An analysis of the possibility for health implications of joint actions and interactions between food additives

Regulatory Toxicology and Pharmacology

Volumn 31, Issue 1, 2000, Pages 77-91

  Groten, J P ^a   Butler, W ^e   Feron, V J ^a   Kozianowski, G ^b   Renwick, A G ^c   Walker, R ^d  

^a TNO   (Netherlands)

^b Sudzucker AG   (Germany)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY OF SURREY   (United Kingdom)

^e NONE

Author keywords

ADIs; Food additives; Interactions; Joint actions; Risk assessment

Indexed keywords

ALGINIC ACID PROPYLENE GLYCOL ESTER; AMARANTH; ASPARTAME; BUTYLATED HYDROXYANISOLE; CITRIC ACID TRIETHYL ESTER; CURCUMIN; FOOD ADDITIVE; GALLIC ACID PROPYL ESTER; MACROGOL STEARATE; METHENAMINE; NATAMYCIN; NITRATE; POLYOXYETHYLENE; POLYSORBATE; SORBITAN ESTER; STANNOUS CHLORIDE; SUCROSE ACETATE ISOBUTYRATE; SULFITE; SULFUR DIOXIDE; SUNSET YELLOW; TARTRAZINE; TIABENDAZOLE;

ADRENAL DISEASE; ARTICLE; BLADDER DISEASE; BLOOD TOXICITY; DRUG MECHANISM; EVALUATION; FOOD POISONING; FOOD SAFETY; GASTROINTESTINAL TOXICITY; HUMAN; LIVER TOXICITY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; TARGET ORGAN; TOXICOKINETICS;

AMARANTHUS CAUDATUS; ANIMALIA;

EID: 0034116113     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1999.1356     Document Type: Article

References (46)

