Diabetic osteopathy and the IGF system in the Goto-Kakizaki rat

Growth Hormone and IGF Research

Volumn 18, Issue 5, 2008, Pages 404-411

  Ahmad, Tashfeen ^a,b   Ugarph Morawski, Anna ^a   Lewitt, Moira S ^a   Li, Jian ^a   Sääf, Maria ^a   Brismar, Kerstin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

Author keywords

Bone mineral density; Diabetes mellitus type 2; Goto Kakizaki rat; Insulin like growth factor 1; Insulin like growth factor binding protein 1; Insulin like growth factor binding protein 4

Indexed keywords

INSULIN; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKLE; ARTICLE; BONE DENSITY; BONE EROSION; BONE RADIOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DIABETIC OSTEODYSTROPHY; DIAPHYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; GOTO KAKIZAKI RAT; HUMERUS; IMMUNOASSAY; METAPHYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSTEODYSTROPHY; OSTEOPENIA; PERIOSTEUM; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TIBIA; VERTEBRA; WISTAR RAT;

ANIMALS; BONE AND BONES; BONE DISEASES, METABOLIC; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DIAPHYSES; FEMALE; FRACTURES, BONE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; INSULIN-LIKE GROWTH FACTOR I; RATS; RATS, WISTAR;

EID: 46749124702     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2008.02.003     Document Type: Article

References (35)

