Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole

Food and Chemical Toxicology

Volumn 46, Issue 8, 2008, Pages 2616-2628

  Stierum, Rob ^a   Conesa, Ana ^a   Heijne, Wilbert ^a   Ommen, Ben van ^a   Junker, Karin ^a   Scott, Mary P ^b,c   Price, Roger J ^b,c   Meredith, Clive ^b   Lake, Brian G ^b,c   Groten, John ^a  

^a TNO   (Netherlands)

^b BIBRA INTERNATIONAL   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Butylated hydroxytoluene; Curcumin; Drug metabolism; Mixtures; p53; Peroxisome proliferation; Propyl gallate; Rat; Thiabendazole; Toxicogenomics

Indexed keywords

BUTYLCRESOL; COMPLEMENTARY DNA; CURCUMIN; CYANIDE; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C6; CYTOCHROME P450 3A9; CYTOCHROME P450 4A3; ENOYL COENZYME A HYDRATASE; ENZYME; GALLIC ACID PROPYL ESTER; GLUTATHIONE TRANSFERASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; PALMITOYL COENZYME A; PHYTANOYL COENZYME A DIOXYGENASE; PROTEIN KINASE C BETA; PROTEIN P53; RNA; SERUM ALBUMIN; TIABENDAZOLE; TRANSCRIPTOME;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; DNA MICROARRAY; FOOD POISONING; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER; MALE; METABOLISM; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BODY WEIGHT; BUTYLATED HYDROXYTOLUENE; CURCUMIN; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2B1; DATA INTERPRETATION, STATISTICAL; DIET; DNA, COMPLEMENTARY; FOOD ADDITIVES; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUTATHIONE TRANSFERASE; LIVER; MALE; ORGAN SIZE; OXIDATION-REDUCTION; PALMITOYL COENZYME A; PROPYL GALLATE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROID HYDROXYLASES; THIABENDAZOLE;

RATTUS;

EID: 47149103614     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.04.019     Document Type: Article

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