Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism

Endocrinology

Volumn 142, Issue 6, 2001, Pages 2641-2648

  Miyakoshi, Naohisa ^a   Qin, Xuezhong ^a,b   Kasukawa, Yuji ^a   Richman, Charmaine ^a   Srivastava, Apurva K ^a,b   Baylink, David J ^a,b   Mohan, Subburaman ^a,b,c  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b Department of Medicine ^*  (United States)

^c LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; OSTEOCALCIN; PROTEINASE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 4;

ANIMAL CELL; ARTICLE; BIOAVAILABILITY; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME MECHANISM; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION;

EID: 0035000651     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.6.8192     Document Type: Article

References (33)

1. 1. Rosen CJ, Donahue LR, Hunter SJ 1994 Insulin-like growth factors and bone: the osteoporosis connection. Proc Soc Exp Biol Med 206:83-102
2. 2. McCarthy TL, Centrella M, Canalis E 1989 Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures. Endocrinology 124:301-309
3. 3. Schoenle E, Zapf J, Hauri C, Steiner T, Froesch ER 1985 Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats. Acta Endocrinol (Copenh) 108:167-174
4. 4. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A 1993 Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59-72
5. 5. Woods KA, Camacho-Hubner C, Savage MO, Clark AJ 1996 Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N Engl J Med 335:1363-1367
6. 6. Baylink DJ, Finkelman RD, Mohan S 1993 Growth factors to stimulate bone formation. J Bone Miner Res 8(Suppl 2):S565-S572
7. 7. Spencer EM, Liu CC, Si EC, Howard GA 1991 In vivo actions of insulin-like growth factor-I (IGF-I) on bone formation and resorption in rats. Bone 12:21-26
8. 8. Mohan S, Baylink DJ 1996 Insulin-like growth factor system components and the coupling of bone formation to resorption. Horm Res 45:59-62
9. 9. Ohlsson C, Bengtsson BA, Isaksson OG, Andreassen TT, Slootweg MC 1998 Growth hormone and bone. Endocr Rev 19:55-79
10. 10. Rajaram S, Baylink DJ, Mohan S 1997 Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev 18:801-831
11. 11. Mohan S, Nakao Y, Honda Y, Landale E, Leser U, Dony C, Lang K, Baylink DJ 1995 Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. J Biol Chem 270:20424-20431
12. 12. Schiltz PM, Mohan S, Baylink DJ 1993 Insulin-like growth factor binding protein-4 inhibits both basal and IGF-mediated chick pelvic cartilage growth in vitro. J Bone Miner Res 8:391-396
13. 13. Mohan S, Bautista CM, Wergedal J, Baylink DJ 1989 Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action. Proc Natl Acad Sci USA 86:8338-8342
14. 14. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
15. 15. Qin X, Strong DD, Baylink DJ, Mohan S 1998 Structure-function analysis of the human insulin-like growth factor binding protein-4. J Biol Chem 273:23509-23516
16. 16. Miyakoshi N, Richman C, Qin X, Baylink DJ, Mohan S 1999 Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice. Endocrinology 140:5719-5728
17. 17. Qin X, Byun D, Strong DD, Baylink DJ, Mohan S 1999 Studies on the role of human insulin-like growth factor-II (IGF-II)-dependent IGF binding protein (hIGFBP)-4 protease in human osteoblasts using protease-resistant IGFBP-4 analogs. J Bone Miner Res 14:2079-2088
18. 18. Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J, Jr., Chien KR, Powell-Braxton L 1996 Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. J Clin Invest 98:2648-2655
19. 19. Honda Y, Landale EC, Strong DD, Baylink DJ, Mohan S 1996 Recombinant synthesis of insulin-like growth factor-binding protein-4 (IGFBP-4): development, validation, and application of a radioimmunoassay for IGFBP-4 in human serum and other biological fluids. J Clin Endocrinol Metab 81:1389-1396
20. 20. Dimai HP, Linkhart TA, Linkhart SG, Donahue LR, Beamer WG, Rosen CJ, Farley JR, Baylink DJ 1998 Alkaline phosphatase levels and osteoprogenitor cell numbers suggest bone formation may contribute to peak bone density differences between two inbred strains of mice. Bone 22:211-216
21. 21. Linkhart TA, Linkhart SG, Kodama Y, Farley JR, Dimai HP, Wright KR, Wergedal JE, Sheng M, Beamer WG, Donahue LR, Rosen CJ, Baylink DJ 1999 Osteoclast formation in bone marrow cultures from two inbred strains of mice with different bone densities. J Bone Miner Res 14:39-46
22. 22. Noda M, Camilliere JJ 1989 In vivo stimulation of bone formation by transforming growth factor-β. Endocrinology 124:2991-2994
23. 23. Marcelli C, Yates AJ, Mundy GR 1990 In vivo effects of human recombinant transforming growth factor beta on bone turnover in normal mice. J Bone Miner Res 5:1087-1096
24. 24. Frystyk J, Gronbaek H, Skjaerbaek C, Flyvbjerg A, Orskov H, Baxter RC 1998 Developmental changes in serum levels of free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit in rats. Endocrinology 139:4286-4292
25. 18 Sep-Pak separation. J Clin Endocrinol Metab 80:637-647
26. 26. Srivastava AK, Castillo G, Wergedal JE, Mohan S, Baylink DJ 2000 Development and application of a synthetic peptide-based osteocalcin assay for the measurement of bone formation in mouse serum. Calcif Tissue Int 67:255-259
27. 27. Farley JR, Hall SL, Tanner MA, Wergedal JE 1994 Specific activity of skeletal alkaline phosphatase in human osteoblast-line cells regulated by phosphate, phosphate esters, and phosphate analogs and release of alkaline phosphatase activity inversely regulated by calcium. J Bone Miner Res 9:497-508
28. 3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts. Endocrinology 129:3139-3146
29. 29. Adams S, Moore J, Chu S, Bagi C, DeLeon L, Liu C, Schmidt D, Sommer A 1995 Pharmacokinetics and bioavailability of rhIGF-I/IGFBP-3 in the rat and monkey. Prog Growth Factor Res 6:347-356
30. 30. Hasegawa T, Hasegawa Y, Takada M, Tsuchiya Y 1995 The free form of insulin-like growth factor I increases in circulation during normal human pregnancy. J Clin Endocrinol Metab 80:3284-3286
31. rd, Conover CA 1999 The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci USA 96:3149-3153
32. 32. Conover CA, Oxvig C, Overgaard MT, Christiansen M, Giudice LC 1999 Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A. J Clin Endocrinol Metab 84:4742-4745
33. 33. Byun D, Mohan S, Yoo M, Sexton C, Baylink DJ, Qin X 2001 Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFPB-4 in vitro. J Clin Endocrinol Metab 86:847-854