Decreased expression of haem oxygenase-1 by alveolar macrophages in idiopathic pulmonary fibrosis

European Respiratory Journal

Volumn 31, Issue 5, 2008, Pages 1030-1036

  Ye, Q ^a,d   Dalavanga, Y ^a   Poulakis, N ^a   Sixt, S U ^b   Guzman, J ^c   Costabel, U ^a,e  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e RUHRLANDKLINIK   (Germany)

Author keywords

Alveolar macrophage; Cytokine; Haem oxygenase 1; Interstitial lung disease

Indexed keywords

HAEM OXYGENASE 1; INTERLEUKIN 12; INTERLEUKIN 18; OXIDOREDUCTASE; UNCLASSIFIED DRUG; HEME OXYGENASE 1;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROSING ALVEOLITIS; HUMAN; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SARCOIDOSIS; SCORING SYSTEM; ALLERGIC PNEUMONITIS; CASE CONTROL STUDY; CYTOLOGY; ENZYMOLOGY; LUNG FIBROSIS; METABOLISM; MIDDLE AGED;

AGED; ALVEOLITIS, EXTRINSIC ALLERGIC; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; FEMALE; HEME OXYGENASE-1; HUMANS; INTERLEUKIN-12; INTERLEUKIN-18; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; PULMONARY FIBROSIS; SARCOIDOSIS, PULMONARY;

EID: 47049088662     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00125407     Document Type: Article

References (42)

1. American Thoracic Society, European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment, international consensus statement. Am J Respir Crit Care Med 2000; 161: 646-664.
2. Kinnula VL, Fattman CL, Tan RJ, Oury TD. Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am J Respir Crit Care Med 2005; 172: 417-422.
3. Cantin AM, North SL, Fells GA, Hubbard RC, Crystal RG. Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis. J Clin Invest 1987; 79: 1665-1673.
4. Nathan CF, Brukner LH, Silverstein SC, Cohn ZA. Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. J Exp Med 1979; 149: 84-99.
5. Kuwano K, Nakashima N, Inoshima I, et al. Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias. Eur Respir J 2003; 21: 232-240.
6. Lenz AG, Costabel U, Maier KL. Oxidized BAL fluid proteins in patients with interstitial lung diseases. Eur Respir J 1996; 9: 307-312.
7. Maier K, Leuschel L, Costabel U. Increased levels of oxidized methionine residues in bronchoalveolar lavage fluid proteins from patients with idiopathic pulmonary fibrosis. Am Rev Respir Dis 1991; 143: 271-274.
8. Montuschi P, Ciabattoni G, Paredi P, et al. 8-Isoprostane as a biomarker of oxidative stress in interstitial lung diseases. Am J Respir Crit Care Med 1998; 158: 1524-1527.
9. Meyer A, Buhl R, Magnussen H. The effect of oral Nacetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis. Eur Respir J 1994; 7: 431-436.
10. Tiitto L, Kaarteenaho-Wiik R, Sormunen R, et al. Expression of the thioredoxin system in interstitial lung disease. J Pathol 2003; 201: 363-370.
11. Peltoniemi M, Kaarteenaho-Wiik R, Säily M, et al. Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-b in vitro and in interstitial lung diseases in vivo. Hum Pathol 2004; 35: 1000-1007.
12. Lakari E, Pääkkö P, Pietarinen-Runtti P, Kinnula VL. Manganese superoxide dismutase and catalase are coordinately expressed in the alveolar region in chronic interstitial pneumonias and granulomatous diseases of the lung. Am J Respir Crit Care Med 2000; 161: 615-621.
13. Morse D, Choi AM. Heme oxygenase-1: from bench to bedside. Am J Respir Crit Care Med 2005; 172: 660-670.
14. Maestrelli P, El Messlemani AH, De Fina O, et al. Increased expression of heme oxygenase (HO)-1 in alveolar spaces and HO-2 in alveolar walls of smokers. Am J Respir Crit Care Med 2001; 164: 1508-1513.
15. Horváth I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, Barnes PJ. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax 1998; 53: 668-672.
16. Lee PJ, Alam J, Sylvester SL, Inamdar N, Otterbein L, Choi AM. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury. Am J Respir Cell Mol Biol 1996; 14: 556-568.
17. Zhou H, Lu F, Latham C, Zander DS, Visner GA. Heme oxygenase-1 expression in human lungs with cystic fibrosis and cytoprotective effects against Pseudomonas aeruginosa in vitro. Am J Respir Crit Care Med 2004; 170: 633-640.
18. Lu F, Zander DS, Visner GA. Increased expression of heme oxygenase-1 in human lung transplantation. J Heart Lung Transplant 2002; 21: 1120-1126.
19. Maestrelli P, Páska C, Saetta M, et al. Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients. Eur Respir J 2003; 21: 971-976.
20. Moller DR, Forman JD, Liu MC, et al. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol 1996; 156: 4952-4960.
21. Chen B, Tong Z, Nakamura S, Costabel U, Guzman J. Production of IL-12, IL-18 and TNF-α by alveolar macrophages in hypersensitivity pneumonitis. Sarcoidosis Vasc Diffuse Lung Dis 2004; 21: 199-203.
22. Majumdar S, Li D, Ansari T, et al. Different cytokine profiles in cryptogenic fibrosing alveolitis and fibrosing alveolitis associated with systemic sclerosis: a quantitative study of open lung biopsies. Eur Respir J 1999; 14: 251-257.
23. Hunninghake GW, Costabel U, Ando M, et al. ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc Diffuse Lung Dis 1999; 16: 149-173.
24. Yamasaki H, Ando M, Brazer W, Center DM, Cruikshank WW. Polarized type 1 cytokine profile in bronchoalveolar lavage T cells of patients with hypersensitivity pneumonitis. J Immunol 1999; 163: 3516-3523.
25. Klech H, Pohl W. Technical recommendations and guidelines for bronchoalveolar lavage (BAL). Report of the European Society of Pneumology Task Group. Eur Respir J 1989; 2: 561-585.
26. Costabel U, Bross KJ, Matthys H. The immunoperoxidase slide assay. A new method for the demonstration of surface antigens on bronchoalveolar lavage cells. Bull Eur Physiopathol Respir 1985; 21: 381-387.
27. Lakari E, Pylkäs P, Pietarinen-Runtti P, Pääkkö P, Soini Y, Kinnula VL. Expression and regulation of hemeoxygenase 1 in healthy human lung and interstitial lung disorders. Hum Pathol 2001; 32: 1257-1263.
28. Dennery PA, Wong HE, Sridhar KJ, Rodgers PA, Sim JE, Spitz DR. Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts. Am J Physiol 1996; 271: L672-L679.
29. Kaminski N, Allard JD, Pittet JF, et al. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci USA 2000; 97: 1778-1783.
30. Tsuburai T, Suzuki M, Nagashima Y, et al. Adenovirus-mediated transfer and overexpression of heme oxygenase 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway. Hum Gene Ther 2002; 13: 1945-1960.
31. Atzori L, Chua F, Dunsmore SE, et al. Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol. Thorax 2004; 59: 217-223.
32. Suttner DM, Dennery PA. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J 1999; 13: 1800-1809.
33. Keane MP, Belperio JA, Burdick MD, Strieter RM. IL-12 attenuates bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2001; 281: L92-L97.
34. Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000; 6: 422-428.
35. Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002; 8: 240-246.
36. Dyck D, Otterbein LE, Choi AMK. Carbon monoxide attenuates lipopolysaccharide-induced cytokine expression of IL-6 and IL-1β. Am J Respir Crit Care Med 2000; 161: A664.
37. Pellacani A, Wiesel P, Sharma A, et al. Induction of heme oxygenase-1 during endotoxemia is downregulated by transforming growth factor-β1. Circ Res 1998; 83: 396-403.
38. Zayasu K, Sekizawa K, Okinaga S, Yamaya M, Ohrui T, Sasaki H. Increased carbon monoxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med 1997; 156: 1140-1143.
39. Zhou Z, Song R, Fattman CL, et al. Carbon monoxide suppresses bleomycin-induced lung fibrosis. Am J Pathol 2005; 166: 27-37.
40. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043-1046.
41. Dennery PA, McDonagh AF, Spitz DR, Rodgers PA, Stevenson DK. Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia. Free Radic Biol Med 1995; 19: 395-404.
42. Wang HD, Yamaya M, Okinaga S, et al. Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats. Am J Respir Crit Care Med 2002; 165: 406-411.