Paracrine Overexpression of IGFBP-4 in Osteoblasts of Transgenic Mice Decreases Bone Turnover and Causes Global Growth Retardation

Journal of Bone and Mineral Research

Volumn 18, Issue 5, 2003, Pages 836-843

  Zhang, Mei ^a   Faugere, Marie Claude ^b   Malluche, Hartmut ^b   Rosen, Clifford J ^c   Chernausek, Steven D ^d   Clemens, Thomas L ^a,e  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c St Joseph's Hospital Bangor   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e Vontz Center for Molecular Studies   (United States)

Author keywords

Bone histomorphometry; Insulin like growth factor binding proteins; Insulin like growth factor 1; Osteoblasts; Transgenic mice

Indexed keywords

OSTEOCALCIN; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C;

ALLOMETRY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BONE; BONE GROWTH; BONE TURNOVER; CALVARIA; CANCELLOUS BONE; CONTROLLED STUDY; FEMUR; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; GROWTH PLATE; GROWTH RETARDATION; MICROENVIRONMENT; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCALCIN BP4 CHIMERIC GENE; PARACRINE SIGNALING; POSTNATAL GROWTH; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE HISTOMORPHOMETRY; TRANSGENE; TRANSGENIC ANIMAL; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BONE DEVELOPMENT; BONE REMODELING; DNA PRIMERS; GROWTH; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; MICE; MICE, TRANSGENIC; OSTEOCALCIN; PROMOTER REGIONS (GENETICS); TRANSGENES;

EID: 0142027567     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2003.18.5.836     Document Type: Article

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