Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth factor in HaCaT keratinocytes

Journal of Investigative Dermatology

Volumn 114, Issue 1, 2000, Pages 83-87

  Harris, Ian R ^a   Höppner, Hendrik ^a   Siefken, Wilfried ^a   Farrell, Angela M ^b   Wittern, Klaus Peter ^a  

^a BEIERSDORF AG   (Germany)

^b NONE

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A synthase; 3 hydroxy 3 methylglutaryl coenzyme A reductase; Activator protein 1; Cholesterol; Epidermal growth factor; Sterol regulatory element binding protein

Indexed keywords

EPIDERMAL GROWTH FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; INSULIN; MESSENGER RNA;

ARTICLE; CELL LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REPORTER GENE; STRUCTURE ACTIVITY RELATION;

EID: 0034037186     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00822.x     Document Type: Article

References (41)

1. Amorosa LF, Khachadurian AK, Harns JN, Schneider SH, Fung CH: The effects of triiodothyonine, hydrocortisone and insulin on lipid synthesis by cultured fibroblasts preincubated in a serum-free medium. Biochim Biophys Acta 792:192-198, 1984
2. Bennett MK, Lopez JM, Sanchez HB, Osborne TF: Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways. J Biol Chem 270:25578-25583, 1995
3. Bortz W: Noradrenalin-induced increase in hepatic cholesterol synthesis and its blockade by puromycin. Biochim Biophys Acta 152:619-626, 1968
4. Denda M, Brown B, Elias PM, Feingold KR: Epidermal injury stimulates prenylation in the epidermis of hairless mice. Arch Dermatol Res 289:104-110, 1997
5. Deverey R, O'Donnell L, Tomkin GH: Effect of catecholamines on hepatic rate-limiting enzymes of cholesterol metabolism in normally fed and cholesterol-fed rabbits. Biochim Biophys Acta 887:173-181, 1986
6. Edwards PA: The influence of catecholamines and cyclic AMP on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and lipid biosynthesis in isolated rat hepatocytes. Arch Biochem Biophys 170:188-203, 1975
7. Edwards PA, Lemongello D, Fogelman AM: The effect of glucagon, norepinepherine, and dibutryl cyclic AMP on cholesterol efflux and on the activity of 3-hydroxy-3-methylglutaryl CoA reductase in rat hepatocytes. J Lipid Res 20:2-7, 1979
8. Ericsson J, Jackson SM, Lee BC, Edwards PA: Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proc Natl Acad Sci USA 93:945-950, 1996
9. Feingold KR, Man MQ, Menon GK, Cho SS, Brown BE, Elias PM: Cholesterol synthesis is required for cutaneous barrier function in mice. J Clin Invest 86:1738-1745, 1990
10. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM: The aged epidermal permeability barrier. J Clin Invest 95:2281-2290, 1995
11. Ghadially R, Brown BE, Hanley K, Reed JT, Feingold KR, Elias PM: Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice. J Invest Dermatol 106:1064-1069, 1996
12. Goldstein JL, Brown MS: Regulation of the mevalonate pathway. Nature 343:425-430, 1990
13. Greenberg ME, Hermanowski AL, Ziff E: Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. Mol Cell Biol 6:1050-1057, 1986
14. Harris IR, Farrell AM, Grunfeld C, Holleran WM, Elias PM, Feingold KR: Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis. J Invest Dermatol 109:783-787, 1997
15. Harris IR, Farrell AM, Holleran WM, Jackson S, Grunfeld C, Elias PM, Feingold KR: Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis. J Lipid Res 39:412-422, 1998
16. Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X: SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA 90:11603-11607, 1993
17. Ingebritsen TS, Geelsen JH, Parker RA, Evenson KJ, Gibson DM: Modulation of hydroxymethylglutaryl-CoA reductase activity, reductase kinase activity, and cholesterol synthesis in rat hepatocytes in response to insulin and glucagon. J Biol Chem 254:9986-9989, 1979
18. Jiang G, McKenzie TL, Conrad DG, Shechter I: Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase. J Biol Chem 268:12818-12824, 1993
