Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells

Blood

Volumn 100, Issue 4, 2002, Pages 1326-1333

  Oike, Yuichi ^a,b,c   Ito, Yasuhiro ^a,b,c   Hamada, Koichi ^a,b,c   Zhang, Xiu Qin ^a,b,c   Miyata, Keishi ^a,b,c   Arai, Fumio ^a,b,c   Inada, Tomohisa ^a,b,c   Araki, Kimi ^a,b,c   Nakagata, Naomi ^a,b,c   Takeya, Motohiro ^a,b,c   Kisanuki, Yaz Y ^a,b,c   Yanagisawa, Masashi ^a,b,c   Gale, Nicholas W ^a,b,c   Suda, Toshio ^a,b,c,d  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c REGENERON PHARMACEUTICALS INC   (United States)

^d KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN B2; GENE PRODUCT; PROTEIN EPHB; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; AORTA DISSECTING ANEURYSM; ARTICLE; ASCENDING AORTA; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; SUDDEN DEATH; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

EID: 0037103260     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v100.4.1326.h81602001326_1326_1333     Document Type: Article

References (43)

1. Mechanisms of angiogenesis
2. Signaling vascular morphogenesis and maintenance
3. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
4. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
5. Failure of blood-island formation and vasculogenesis in FLK-1-deficient mice
6. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
7. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
8. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
9. Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
10. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains
11. Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells
12. Ephrins and their receptors: A repulsive topic?
13. The ephrins and Eph receptors in neural development
14. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor EphB4
15. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
16. Roles of ephrinB ligands and EphB receptors in cardiovascular development: Demarcation of arterial/ venous domains, vascular morphogenesis, and sprouting angiogenesis
17. Eph receptors and ligands comprise two major specificity subclasses, and are reciprocally compartmentalized during embryogenesis
18. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
19. Tyrosine phosphorylation of transmembrane ligands for Eph receptors
20. The cytoplasmic domain of the ligand ephrin-B2 is required for vascular morphogenesis but not cranial neural crest
21. + endothelial cells
22. Efficient selection for high-expression transfectants with a novel eukaryotic vector
23. Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression
24. Targeting integration of DNA using mutant IoxP sites in embryonic stem cells
25. A novel ES cell line, TT2, with high germline-differentiating potency
26. Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: Implication for a dominant-negative mechanism
27. Efficiency of recombination by Cre transient expression in embryonic stem cells: Comparison of various promoters
28. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family
29. Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis
30. VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis
31. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells
32. Tie-2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo
33. Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding
34. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
35. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth muscle cells
36. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth
37. Eph receptors and ephrins: Effectors of morphogenesis
38. The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis
39. Regulated cleavage of a contact-mediated axon repellent
40. The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of brachial neural crest cells
41. A novel transgenic technique that allows specific marking of the neural crest cells lineage in mice
42. Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration