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Volumn 617, Issue , 2008, Pages 23-40

Ovarian cancer: Linking genomics to new target discovery and molecular markers - The way ahead

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRCA1 PROTEIN; BRCA2 PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; K RAS PROTEIN; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PLATINUM DERIVATIVE; PROTEIN P53; PROTEIN PIK3CA; TAXANE DERIVATIVE; TRASTUZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN; TUMOR MARKER;

EID: 46749143830     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-69080-3_3     Document Type: Conference Paper
Times cited : (10)

References (50)
  • 1
    • 0037260139 scopus 로고    scopus 로고
    • Cancer statistics, 2003
    • Jemal A, et al. (2003) Cancer statistics, 2003. CA Cancer J Clin 53:5-26.
    • (2003) CA Cancer J Clin , vol.53 , pp. 5-26
    • Jemal, A.1
  • 2
    • 19744368302 scopus 로고    scopus 로고
    • Cancer of the ovary
    • Cannistra SA (2004) Cancer of the ovary. N Engl J Med 351:2519-2529.
    • (2004) N Engl J Med , vol.351 , pp. 2519-2529
    • Cannistra, S.A.1
  • 3
    • 33646561555 scopus 로고    scopus 로고
    • Ovarian cancer: Homeobox genes, autocrine/paracrine growth, and kinase signaling
    • Hennessy BT, Mills GB, et al. (2006) Ovarian cancer: Homeobox genes, autocrine/paracrine growth, and kinase signaling. Int J Biochem Cell Biol 38:1450-1456.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 1450-1456
    • Hennessy, B.T.1    Mills, G.B.2
  • 4
    • 0030707708 scopus 로고    scopus 로고
    • A conserved Hox axis in the mouse and human female reproductive system: Late establishment and persistent adult expression of the Hoxa cluster genes
    • Taylor HS, Vanden Heuvel GB, Igarashi P (1997) A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod 57:1338-1345.
    • (1997) Biol Reprod , vol.57 , pp. 1338-1345
    • Taylor, H.S.1    Vanden Heuvel, G.B.2    Igarashi, P.3
  • 5
    • 0037125582 scopus 로고    scopus 로고
    • Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: The ICON3 randomised trial
    • International Collaborative Ovarian Neoplasm Group
    • International Collaborative Ovarian Neoplasm Group (2002) Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: the ICON3 randomised trial. Lancet 360:505-515.
    • (2002) Lancet , vol.360 , pp. 505-515
  • 6
    • 0034307169 scopus 로고    scopus 로고
    • An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer
    • Suzuki S, Moore III DH, Ginzinger DG, et al. (2000) An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res 60:5382-5385.
    • (2000) Cancer Res , vol.60 , pp. 5382-5385
    • Suzuki, S.1    Moore III, D.H.2    Ginzinger, D.G.3
  • 7
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 17144382038 scopus 로고    scopus 로고
    • Frequent mutation of the PIK3CA gene in ovarian and breast cancers
    • Levine DA, Bogomolniy F, Yee CJ, et al. (2005) Frequent mutation of the PIK3CA gene in ovarian and breast cancers. Clin Cancer Res 11:2875-2878.
    • (2005) Clin Cancer Res , vol.11 , pp. 2875-2878
    • Levine, D.A.1    Bogomolniy, F.2    Yee, C.J.3
  • 9
    • 7444250290 scopus 로고    scopus 로고
    • Mutation of the PIK3CA gene in ovarian and breast cancer
    • Campbell IG, Russell SE, Choong DY, et al. (2004) Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64:7678-7681.
    • (2004) Cancer Res , vol.64 , pp. 7678-7681
    • Campbell, I.G.1    Russell, S.E.2    Choong, D.Y.3
  • 10
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • Shih IeM, Kurman RJ (2004) Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 164:1511-1518.
    • (2004) Am J Pathol , vol.164 , pp. 1511-1518
    • Shih, I.M.1    Kurman, R.J.2
  • 11
    • 0036178190 scopus 로고    scopus 로고
    • Current understanding of the epidemiology and clinical implications of BRCA1 and BRCA2 mutations for ovarian cancer
    • Narod SA, Boyd J (2002) Current understanding of the epidemiology and clinical implications of BRCA1 and BRCA2 mutations for ovarian cancer. Curr Opin Obstet Gynecol 14:19-26.
    • (2002) Curr Opin Obstet Gynecol , vol.14 , pp. 19-26
    • Narod, S.A.1    Boyd, J.2
  • 12
    • 20044381123 scopus 로고    scopus 로고
    • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
    • Stephens P, Edkins S, Davies H, et al. (2005) A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 37:590-592.
    • (2005) Nat Genet , vol.37 , pp. 590-592
    • Stephens, P.1    Edkins, S.2    Davies, H.3
  • 13
    • 33749993417 scopus 로고    scopus 로고
    • The Consensus Coding Sequences of Human Breast and Colorectal Cancers
    • Sjoblom T, Jones S, Wood LD, et al. (2006) The Consensus Coding Sequences of Human Breast and Colorectal Cancers. Science 314:268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3
  • 14
    • 0036463949 scopus 로고    scopus 로고
    • Induction of ovarian cancer by defined multiple genetic changes in a mouse model system
    • Orsulic S, Li Y, Soslow RA, et al. (2002). Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 1:53-62.
    • (2002) Cancer Cell , vol.1 , pp. 53-62
    • Orsulic, S.1    Li, Y.2    Soslow, R.A.3
  • 15
    • 13444269246 scopus 로고    scopus 로고
    • Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer
    • Dinulescu DM, Ince TA, Quade BJ, et al. (2005) Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med 11:63-70.
    • (2005) Nat Med , vol.11 , pp. 63-70
    • Dinulescu, D.M.1    Ince, T.A.2    Quade, B.J.3
  • 16
    • 33845621580 scopus 로고    scopus 로고
    • Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells
    • Yang G, Rosen DG, Mercado-Uribe I, et al. (2007) Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Carcinogenesis 28:174-182.
    • (2007) Carcinogenesis , vol.28 , pp. 174-182
    • Yang, G.1    Rosen, D.G.2    Mercado-Uribe, I.3
  • 17
    • 9744281915 scopus 로고    scopus 로고
    • Telomerase prolongs the lifespan of normal human ovarian surface epithelial cells without inducing neoplastic phenotype
    • Alvero AB, Fishman DA, Qumsiyeh MB, et al. (2004) Telomerase prolongs the lifespan of normal human ovarian surface epithelial cells without inducing neoplastic phenotype. J Soc Gynecol Investig 11:553-561.
    • (2004) J Soc Gynecol Investig , vol.11 , pp. 553-561
    • Alvero, A.B.1    Fishman, D.A.2    Qumsiyeh, M.B.3
  • 18
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: Biology, endocrinology and pathology
    • Auersperg N, Wong AS, Choi KC, et al. (2001) Ovarian surface epithelium: biology, endocrinology and pathology. Endocr Rev 22:255-288.
    • (2001) Endocr Rev , vol.22 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.2    Choi, K.C.3
  • 19
    • 0037627875 scopus 로고    scopus 로고
    • Why did p53 gene therapy fail in ovarian cancer?
    • Zeimet AG, Marth C (2003) Why did p53 gene therapy fail in ovarian cancer? Lancet Oncol 4:415-422.
    • (2003) Lancet Oncol , vol.4 , pp. 415-422
    • Zeimet, A.G.1    Marth, C.2
  • 21
    • 25444516265 scopus 로고    scopus 로고
    • Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma
    • Shih IeM, Sheu JJ, Santillan A, et al. (2005) Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. Proc Natl Acad Sci USA 102:14004-14009.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14004-14009
    • Shih, I.M.1    Sheu, J.J.2    Santillan, A.3
  • 22
    • 33646168471 scopus 로고    scopus 로고
    • Ovarian cancer: Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer (News and Commentary)
    • Hennessy BT, Nanjunden M, Cheng KW, Nolden L, Mills GB (2006) Ovarian cancer: identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer (News and Commentary). Eur J Hum Genet 14:381-383.
    • (2006) Eur J Hum Genet , vol.14 , pp. 381-383
    • Hennessy, B.T.1    Nanjunden, M.2    Cheng, K.W.3    Nolden, L.4    Mills, G.B.5
  • 23
    • 0035015609 scopus 로고    scopus 로고
    • A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization
    • Watanabe T, Imoto I, Kosugi Y, et al. (2001) A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization. Gynecol Oncol 81:172-177.
    • (2001) Gynecol Oncol , vol.81 , pp. 172-177
    • Watanabe, T.1    Imoto, I.2    Kosugi, Y.3
  • 24
    • 0032590011 scopus 로고    scopus 로고
    • PIK3CA is implicated as an oncogene in ovarian cancer
    • Shayesteh L, Lu Y, Kuo WL, et al. (1999) PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21:99-102.
    • (1999) Nat Genet , vol.21 , pp. 99-102
    • Shayesteh, L.1    Lu, Y.2    Kuo, W.L.3
  • 25
    • 9144271680 scopus 로고    scopus 로고
    • The Rab 25 small GTPase determines aggressiveness of ovarian and breast cancers
    • Cheng KW, Lahad JP, Kuo WL, et al. (2004) The Rab 25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med 10:1251-1256.
