Modulation of the epileptic seizure threshold: Implications of biphasic dose responses

Critical Reviews in Toxicology

Volumn 38, Issue 6, 2008, Pages 543-556

  Calabrese, Edward J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Biphasic dose response; Epilepsy; Hormesis; Morphine; Seizure threshold

Indexed keywords

3 ALPHA DIOL; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 7 NITROINDAZOLE; CARBAMAZEPINE; CLONIDINE; DOPAMINE; DRUG METABOLITE; ESTRADIOL; FENTANYL; FINASTERIDE; GABOXADOL; LEVODOPA; LY 17 555; MORPHINE; MUSCIMOL; N (3 HYDROXYPHENETHYL) N (PHENETHYL)PROPYLAMINE; N NITROARGININE; N(G) NITROARGININE METHYL ESTER; NALTREXONE; NANTENINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE; PETHIDINE; PHENYTOIN; SHIGA TOXIN; SILDENAFIL; TESTOLACTONE; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VARDENAFIL; YOHIMBINE;

AGE; CHEMICAL STRUCTURE; CLINICAL EVALUATION; CLONIC SEIZURE; CONVULSION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENTIATION; DRUG RESPONSE; DRUG SCREENING; ENZYME INHIBITION; EPILEPSY; EXPERIMENTAL MODEL; HUMAN; LOW DRUG DOSE; MEASUREMENT; NONHUMAN; REVIEW; SCREENING TEST; SEIZURE; SEIZURE SUSCEPTIBILITY; SEIZURE THRESHOLD; SEX DIFFERENCE; SHIGELLA DYSENTERIAE;

ANIMALS; ANTICONVULSANTS; CONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MICE; RATS; SEIZURES;

ANIMALIA;

EID: 46949083071     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440802014261     Document Type: Review

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