The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice

International Journal of Cancer

Volumn 123, Issue 5, 2008, Pages 991-997

  Su, Weidong ^a   Necela, Brian M ^a   Fujiwara, Kosaku ^b   Kurakata, Shinichi ^b   Murray, Nicole R ^a   Fields, Alan P ^a   Thompson, E Aubrey ^a  

^a MAYO CLINIC   (United States)

^b DAIICHI SANKYO INC   (United States)

Author keywords

Azoxymethane induced colon tumors; Colon cancer chemoprevention; Colon carcinogenesis; Nuclear receptors; PPAR

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTINEOPLASTIC AGENT; AZOXYMETHANE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; RS 5444; CARCINOGEN; RS5444;

ADENOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER INCIDENCE; CANCER INHIBITION; CARCINOMA IN SITU; CELL NUCLEUS; COLON CARCINOGENESIS; COLON TUMOR; CONTROLLED STUDY; CRYPT CELL; DNA SYNTHESIS; DRUG EFFICACY; DRUG MECHANISM; DYSPLASIA; FEMALE; HISTOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TREATMENT WITHDRAWAL; ANIMAL; C57BL MOUSE; CELL TRANSFORMATION; CHEMICALLY INDUCED DISORDER; DISEASE COURSE; DRUG EFFECT; DRUG POTENTIATION; IMMUNOHISTOCHEMISTRY; PATHOLOGY;

ANIMALS; ANTICARCINOGENIC AGENTS; AZOXYMETHANE; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; DISEASE PROGRESSION; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; PPAR GAMMA; THIAZOLIDINEDIONES;

EID: 47249104700     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23640     Document Type: Article

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