1. Aix L., Rey-Grobellet X., Larrieu G., Lesca P., Galtier P. Thiabendazole is an inducer of cytochrome P4501A1 in cultured rabbit hepatocytes. Biochem. Biophys. Res. Commun. 202:1994;1483-1489.
2. Allmark M. G., Mannell W. A., Grice H. C. Chronic toxicity studies of food colours. III. Observations on the toxicity of malachite green, new coccine and nigrosine in rats. J. Pharm. Pharmacol. 9:1957;622-628.
3. Ambrose A. M., Booth A. N., DeEds F., Cox A. J. A toxicological study of biphenyl, a citrus fungistat. Food Res. 25:1960;328-336.
4. Bauer L. A., Blouin R. A. Age and phenytoin kinetics in adult epileptics. Clin. Pharmacol. Ther. 31:1982;301-304.
5. Bliss C. I. The toxicity of poisons applied jointly. Ann. Appl. Biol. 26:1939;585-615.
6. Booth A. N., Ambrose A. M., DeEd F. Fed. Proc. 15:1956;403.
7. Borzelleca J. F., Capen C. C., Hallagan J. B. Lifetime toxicity/carcinogenicity study of FD&C Red No. 3 (erythrosine) in rats. Food Chem. Toxicol. 25:1987;723-733.
8. Cassee F. R., Groten J. P., Feron V. J. Changes in the nasal epithelium of rats exposed by inhalation to mixtures of formaldehyde, acetaldehyde, and acrolein. Fundam. Appl. Toxicol. 9:1996a;208-218.
9. Cassee F. R., Groten J. P., Feron V. J. Combined exposure of rat upper respiratory tract epithelium to aldehydes. Hum. Exp. Toxicol. 13:1996b;726.
10. Cassee F. R., Groten J. P., Van Bladeren P. J., Feron V. J. Toxicological evaluation and risk assessment of chemical mixtures. Crit. Rev. Toxicol. 28:1998;73-101.
11. Clode, S. A, Hooson, J, Butler, W. H, and, Conning, D. M. 1982, Long-term study in rats with Amaranth using animals exposed in utero, BIBRA Report No. 242/1/82. Unpublished report from the European Colours Steering Group submitted to WHO.
12. Depner M. Influence of gallic acid esters on drug-metabolizing enzymes of rat liver. Food Chem. Toxicol. 20:1982;507-511.
13. Dourson M. L., Felter S. P., Robinson D. Evolution of science-based uncertainty factors for noncancer risk assessment. Regul. Toxicol. Pharmacol. 24:1996;108-120.
14. Ford, G. P, Butler, W. H, and, Gaunt, I. F. 1983, Report of the effects of Amaranth on renal calcification in the mature rat - A 28 day and 90 day study, BIBRA Report No. 453/2/83. Unpublished report from the European Colours Steering Group submitted to WHO.
15. Gardner D. F., Utiger R. D., Schwartz S. L., Witorsch P., Meijers B., Braverman L. E., Witorsch R. J. Effects of oral erythrosine (2′,4′,5′,7′-tetraiodofluorescein) on thyroid function in normal men. Toxicol. Appl. Pharmacol. 91:1987;299-304.
16. Groten J. P., Schoen E. D., van Bladeren P. J., Kuper C. F., van Zorge J. A., Feron V. J. Subacute toxicity of a combination of nine chemicals in rats: Detecting interactive effects with a two level factorial design. Fundam. Appl. Toxicol. 36:1997;15-29.
17. Hodge H. C., Maynard E. A., Blanchet H. J., Spencer H. C., Row V. K. Toxicological studies of orthophenylphenol. J. Pharmacol. Exp. Ther. 104:1952;202.
18. Höring H. Zum Einfluss von subchronischer Nitratapplikation mit Trinkwasser auf die Schilddrüse der Ratte (Radio jod test). Gesundheit und Umwelt. 4:1985;1-15.
19. Jahreis G., Hesse V., Schone F., Hennig A. Effect of chronic dietary nitrate and different iodine supply on porcine thyroid function, somatomedin-C level and growth. Exp. Clin. Endocrinol. 88:1986;242-248.
20. Jennings A. S., Schwartz S. L., Balter N. J., Gardner D., Witorsch R. J. Effects of oral erythrosine (2′,4′,5′,7′-tetraiodofluorescein) on the pituitary-thyroid axis in rats. Toxicol. Appl. Pharmacol. 103:1990;549-556.
21. Jonker D., Woutersen R. A., van Bladeren P. J., Til H. P., Feron V. J. 4-week oral toxicity study of a combination of eight chemicals in rats: Comparison with the toxicity of the individual compounds. Food Chem. Toxicol. 28:1990a;623-631.
22. Jonker D., Woutersen R. A., van Bladeren P. J., Til H. P., Feron V. J. Sub-acute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: Comparison with the toxicity of the individual compounds. Food Chem. Toxicol. 31:1990b;125-136.
23. Jonker D., Jones M. A., van Bladeren P. J., Woutersen R. A., Til H. P., Feron V. J. Acute (24 hr) toxicity of a combination of four chemicals in rats compared with the toxicity of the individual compounds. Food Chem. Toxicol. 31:1993;45-52.
24. Jonker D., Woutersen R. A., Feron V. J. The additivity assumption tested for combinations of similarly acting nephrotoxicants. Food Chem. Toxicol. 34:1996;1075-1083.