    • (2004) Nat Med , vol.10 , pp. 1251-1256
    • Cheng, K.W.1    Lahad, J.P.2    Kuo, W.L.3
  • 26
    • 24644490121 scopus 로고    scopus 로고
    • Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer
    • Eder A, Sui X, Rosen D, et al. (2005) Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci USA 102:12519-12524.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 12519-12524
    • Eder, A.1    Sui, X.2    Rosen, D.3
  • 27
    • 30444457408 scopus 로고    scopus 로고
    • Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas
    • Brown LA, Irving J, Parker R, et al. (2006) Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas. Gynecol Oncol 100:264-70.
    • (2006) Gynecol Oncol , vol.100 , pp. 264-270
    • Brown, L.A.1    Irving, J.2    Parker, R.3
  • 28
    • 10744233204 scopus 로고    scopus 로고
    • EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
    • Hughes-Davies L, Huntsman D, Ruas M, et al. (2003) EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 115:523-535.
    • (2003) Cell , vol.115 , pp. 523-535
    • Hughes-Davies, L.1    Huntsman, D.2    Ruas, M.3
  • 29
    • 0036635310 scopus 로고    scopus 로고
    • Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer
    • Anand N, Murthy S, Amann G, et al. (2002) Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nat Genet 31:301-305.
    • (2002) Nat Genet , vol.31 , pp. 301-305
    • Anand, N.1    Murthy, S.2    Amann, G.3
  • 30
    • 0041423391 scopus 로고    scopus 로고
    • Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
    • Schraml P, Schwerdtfeger G, Burkhalter F, et al. (2003) Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol 163:985-992.
    • (2003) Am J Pathol , vol.163 , pp. 985-992
    • Schraml, P.1    Schwerdtfeger, G.2    Burkhalter, F.3
  • 31
    • 33947274769 scopus 로고    scopus 로고
    • Multiple roles of the candidate oncogene znf217 in ovarian epithelial neoplastic progression
    • Li P, Maines-Bandiera S, Kuo WL, et al. (2007) Multiple roles of the candidate oncogene znf217 in ovarian epithelial neoplastic progression. Int J Cancer 120:1863-73.
    • (2007) Int J Cancer , vol.120 , pp. 1863-1873
    • Li, P.1    Maines-Bandiera, S.2    Kuo, W.L.3
  • 32
    • 20144386357 scopus 로고    scopus 로고
    • Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer
    • Kamikihara T, Arima T, Kato K, et al. (2005) Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer. Int J Cancer 115:690-700.
    • (2005) Int J Cancer , vol.115 , pp. 690-700
    • Kamikihara, T.1    Arima, T.2    Kato, K.3
  • 33
    • 0035099160 scopus 로고    scopus 로고
    • Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes
    • Strathdee G, Appleton K, Illand M, et al. (2001) Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. Am J Pathol 158:1121-1127.
    • (2001) Am J Pathol , vol.158 , pp. 1121-1127
    • Strathdee, G.1    Appleton, K.2    Illand, M.3
  • 34
    • 33646725688 scopus 로고    scopus 로고
    • Prognostic DNA methylation biomarkers in ovarian cancer
    • Wei SH, Balch C, Paik HH, et al. (2006) Prognostic DNA methylation biomarkers in ovarian cancer. Clin Cancer Res 12:2788-2794.
    • (2006) Clin Cancer Res , vol.12 , pp. 2788-2794
    • Wei, S.H.1    Balch, C.2    Paik, H.H.3
  • 35
    • 33745308428 scopus 로고    scopus 로고
    • Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: A retrospective analysis
    • Wright JD, Hagemann A, Rader JS, et al. (2006) Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: a retrospective analysis. Cancer 107:83-89.
    • (2006) Cancer , vol.107 , pp. 83-89
    • Wright, J.D.1    Hagemann, A.2    Rader, J.S.3
  • 36
    • 33748714310 scopus 로고    scopus 로고
    • Transcriptional profiling develops molecular signatures for ovarian tumors
    • Smith DI (2002) Transcriptional profiling develops molecular signatures for ovarian tumors. Cytometry 47:60-62.
    • (2002) Cytometry , vol.47 , pp. 60-62
    • Smith, D.I.1
  • 37
    • 34247338576 scopus 로고    scopus 로고
    • Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions
    • Nanjundan M, Zhang F, Schmandt R, Smith-McCune K, Mills GB (2007) Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions. Oncogene 26:2574-84.
