Insulin is a dominant suppressor of sterol 12α-hydroxylase P450 (CYP8B) expression in rat liver: Possible role of insulin in circadian rhythm of CYP8B

Journal of Biochemistry

Volumn 127, Issue 1, 2000, Pages 57-64

  Ishida, Hiroko ^a,b   Yamashita, Chika ^b   Kuruta, Yoshihiro ^a   Yoshida, Yuzo ^b   Noshiro, Mitsuhide ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Bile acid; Cytochrome P450; FXR; Insulin; Sterol 12 hydroxylase

Indexed keywords

CYTOCHROME P450; INSULIN; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; HORMONAL REGULATION; HORMONE ACTION; LIVER; MALE; NONHUMAN; OSCILLATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 0033965228     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022584     Document Type: Article

References (59)

1. Okuda, K., Ogishima, T., and Noshiro, M. (1993) Cholesterol 7α-hydroxylase and 12α-hydroxylase in Cytochrome P450 (Schenkman, J.B. and Greim, H., eds.) Vol. 105, pp. 599-610, Springer Verlag, Berlin
2. Einarsson, K. (1968) On the properties of the 12α-hydroxylase in cholic acid biosynthesis. Bile acids and steroids. 198. Eur. J. Biochem. 5, 101-108
3. Uchida, K., Takase, H., Kadowaki, M., Nomura, Y., Matsubara, T., and Takeuchi, N. (1979) Altered bile acid metabolism in alloxan diabetic rats. Jpn. J. Pharmacol. 29, 553-562
4. Uchida, K., Nomura, Y., and Takeuchi, N. (1980) Effects of cholic acid, chenodeoxycholic acid, and their related bile acids on cholesterol, phospholipid, and bile acid levels in serum, liver, bile, and feces of rats. J. Biochem. 87, 187-194
5. Wang, D.Q., Lammert, F., Cohen, D.E., Paigen, B., and Carey, M.C. (1999) Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis. Am. J. Physiol. 276, G751-760
6. van de Heijning, B.J., Stolk, M.F., van Erpecum, K.J., Renooij, W., Groen, A.K., and vanBerge Henegouwen, G.P. (1994) Bile salt-induced cholesterol crystal formation from model bile vesicles: a time course study. J. Lipid Res. 35, 1002-1011
7. Shaw, R. and Elliott, W.H. (1979) Competitive inhibitors of rabbit hepatic microsomal 12α-steroid hydroxylase. J. Biol. Chem. 254, 7177-7182
8. Attili, A.F., Capocaccia, R., Carulli, N., Festi, D., Roda, E., Barbara, L., Capocaccia, L., Menotti, A., Okolicsanyi, L., Ricci, G., Lalloni, L., Mariotti, S., Sama, C., and Scafato, E. (1997) Factors associated with gallstone disease in the MICOL experience. Multicenter Italian Study on Epidemiology of Cholelithiasis. Hepatology 26, 809-818
9. Ishida, H., Noshiro, M., Okuda, K., and Coon, M.J. (1992) Purification and characterization of 7α-hydroxy-4-cholesten-3-one 12α-hydroxylase. J. Biol. Chem. 267, 21319-21323
10. Ishida, H., Kuruta, Y., Gotoh, O., Yamashita, C., Yoshida, Y., and Noshiro, M. (1999) Structure, evolution, and liver specific expression of rat sterol 12α-hydroxylase P450 (CYP8B). J. Biochem. 126, 19-25
11. Noshiro, M. and Omura, T. (1978) Immunochemical study on the electron pathway from NADH to cytochrome P-450 of liver microsomes. J. Biochem. 83, 61-77
12. Cox, R.A. (1968) The use of guanidium chloride in the isolation of nucleic acids. Methods Enzymol. 12B, 120-129
13. Aviv, H. and Leder, P. (1972) Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc. Natl. Acad. Sci. USA 69, 1408-1412
14. Haggerty, D.F., Young, P.L., Popjak, G., and Carnes, W.H. (1973) Phenylalanine hydroxylase in cultured hepatoxytes. I. Hormonal control of enzyme levels. J. Biol. Chem. 248, 223-232
15. Smale, G. and Sasse, J. (1992) RNA isolation from cartilage using density gradient centrifugation in cesium trifluoroacetate: an RNA preparation technique effective in the presence of high proteoglycan content. Anal. Biochem. 203, 352-356
16. Noshiro, M., Nishimoto, M., and Okuda, K. (1990) Rat liver cholesterol 7α-hydroxylase. Pretranslational regulation for circadian rhythm. J. Biol. Chem. 265, 10036-10041
17. Thomas, P.S. (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA 77, 5201-5205
18. Noshiro, M., Ishida, H., Hayashi, S., and Okuda, K. (1985) Assays for cholesterol 7α-hydroxylase and 12α-hydroxylase using high performance liquid chromatography. Steroids 45, 539-550
19. Ogishima, T. and Okuda, K. (1986) An improved method for assay of cholesterol 7α-hydroxylase activity. Anal. Biochem. 158, 228-232
20. Rakieten, N., Rakieten, M.L., and Nadkarni, M.V. (1963) Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother. 29, 91-98
21. Mithieux, G., Vidal, H., Zitoun, C., Bruni, N., Daniele, N., and Minassian, C. (1996) Glucose-6-phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats. Diabetes 45, 891-896
22. Argaud, D., Zhang, Q., Pan, W., Maitra, S., Pilkis, S.J., and Lange, A.J. (1996) Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: gene structure and 5′-flanking sequence. Diabetes 45, 1563-1571
23. Streeper, R.S., Svitek, C.A., Chapman, S., Greenbaum, L.E., Taub, R., and O'Brien, R.M. (1997) A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin. J. Biol. Chem. 272, 11698-11701
24. Princen, H.M.G., Post, S.M., and Twisk, J. (1997) Regulation of bile acid biosynthesis. Current Pharmaceutical Design 3, 59-84
25. Ip, M.M., Ip, C., Tepperman, H.M., and Tepperman, J. (1977) Effect of adaptation to meal-feeding on insulin, glucagon and the cyclic nucleotide-protein kinase system in rats. J. Nutr. 107, 746-757
26. Martin, R.J., Wangsness, P.J., and Gahagan, J.H. (1978) Diurnal changes in serum metabolites and hormones in lean and obese Zucker rats. Harm. Metab. Res. 10, 187-192
27. Van Cauter, E., Shapiro, E.T., Tillil, H., and Polonsky, K.S. (1992) Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm. Am. J. Physiol. 262, E467-475
28. Ahlersova, E., Ahlers, I., and Smajda, B. (1992) Influence of light regimen and time of year on circadian oscillations of insulin and corticosterone in rats. Physiol. Res. 41, 307-314
29. Lange, A.J., Argaud, D., el Maghrabi, M.R., Pan, W., Maitra, S.R., and Pilkis, S.J. (1994) Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Biochem. Biophys. Res. Commun. 201, 302-309
30. Unterman, T., Oehler, D., Ngyuen, H., Sengupta, P., and Lacson, R. (1995) A novel DNA/protein complex interacts with the insulin-like growth factor binding protein-1 (IGFBP-1) insulin response sequence and is required for maximal effects of insulin and glucocorticoids on promoter function. Prog. Growth Factor Res. 6, 119-129
31. O'Brien, R.M., Noisin, E.L., Suwanichkul, A., Yamasaki, T., Lucas, P.C., Wang, J.C., Powell, D.R., and Granner, D.K. (1995) Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes. Mol. Cell. Biol. 15, 1747-1758
32. Streeper, R.S., Eaton, E.M., Ebert, D.H., Chapman, S.C., Svitek, C.A., and O'Brien, R.M. (1998) Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription. Proc. Natl. Acad. Sci. USA 95, 9208-9213
33. Gafvels, M., Olin, M., Chowdhary, B., Raudsepp, T., Andersson, U., Persson, B., Jansson, M., Björkhem, I., and Eggertsen, G. (1999) Structure and chromosomal assignment of the sterol 12α-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics 56, 184-196
34. Lawrence, J.C., Jr. (1992) Signal transduction and protein phosphorylation in the regulation of cellular metabolism by insulin. Annu. Rev. Physiol. 54, 177-193
35. Akiyoshi, T., Uchida, K., Takase, H., Nomura, Y., and Takeuchi, N. (1986) Cholesterol gallstones in alloxan-diabetic mice. J. Lipid Res. 27, 915-924
36. Bennion, L.J. and Grundy, S.M. (1977) Effects of diabetes mellitus on cholesterol metabolism in man. N. Engl. J. Med. 296, 1365-1371
37. Nervi, F.O., Severin, C.H., and Valdivieso, V.D. (1978) Bile acid pool changes and regulation of cholate synthesis in experimental diabetes. Biochim. Biophys. Acta 529, 212-223
38. Villanueva, G.R., Herreros, M., Perez Barriocanal, F., Bolanos, J.P., Bravo, P., and Marin, J.J. (1990) Enhancement of bile acid-induced biliary lipid secretion by streptozotocin in rats: role of insulin deficiency. J. Lab. Clin. Med. 115, 441-448
39. Botham, K.M. and Boyd, G.S. (1983) The effect of dibutyryladenosine 3′,5′-monophosphate on the synthesis of bile salts in isolated hepatocytes from rat. Eur. J. Biochem. 136, 313-319
40. Hylemon, P.B., Gurley, E.C., Stravitz, R.T., Litz, J.S., Pandak, W.M., Chiang, J.Y., and Vlahcevic, Z.R. (1992) Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures. J. Biol. Chem. 267, 16866-16871