1. Ahmad T., Ohlsson C., Ostenson C.G., and Kreicbergs A. Peripheral quantitative computed tomography for the detection of diabetic osteopathy: a study in the Goto-Kakizaki rat. Invest. Radiol. 38 (2003) 171-176
2. Ahmad T., Ohlsson C., Saaf M., Ostenson C.G., and Kreicbergs A. Skeletal changes in type-2 diabetic Goto-Kakizaki rats. J. Endocrinol. 178 (2003) 111-116
3. Ahmed M., Bjurholm A., Srinivasan G.R., Theodorsson E., and Kreicbergs A. Extraction of neuropeptides from joint tissue for quantitation by radioimmunoassay. A study in the rat. Peptides 15 (1994) 317-322
4. Ahmed M., Srinivasan G.R., Theodorsson E., Bjurholm A., and Kreicbergs A. Extraction and quantitation of neuropeptides in bone by radioimmunoassay. Regul. Pept. 51 (1994) 179-188
5. Bach L.A., and Rechler M.M. Insulin-like growth factors and diabetes. Diabetes Metab. Rev. 8 (1992) 229-257
6. Bang P., Eriksson U., Sara V., Wivall I.L., and Hall K. Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinol. (Copenh) 124 (1991) 620-629
7. Chelius D., and Spencer E.M. A new radioimmunoassay to measure rat insulin-like growth factor binding protein-4 (IGFBP-4) in serum, wound fluid and conditioned media. Growth Horm. IGF Res. 11 (2001) 49-57
8. Ekman B., Nystrom F., and Arnqvist H.J. Circulating IGF-I concentrations are low and not correlated to glycaemic control in adults with type 1 diabetes. Eur. J. Endocrinol. 143 (2000) 505-510
9. Fang Y., Wang Z.Y., Mao Y., Xin H.T., Ren G.L., and Bai X.F. Effects of insulin-like growth factor I on the development of osteoblasts in hyperglycemia. Diabetes Res. Clin. Pract. 73 (2006) 95-97
10. Gamero P., Sornay-Rendu E., and Delmas P.D. Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. Lancet 355 (2000) 898-899
11. Goto Y., Kakizaki M., and Masaki N. Production of spontaneous diabetic rats by repetition of selective breeding. Tohoku J. Exp. Med. 119 (1976) 85-90
12. Isaksson O.G., Ohlsson C., Bengtsson B.A., and Johannsson G. GH and bone - experimental and clinical studies. Endocr. J. 47 Suppl (2000) S9-S16
13. Jeffcoate W., Lima J., and Nobrega L. The charcot foot. Diabet. Med. 17 (2000) 253-258
14. Jehle P.M., Jehle D.R., Mohan S., and Bohm B.O. Serum levels of insulin-like growth factor system components and relationship to bone metabolism in type 1 and type 2 diabetes mellitus patients. J. Endocrinol. 159 (1998) 297-306
15. Jehle P.M., Schulten K., Schulz W., Jehle D.R., Stracke S., Manfras B., Boehm B.O., Baylink D.J., and Mohan S. Serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 to -6 and their relationship to bone metabolism in osteoporosis patients. Eur. J. Int. Med. 14 (2003) 32-38
16. Kanazawa I., Yamaguchi T., Yamamoto M., Yamauchi M., Yano S., and Sugimoto T. Serum insulin-like growth factor-I level is associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes mellitus. Osteoporosis Int. 18 (2007) 1675-1681
17. Lagumdzija A., Ou G., Petersson M., Bucht E., Gonon A., and Pernow Y. Inhibited anabolic effect of insulin-like growth factor-I on stromal bone marrow cells in endothelial nitric oxide synthase-knockout mice. Acta Physiol. Scand. 182 (2004) 29-35
18. Lewitt M.S. Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 282 (2001) 1126-1131
19. McCarthy T.L., and Centrella M. Local IGF-I expression and bone formation. Growth Horm. IGF Res. Acta Endocrinol. (Copenh) 11 (2001) 213-219
20. Miao J., Brismar K., Nyren O., Ugarph-Morawski A., and Ye W. Elevated hip fracture risk in type 1 diabetic patients: a population-based cohort study in Sweden. Diabetes Care 28 (2005) 2850-2855
21. Miyakoshi N., Qin X., Kasukawa Y., Richman C., Srivastava A.K., Baylink D.J., and Mohan S. Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism. Endocrinology 142 (2001) 2641-2648
22. Miyakoshi N., Richman C., Kasukawa Y., Linkhart T.A., Baylink D.J., and Mohan S. Evidence that IGF-binding protein-5 functions as a growth factor. J. Clin. Invest. 107 (2001) 73-81
23. Mohan S., and Baylink D.J. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J. Endocrinol. 175 (2002) 19-31
24. Mohan S., Nakao Y., Honda Y., Landale E., Leser U., Dony C., Lang K., and Baylink D.J. Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. J. Biol. Chem. 270 (1995) 20424-20431
25. Ostenson C.G. The Goto-Kakizaki rat. In: Shafrir E. (Ed). Animal Models in Diabetes: A Primer (Frontiers in Animal Diabetes Research) (2001), Harwood Academic Publishers, Amsterdam 197-211
26. Schwartz A.V., Sellmeyer D.E., Ensrud K.E., Cauley J.A., Tabor H.K., Schreiner P.J., Jamal S.A., Black D.M., and Cummings S.R. Older women with diabetes have an increased risk of fracture: a prospective study. J. Clin. Endocrinol. Metab. 86 (2001) 32-38
27. Seeman E. Clinical review 137: sexual dimorphism in skeletal size, density, and strength. J. Clin. Endocrinol. Metab. 86 (2001) 4576-4584
28. Seeman E. Growth in bone mass and size - are racial and gender differences in bone mineral density more apparent than real?. J. Clin. Endocrinol. Metab. 83 (1998) 1414-1419
29. Shimasaki S., and Ling N. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6). Prog. Growth Factor Res. 3 (1991) 243-266
30. Ugarph A., Rahn T., and Brismar K. Osteopenia in diabetes mellitus: correlation to IGF-I, IGFBP-3, IGFBP-4 and IGFBP-5. In abstracts of the 37th annual meeting of the European association for the study of diabetes (EASD), Glasgow, UK. Diabetologia 44 (2001) A1-A35
31. Woods K.A., Camacho-Hubner C., Barter D., Clark A.J., and Savage M.O. Insulin-like growth factor I gene deletion causing intrauterine growth retardation and severe short stature. Acta Paediatr. Suppl. 423 (1997) 39-45
32. Yakar S., Rosen C.J., Beamer W.G., Ackert-Bicknell C.L., Wu Y., Liu J.L., Ooi G.T., Setser J., Frystyk J., Boisclair Y.R., and LeRoith D. Circulating levels of IGF-1 directly regulate bone growth and density. J. Clin. Invest. 110 (2002) 771-781
33. Young M.J., Marshall A., Adams J.E., Selby P.L., and Boulton A.J. Osteopenia, neurological dysfunction, and the development of Charcot neuroarthropathy. Diabetes Care 18 (1995) 34-38
34. Zhang M., Faugere M.C., Malluche H., Rosen C.J., Chernausek S.D., and Clemens T.L. Paracrine overexpression of IGFBP-4 in osteoblasts of transgenic mice decreases bone turnover and causes global growth retardation. J. Bone Miner. Res. 18 (2003) 836-843
35. Zhang M., Xuan S., Bouxsein M.L., von Stechow D., Akeno N., Faugere M.C., Malluche H., Zhao G., Rosen C.J., Efstratiadis A., and Clemens T.L. Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J. Biol. Chem. 277 (2002) 44005-44012