Naturally occurring disulfide-bound dimers of three-fingered toxins: A paradigm for biological activity diversification

Journal of Biological Chemistry

Volumn 283, Issue 21, 2008, Pages 14571-14580

  Osipov, Alexey V ^a   Kasheverov, Igor E ^a   Makarova, Yana V ^a   Starkov, Vladislav G ^a   Vorontsova, Olga V ^a   Ziganshin, Rustam Kh ^a   Andreeva, Tatyana V ^a   Serebryakova, Marina V ^b   Benoit, Audrey ^c   Hogg, Ronald C ^c   Bertrand, Daniel ^c   Tsetlin, Victor I ^a   Utkin, Yuri N ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b FEDERAL RESEARCH AND CLINICAL CENTER OF PHYSICAL CHEMICAL MEDICINE OF FEDERAL MEDICAL BIOLOGICAL AGENCY   (Russian Federation)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOACTIVITY; DICHROISM; DIMERS; METABOLITES; MONOMERS; OPTICAL PROPERTIES;

BINDING PROTEINS; BIOLOGICAL ACTIVITIES; CIRCULAR DICHROISM MEASUREMENTS; COBRA VENOMS; CYTOTOXINS; HETERO DIMERS; HOMODIMER; NICOTINIC ACETYLCHOLINE RECEPTORS; XENOPUS OOCYTES;

OLIGOMERS;

BUNGAROTOXIN RECEPTOR; COBROTOXIN; DIMER; DISULFIDE; THREE FINGERED TOXIN; TOXIN; UNCLASSIFIED DRUG; ALPHA-COBRATOXIN;

ALKYLATION; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LYMNAEA; NONHUMAN; OOCYTE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; TORPEDO; XENOPUS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; DIMERIZATION; GEL CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SNAKE;

NAJA KAOUTHIA;

ANIMALS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; COBRA; COBRA NEUROTOXIN PROTEINS; DIMERIZATION; DISULFIDES; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 47249117482     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802085200     Document Type: Article

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