19. Kotzka J, Müller-Wieland D, Koponen A, et al: ADD1/SREBP-Ic mediates insulin-induced gene expression linked to the MAP kinase pathway. Biochem Biophys Res Commun 249:375-379, 1998
20. Liou A, Elias PM, Grunfeld C, Feingold KR, Wood LC: Amphiregulin and nerve growth factor expression are regulated by barrier status in murine epidermis. J Invest Dermatol 108:73-77, 1997
21. Lopez JM, Bennett MK, Sanchez HB, Rosenfeld JM, Osborne TF: Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Proc Natl Acad Sci USA 93:1049-1053, 1996
22. Menon GK, Feingold KR, Moser AH, Brown BE, Elias PM: De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements. J Lipid Res 26:418-127, 1985
23. Menon GK, Feingold KR, Mao-Qiang M, Schaude M, Elias PM: Structural basis for the barrier abnormality following inhibition of HMG-CoA reductase in murine epidermis. J Invest Dermatol 98:209-219, 1992
24. Nepokroeff CM, Lakshmanan MR, Ness GC, Dugan RE, Porter JW: Regulation of the diurnal rhythm of rat liver β-hydroxy β-methylglutaryl coenzyme A reductase activity by insulin, glucagon, cyclic AMP and hydrocortisone. Arch Biochem Biophys 160:387-393, 1974
25. Osborne TF, Rosenfeld JM: Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation. Curr Opin Lipidol 9:137-140, 1998
26. Proksch E, Elias PM, Feingold KR: Regulation of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase activity in murine epidermis: Modulation of enzyme content and activation state by barrier requirements. J Clin Invest 85:874-882, 1990
27. Proksch E, Elias PM, Feingold KR: Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements. Biochem Biophys Acta 1083:71-79, 1991a
28. Proksch E, Feingold KR, Man M-Q, Elias PM: Barrier function regulates epidermal DNA synthesis. J Clin Invest 87:1668-1673, 1991b
29. Rogers J, Harding C, Mayo A, Banks J, Rawlings A: Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res 288:765-770, 1996
30. Rossi A, Jang S-I, Ceci R, Steinert PM, Markova NG: Effect of AP-1 transcription factors on the regulation of transcription in normal human keratinocytes. J Invest Dermatol 110:34-40, 1998
31. Schmidt R, Parish EJ, Dionisius V, et al: Modulation of cellular cholesterol and its effect on cornified envelope formation in cultured human epidermal keratinocytes. J Invest Dermatol 97:771-775, 1991
32. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575-1584, 1996
33. Smith JR, Osborne TF, Brown MS, Goldstein JL, Gil G: Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Biol Chem 263:18480-18487, 1988
34. Stanulis-Praeger BM, Gilchrest BA: Growth factor responsiveness declines during adulthood for human skin-derived cells. Mechanisms Ageing Dev 35:185-198, 1986
35. Vallett SM, Osborne TF: Two separate sites contribute to AP-1 activation of the promoter for 3-hydroxy-3-methylglutaryl coenzyme A synthase. Nucleic Acids Res 22:5184-5189, 1994
36. Vallett SM, Sanchez HB, Rosenfeld JM, Osborne TF: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J Biol Chem 271:12247-12253, 1996
37. Wang X, Sato R, Brown MS, Hua X, Goldstein JL: SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77:53-62, 1994
38. Welter JF, Eckert RL: Differential expression of the fos and jun family members c-fos, fosB, Fra-1, Fra-2, c-jun, junB and junD during human epidermal keratinocyte differentiation. Oncogene 11:2681-2687, 1995
39. Wilkin DJ, Edwards PA: Calcium ionophore treatment impairs the sterol-mediated suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, and farnesyl diphosphate synthetase. J Biol Chem 267:2831-2836, 1992
40. Wilkin DJ, Katsunal SY, Edwards PA: Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. J Biol Chem 265:4607-4614, 1990
41. Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS: SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75:187-197, 1993