Role of ephrinB2 expression in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment

Blood

Volumn 112, Issue 1, 2008, Pages 73-81

  Korff, Thomas ^a   Braun, Jennifer ^a   Pfaff, Dennis ^b   Augustin, Hellmut G ^b   Hecker, Markus ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN B2; MONOCYTE CHEMOTACTIC PROTEIN 1; CCL2 PROTEIN, HUMAN; MESSENGER RNA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; HEMODYNAMICS; HUMAN; HUMAN TISSUE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; SMOOTH MUSCLE FIBER; SWINE; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; CELL MOTION; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PHYSIOLOGY; PLACENTA; PREGNANCY; VASCULARIZATION;

ANIMALS; BIOMECHANICS; CELL LINE; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINE CCL2; ENDOTHELIAL CELLS; EPHRIN-B2; FEMALE; GENE EXPRESSION; HEMODYNAMICS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; MYOCYTES, SMOOTH MUSCLE; NEOVASCULARIZATION, PHYSIOLOGIC; PLACENTA; PREGNANCY; RNA, MESSENGER;

EID: 47249146982     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-12-128835     Document Type: Article

References (39)

1. Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol. 2002;3:475-486.
2. Wang HU, Chen ZF Anderson DJ. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998;93:741-753.
3. Gerety SS, Wang HU, Chen ZF Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999;4:403-414.
4. Adams RH, Wilkinson GA, Weiss C, et al. Roles of ephrin B ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999;13:295-306.
5. Poliakov A, Cotrina M, Wilkinson DG. Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev Cell. 2004;7:465-480.
6. Fuller T, Korff T, Kilian A, Dandekar G, Augustin HG. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrin B2 positive cells. J Cell Sci. 2003;116:2461-2470.
7. Hamada K, Oike Y, Ito Y, et al. Distinct roles of ephrin-B2 forward and EphB4 reverse signaling in endothelial cells. ArteriosclerThromb Vasc Biol. 2003;23:190-197.
8. Shin D, Garcia-Cardena G, Hayashi S, et al. Expression of ephrin B2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 2001;230:139-150.
9. Gale NW, Baluk P, Pan L, et al. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. Dev Biol. 2001;230:151-160.
10. le Noble F, Moyon D, Pardanaud L, et al. Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development. 2004;131:361-375.
11. Goettsch W, Augustin HG, Morawietz H. Downregulation of endothelial ephrin B2 expression by laminar shear stress. Endothelium. 2004;11:259-265.
12. Othman-Hassan K, Patel K, Papoutsi M, Rodriguez-Niedenfuhr M, Christ B, Wilting J. Arterial identity of endothelial cells is controlled by local cues. Dev Biol. 2001;237:398-409.
13. Korff T, Dandekar G, Pfaff D, et al. Endothelial ephrin B2 is controlled by microenvironmental determinants and associates context-dependently with CD31. ArteriosclerThromb Vasc Biol. 2006; 26:468-474.
14. Yu G, Luo H, Wu Y, Wu J. Ephrin B2 induces T cell costimulation. J Immunol. 2003;171:106-114.
15. Pfaff D, Fiedler U, Augustin HG. Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking. J Leukoc Biol. 2006;80:719-726.
16. Heil M, Schaper W. Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ Res. 2004;95:449-458.
17. Korff T. Kimmina S, Martiny-Baron G, Augustin HG. Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness. FASEB J. 2001; 15:447-457.
18. Korff T, Augustin HG. Tensional forces in fibrillar extracellular matrices control directional capillary sprouting. J Cell Sci. 1999;112:3249-3258.
19. Wagner AH, Guldenzoph B, Lienenluke B, Hecker MCD. 154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interaction. ArteriosclerThromb Vasc Biol. 2004;24:715-720.
20. Kim I, Ryu YS, Kwak HJ, et al. EphB ligand, ephrin B2, suppresses the VEGF-and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells. FASEB J. 2002;16:1126-1138.
21. Wagner AH, Krzesz R, Gao D, Schroeder C, CattaruzzaM, Hecker M. Decoy oligodeoxynucleotide characterization of transcription factors controlling endothelin-B receptor expression in vascular smooth muscle cells. Mol Pharmacol. 2000:58:1333-1340.
22. Hu Y, Bock G, Wick G, Xu Q. Activation of PDGF receptor alpha in vascular smooth muscle cells by mechanical stress. FASEB J. 1998;12:1135-1142.
23. Wung BS, Cheng JJ, Hsieh HJ, Shyy YJ, Wang DL. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ Res. 1997;81:1-7.
24. Heil M, Ziegelhoeffer T Wagner S, et al. Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2. Circ Res. 2004;94:671-677.
25. Ito WD, Arras M, Winkler B, Scholz D, Schaper J, Schaper W. Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res. 1997;80:829-837.
26. Adams RH. Molecular control of arterial-venous blood vessel identity. J Anat. 2003;202:105-112.
27. Vihanto MM, Plock J, Erni D, Frey BM, Frey FJ, Huynh-Do U. Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin. FASEB J. 2005;19:1689-1691.
28. Schaper W, Buschmann I. Arteriogenesis, the good and bad of it. Cardiovasc Res. 2001;43:835-837.
29. Schaper W, Scholz D. Factors regulating arteriogenesis. ArteriosclerThromb Vasc Biol. 2003;23:1143-1151.
30. Resnick N, Einav S, Chen-Konak L, Zilberman M, Yahav H, Shay-Salit A. Hemodynamic forces as a stimulus for arteriogenesis. Endothelium. 2003; 10:197-206.
31. Deindl E, Buschmann I, Hoefer IE, et al. Role of ischemia and of hypoxia-inducible genes in arteriogenesis after femoral artery occlusion in the rabbit. Circ Res. 2001;89:747-759.
32. Rabkin-Aikawa E, Aikawa M, Farber M, et al. Clinical pulmonary autograft valves: pathologic evidence of adaptive remodelling in the aortic site. J Thorac Cardiovasc Surg. 2004;128:552-561.
33. Martiny-Baron G, Korff T, Schaffner F, et al. Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia. 2004;6:248-257.
34. Kertesz N, Krasnoperov V, Reddy R, et al. The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-Ephrin B2 interaction, modulates angiogenesis, and inhibits tumor growth. Blood. 2006;107:2330-2338.
35. Foo SS, Turner CJ, Adams S, et al. Ephrin-B2 controls cell motility and adhesion during bloodvessel-wall assembly. Cell. 2006;124:161-173.
36. Oike Y, Ito Y, Hamada K, et al. Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Blood. 2002;100:1326-1333.
37. Fujii T Yonemitsu Y, Onimaru M, et al. Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway. Arterioscler Thromb Vasc Biol. 2006;26:2483-2489.
38. Luo H, Yu G, Tremblay J, Wu J. EphB6-null mutation results in compromised T cell function. J Clin Invest. 2004;114:1762-1773.
39. Duncan GS, Andrew DP, Takimoto H, et al. Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1 -independent functions. J Immunol. 1999;162:3022-3030.