Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel potentiators of defective ΔF508-cystic fibrosis transmembrane conductance regulator chloride channel gating

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 3, 2006, Pages 537-540

  Suen, Yat Fan ^a   Robins, Lori ^a   Yang, Baoxue ^b   Verkman, A S ^b   Nantz, Michael H ^a   Kurth, Mark J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Activator; CFTR; Cystic fibrosis; Potentiator; Sulfonamide

Indexed keywords

AMIDE; CHLORIDE CHANNEL; IODIDE; N ETHYL 6 (ETHYLPHENYLSULFAMOYL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXAMIDE; SULFONAMIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; REACTION ANALYSIS;

CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNEL GATING; MODELS, CHEMICAL; QUINOLONES; SULFONAMIDES;

EID: 29544440095     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.10.050     Document Type: Article

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