    • (2007) Oncogene , vol.26 , pp. 2574-2584
    • Nanjundan, M.1    Zhang, F.2    Schmandt, R.3    Smith-McCune, K.4    Mills, G.B.5
  • 38
    • 0242406333 scopus 로고    scopus 로고
    • Utility of reverse phase protein arrays: Applications to signalling pathways and human body arrays
    • Charboneau L, Scott H, Chen T, et al. (2002) Utility of reverse phase protein arrays: applications to signalling pathways and human body arrays. Brief Funct Genomic Proteomic 1:305-315.
    • (2002) Brief Funct Genomic Proteomic , vol.1 , pp. 305-315
    • Charboneau, L.1    Scott, H.2    Chen, T.3
  • 39
    • 17844377553 scopus 로고    scopus 로고
    • Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma
    • Sheehan KM, Calvert VS, Kay EW, et al. (2005) Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma. Mol Cell Proteomics 4:346-355.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 346-355
    • Sheehan, K.M.1    Calvert, V.S.2    Kay, E.W.3
  • 40
    • 33750456480 scopus 로고    scopus 로고
    • Reverse phase protein array (RPPA): Validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoetic stem cells (HSC)
    • Tibes R, Qiu Y, Lu Y, et al. (2006) Reverse phase protein array (RPPA): validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoetic stem cells (HSC). Mol Cancer Ther 5:2512-21.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2512-2521
    • Tibes, R.1    Qiu, Y.2    Lu, Y.3
  • 41
    • 33644544070 scopus 로고    scopus 로고
    • Serum tumor markers in breast cancer: Are they of clinical value?
    • Duffy MJ (2006) Serum tumor markers in breast cancer: are they of clinical value? Clin Chem 52:345-351.
    • (2006) Clin Chem , vol.52 , pp. 345-351
    • Duffy, M.J.1
  • 42
    • 28444478097 scopus 로고    scopus 로고
    • Characterization of serum biomarkers for detection of early stage ovarian cancer
    • Kozak KR, Su F, Whitelegge JP, et al. (2005) Characterization of serum biomarkers for detection of early stage ovarian cancer. Proteomics 5:4589-4596.
    • (2005) Proteomics , vol.5 , pp. 4589-4596
    • Kozak, K.R.1    Su, F.2    Whitelegge, J.P.3
  • 43
    • 0242352423 scopus 로고    scopus 로고
    • Preoperative detection of peripherally circulating cancer cells and its prognostic significance in ovarian cancer
    • Judson PL, Geller MA, Bliss RL, et al. (2003) Preoperative detection of peripherally circulating cancer cells and its prognostic significance in ovarian cancer. Gynecol Oncol 91:389-394.
    • (2003) Gynecol Oncol , vol.91 , pp. 389-394
    • Judson, P.L.1    Geller, M.A.2    Bliss, R.L.3
  • 44
    • 24344497920 scopus 로고    scopus 로고
    • Specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer
    • Swisher EM, Wollan M, Mahtani SM, et al. (2005) Specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer. Am J Obstet Gynecol 193:662-667.
    • (2005) Am J Obstet Gynecol , vol.193 , pp. 662-667
    • Swisher, E.M.1    Wollan, M.2    Mahtani, S.M.3
  • 45
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M, Budd GT, Ellis MJ, et al. (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. New Engl J Med 351:781-791.
    • (2004) New Engl J Med , vol.351 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3
  • 46
    • 18844450688 scopus 로고    scopus 로고
    • Circulating tumor cells in breast cancer: Correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity
    • Muller V, Stahmann N, Riethdorf S, et al. (2005) Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Can Res 11:3678-3685.
    • (2005) Clin Can Res , vol.11 , pp. 3678-3685
    • Muller, V.1    Stahmann, N.2    Riethdorf, S.3
  • 48
    • 27144497798 scopus 로고    scopus 로고
    • From XML to RDF: How semantic web technologies will change the design of 'omic' standards
    • Wang X, Gorlitsky R, Almeida JS (2005) From XML to RDF: how semantic web technologies will change the design of 'omic' standards. Nat Biotechnol 23:1099-1103.
    • (2005) Nat Biotechnol , vol.23 , pp. 1099-1103
    • Wang, X.1    Gorlitsky, R.2    Almeida, J.S.3
  • 50
    • 18344373769 scopus 로고    scopus 로고
    • Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
    • Cheng W, Liu J, Yoshida H, et al. (2005) Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 11:531-537.
    • (2005) Nat Med , vol.11 , pp. 531-537
    • Cheng, W.1    Liu, J.2    Yoshida, H.3


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