Development of substituted benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel

Journal of Biological Chemistry

Volumn 274, Issue 39, 1999, Pages 27415-27425

  Becq, Frédéric ^a,g   Mettey, Yvette ^b   Gray, Mike A ^c   Galietta, Luis J V ^d   Dormer, Robert L ^e   Merten, Marc ^f   Métayé, Thierry ^g   Chappe, Valérie ^a   Marvingt Mounir, Cécie ^b   Zegarra Moran, Olga ^d   Tarran, Robert ^c   Bulteau, Laurence ^g   Dérand, Renaud ^g   Pereira, Malcome M C ^e   McPherson, Margaret A ^e   Rogier, Christian ^g   Joffre, Michel ^g   Argent, Barry E ^c   Sarrouilhe, Denis ^b   Kammouni, Wafa ^f   Figarella, Catherine ^f   Verrier, Bernard ^a   Gola, Maurice ^a   Vierfond, Jean Michel ^b   more..

^a UPR CNRS no 9024   (France)

^b Faculte de Medicine et de Pharmacie   (France)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d G GASLINI INSTITUTE   (Italy)

^e CARDIFF UNIVERSITY   (United Kingdom)

^f AIX MARSEILLE UNIVERSITY   (France)

^g UNIVERSITÉ DE POITIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXY 10 CHLOROBENZO[C]QUINOLIZINIUM; 6 HYDROXY 7 CHLOROBENZO[C]QUINOLIZINIUM; ADENOSINE TRIPHOSPHATE; CHLORIDE CHANNEL; CHLORIDE ION; CYCLIC AMP; GLIBENCLAMIDE; MUCIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEINASE INHIBITOR; QUINOLIZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG ACTIVATION; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SHORT CIRCUIT CURRENT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CILIA; CRICETINAE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG DESIGN; FEMALE; FORSKOLIN; GLYBURIDE; HUMANS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MOLECULAR STRUCTURE; NASAL MUCOSA; PATCH-CLAMP TECHNIQUES; QUINOLINES; QUINOLIZINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0033600763     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.39.27415     Document Type: Article

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