific locus mutations in zebrafish. Proc. Natl Acad. Sci. USA, 92, 5997-6001.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 5997-6001
    • Riley, B.B.1    Grunwald, D.J.2
  • 43
    • 0034017136 scopus 로고    scopus 로고
    • Analysis of chromosomal rearrangements induced by postmeiotic mutagenesis with ethylnitrosourea in zebrafish
    • Imai,Y., Feldman,B., Schier,A.F. and Talbot,W.S. (2000) Analysis of chromosomal rearrangements induced by postmeiotic mutagenesis with ethylnitrosourea in zebrafish. Genetics, 155, 261-272.
    • (2000) Genetics , vol.155 , pp. 261-272
    • Imai, Y.1    Feldman, B.2    Schier, A.F.3    Talbot, W.S.4
  • 44
    • 33846690097 scopus 로고    scopus 로고
    • Comparison of the genetic effects of equimolar doses of ENU and MNU: While the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia
    • Russell,L.B., Hunsicker,P.R. and Russell,W.L. (2007) Comparison of the genetic effects of equimolar doses of ENU and MNU: While the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia. Mutat. Res., 616, 181-195.
    • (2007) Mutat. Res , vol.616 , pp. 181-195
    • Russell, L.B.1    Hunsicker, P.R.2    Russell, W.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.