25. Kangas, L, Farrell, D, and, Osborne, B. E. 1989, A 14-week oral toxicity study in the albino rat. Unpublished Report No. 84114 (TT89-9014) from Bio-Research Laboratories, Canada. Submitted to WHO by MSD Research Laboratory, Lauterbach, Germany.
26. Kelly, C. M, and, Daly, I. W. 1988, A 60-day study to investigate the effects of FD&C Red No. 3 on thyroid economy in male Sprague-Dawley rats, Bio-Dynamics Inc. Project No. 88-3378. Report dated December 7, 1988.
27. Kelly, C. M, and, Daly, I. W. 1989. A 60-day study to investigate the effects of FD&C Red No. 3 on thyroid economy in male Sprague-Dawley rats, Bio-Dynamics Inc. Project No. 88-3378. Report dated August 2, 1989. Submitted to WHO by Certified Color Manufacturers' Association, Washington, DC.
28. Manson M. M., Ball M. M., Barrett M. C., Clark H. L., Judah D. J., Williamson G., Neal G. E. Mechanism of action of chemopreventive agents in rat liver: Induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism. Carcinogenesis. 18:1997;1729-1738.
29. Mason, P. L, et al., 1974. Long-term toxicity study of Ponceau 4R in mice, Unpublished Report No. 1/1974. submitted to WHO by the British Industrial Biological Research Association.
30. Myers, B. A., and Lankas, G. R.1990. A 14-week dietary toxicity study in rats, Unpublished Report No. HLA 284-169 (TT90-9002) from Hazleton Laboratories, U.S.A., and Merck, Sharp & Dohme Research Laboratories, U.S.A. Submitted to WHO by MSD Research Laboratory, Lauterbach, Germany.
31. Oser, B. L.1959. Unpublished report by Food and Drug Research Lab. Inc., submitted to WHO by International Salt Co. Inc.
32. Rao C. V., Simi B., Reddy B. S. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis. 14:1993;2219-2225.
33. Renwick A. G. Safety factors and establishment of acceptable daily intakes. Food Addit. Contam. 8:1991;135-150.
34. Renwick A. G. Data-derived safety factors for the evaluation of food additives and environmental contaminants. Food Addit. Contam. 10:1993;275-305.
35. Renwick A. G., Lazarus N. R. Human variability and noncancer risk assessment - An analysis of the default uncertainty factor. Regul. Toxicol. Pharmacol. 27:1998;3-20.
36. Rey-Grobellet X., Ferre N., Eeckhoutt C., Larrieu G., Pineau T., Galtier P. Structural requirements for the induction of cytochromes P450 by benzimidazole antihelmintic derivatives in cultured rabbit hepatocytes. Biochem. Biophys. Res. Commun. 220:1996;789-794.
37. Sefner W. Zum Einfluss von subchronischer nitratapplikation mit Trink-wasser auf die Schilddrüse dere Ratte (Morphologische untersuchungen). Gesundheit und Umwelt. 4:1985;16-30.
38. Silber B. M., Holford N. H. G., Riegelman S. Dose-dependent elimination of propranolol and its major metabolites in humans. J. Pharm. Sci. 72:1983;725-732.
39. Singh A., Singh S. P., Bamezi R. Effect of Arecoline on the curcumin-modulated hepatic biotransformation system enzymes in lactating mice and translactationally exposed F1 pups. Nutr. Cancer. 25:1996;101-110.
40. Speijers, G. J. A, Janssen, G. B, Wallbrink-de Drieu, Y, van Leeuwen, F. X. R, Loenen, H. A, Krajnc-Franken, M. A. M, Vaessen, H. A. M. G, and, Wester, P. W. 1993, Subchronic toxicity of propyl-gallate, RIVM Report No. 618311002 (Draft) Rijksinstituut Voor Volksgezondheid en Milieuhygiene, Bilthoven, The Netherlands.
41. Stevenson, B. I, et al., 1981. Long term study in rats with Ponceau 4R using animals exposed, in utero, Vol, 1, Unpublished BIBRA report, 293/2/81. submitted to WHO by the UK Colours Steering Group.
42. Sun B., Kinoshita T., Kimura M., Ushio F. Differential induction of isozymes of drug-metabolizing enzymes by butylated hydroxytoluene in mice and Chinese hamsters. Food Chem. Toxicol. 34:1996;595-601.
43. Sun B., Fukuhara M. Effects of co-administration of butylated hydroxytoluene, butylated hydroxyanisole and flavonoids on the activation of mutagens and drug-metabolising enzymes in mice. Toxicology. 122:1997;61-72.
44. Suzan M., Rao M. N. A. Induction of glutathione S-transferase activity in mice. Arzn.-Forsch/Drug Res. 42:1992;962-964.
45. Principles for the Safety Assessment of Food Additives and Contaminants in Food. 1987;World Health Organisation, Geneva.
46. Assessing Human Health Risks of Chemicals: Derivation of Guidance Values for Health-Based Exposure Limits. 1994;World Health Organisation, Geneva.