41. Twisk, J., Hoekman, M.F., Lehmann, E.M., Meijer, P., Mager, W.H., and Princen, H.M. (1995) Insulin suppresses bile acid synthesis in cultured rat hepatocytes by down-regulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase gene transcription. Hepatology 21, 501-510
42. Eggertsen, G., Olin, M., Andersson, U., Ishida, H., Kubota, S., Hellman, U., Okuda, K.I., and Björkhem, I. (1996) Molecular cloning and expression of rabbit sterol 12α-hydroxylase. J. Biol. Chem. 271, 32269-32275
43. Szepesi, B., Berdanier, C.D., Diachenko, S.K., and Moser, P.B. (1971) Effect of length of starvation, refeeding, and 8-azaguanine on serum insulin and NADP-linked dehydrogenases of rat liver. J. Nutr. 101, 1147-1151
44. Tiedgen, M. and Seitz, H.J. (1980) Dietary control of circadian variations in serum insulin, glucagon and hepatic cyclic AMP. J. Nutr. 110, 876-882
45. Mlekusch, W., Paletta, B., Truppe, W., Paschke, E., and Grimus, R. (1981) Plasma concentrations of glucose, corticosterone, glucagon and insulin and liver content of metabolic substrates and enzymes during starvation and additional hypoxia in the rat. Horm. Metab. Res. 13, 612-614
46. Van Cauter, E., Blackman, J.D., Roland, D., Spire, J.P., Refet-off, S., and Polonsky, K.S. (1991) Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J. Clin. Invest. 88, 934-942
47. Andersson, U., Yang, Y.Z. Björkhem, I., Einarsson, C., Eggertsen, G., and Gåfvels, M. (1999) Thyroid hormone suppresses hepatic sterol 12α-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: Failure to define known thyroid hormone response elements in the gene. Biochim. Biophys. Acta 1438, 167-174
48. Mayer, D. (1976) The circadian rhythm of synthesis and catabolism of cholesterol. Arch. Toxicol. 36, 267-276
49. Lavery, D.J. and Schibler, U. (1993) Circadian transcription of the cholesterol 7α-hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev. 7, 1871-1884
50. Lee, Y.H., Alberta, J.A., Gonzalez, F.J., and Waxman, D.J. (1994) Multiple, functional DBP sites on the promoter of the cholesterol 7α-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression. J. Biol. Chem. 269, 14681-14689
51. Berkowitz, C.M., Shen, C.S., Bilir, B.M., Guibert, E., and Gumucio, J.J. (1995) Different hepatocytes express the cholesterol 7α-hydroxylase gene during its circadian modulation in vivo. Hepatology 21, 1658-1667
52. Wuarin, J., Falvey, E., Lavery, D., Talbot, D., Schmidt, E., Ossipow, V., Fonjallaz, P., and Schibler, U. (1992) The role of the transcriptional activator protein DBP in circadian liver gene expression. J. Cell Sci. Suppl. 16, 123-127
53. Makishima, M., Okamoto, A.Y., Repa, J.J., Tu, H., Learned, R.M., Luk, A., Hull, M.V., Lustig, K.D., Mangelsdorf, D.J., and Shan, B. (1999) Identification of a nuclear receptor for bile acids. Science 284, 1362-1365
54. Parks, D.J., Blanchard, S.G., Bledsoe, R.K., Chandra, G., Consler, T.G., Kliewer, S.A., Stimmel, J.B., Willson, T.M., Zavacki, A.M., Moore, D.D., and Lehmann, J.M. (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284, 1365-1368
55. Wang, H., Chen, J., Hollister, K., Sowers, L.C., and Forman, B.M. (1999) Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 3, 543-553
56. Vonk, R.J., van Doorn, A.B., and Strubbe, J.H. (1978) Bile secretion and bile composition in the freely moving, unanaesthetized rat with a permanent biliary drainage: influence of food intake on bile flow. Clin. Sci. Mol. Med. 55, 253-259
57. Gagliardino, J.J., Pessacq, M.T., Hernandez, R.E., and Rebolledo, O.R. (1978) Circadian variations in serum glucagon and hepatic glycogen and cyclic amp concentrations. J. Endocrinol. 78, 297-298
58. Band, G.C. and Jones, C.T. (1980) Functional activation by glucagon of glucose 6-phosphatase and gluconeogenesis in the perfused liver of the fetal guinea pig. FEBS Lett. 119, 190-194
59. Tashima, Y., Mizunuma, H., Shima, H., Kobayashi, R., Tanaka, S., Maeda, N., and Kumegawa, M. (1984) Induction of fructose 1,6-bisphosphatase and glucose 6-phosphatase by dibutyryl cyclic adenosine monophosphate in fetal mouse liver. J. Biochem. 96, 805-813