Suppression of cytotoxic and proliferative xenogeneic T-cell responses by transgenic expression of indoleamine 2,3-dioxygenase

Immunology and Cell Biology

Volumn 86, Issue 5, 2008, Pages 460-465

  Wee, Janet Lye Keng ^a   Christiansen, Dale ^a   Li, Yu Qin ^a   Boyle, William ^a   Sandrin, Mauro S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Indoleamine 2,3 dioxygenase; Suppression; T lymphocytes; Xenotransplantation

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE;

ANIMAL CELL; ARTICLE; BAGG ALBINO MOUSE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; ENDOTHELIUM CELL; ENZYME ACTIVITY; GRAFT SURVIVAL; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SCID MOUSE; SPLEEN CELL; SWINE; T LYMPHOCYTE; XENOGRAFT;

ADAPTATION, BIOLOGICAL; ANIMALS; CELL PROLIFERATION; CELL TRANSPLANTATION; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOLOGIC MEMORY; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MICE; MICE, TRANSGENIC; RECOMBINATION, GENETIC; SPLEEN; SWINE; T-LYMPHOCYTES;

MUS; SUIDAE;

EID: 46749090871     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2008.8     Document Type: Article

References (27)

1. 2 incorporation by a heme-containing dioxygenase. Proc Natl Acad Sci USA 2006; 103: 2611-2616.
2. King NJ, Thomas SR. Molecules in focus: indoleamine 2,3-dioxygenase. Int J Biochem Cell Biol 2007; 39: 2167-2172.
3. Takikawa O, Yoshida R, Kido R, Hayaishi O. Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem 1986; 261: 3648-3653.
4. Ball HJ, Sanchez-Perez A, Weiser S, Austin CJ, Astelbauer F, Miu J et al. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene 2007; 396: 203-213.
5. Brandacher G, Margreiter R, Fuchs D. Implications of IFN-gamma-mediated tryptophan catabolism on solid organ transplantation. Curr Drug Metab 2007; 8: 273-282.
6. Kamimura S, Eguchi K, Yonezawa M, Sekiba K. Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta. Acta Med Okayama 1991; 45: 135-139.
7. Taylor MW, Feng GS. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 1991; 5: 2516-2522.
8. Yoshida R, Nukiwa T, Watanabe Y, Fujiwara M, Hirata F, Hayaishi O. Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice. Arch Biochem Biophys 1980; 203: 343-351.
9. Yoshida R, Urade Y, Tokuda M, Hayaishi O. Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection. Proc Natl Acad Sci USA 1979; 76: 4084-4086.
10. Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004; 4: 762-774.
11. Mellor AL, Munn DH. Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 1999; 20: 469-473.
12. Munn DH, Pressey J, Beall AC, Hudes R, Alderson MR. Selective activation-induced apoptosis of peripheral T cells imposed by macrophages. A potential mechanism of antigen-specific peripheral lymphocyte deletion. J Immunol 1996; 156: 523-532.
13. Hwu P, Du MX, Lapointe R, Do M, Taylor MW, Young HA. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 2000; 164: 3596-3599.
14. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999; 189: 1363-1372.
15. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281: 1191-1193.
16. Frumento G, Rotondo R, Tonetti M, Damonte G, Benatti U, Ferrara GB. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med 2002; 196: 459-468.
17. Terness P, Bauer TM, Rose L, Dufter C, Watzlik A, Simon H et al. Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 2002; 196: 447-457.
18. Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006; 176: 6752-6761.
19. Miki T, Sun H, Lee Y, Tandin A, Kovscek AM, Subbotin V et al. Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. Transplant Proc 2001; 33: 129-130.
20. Alexander AM, Crawford M, Bertera S, Rudert WA, Takikawa O, Robbins PD et al. Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 2002; 51: 356-365.
21. Beutelspacher SC, Pillai R, Watson MP, Tan PH, Tsang J, McClure MO et al. Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression. Eur J Immunol 2006; 36: 690-700.
22. Guillonneau C, Hill M, Hubert FX, Chiffoleau E, Herve C, Li XL et al. CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase. J Clin Invest 2007; 117: 1096-1106.
23. Li Y, Tredget EE, Ghaffari A, Lin X, Kilani RT, Ghahary A. Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute. J Invest Dermatol 2006; 126: 128-136.
24. Marshall B, Keskin DB, Mellor AL. Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme. BMC Biochem 2001; 2: 5.
25. Baban B, Chandler P, McCool D, Marshall B, Munn DH, Mellor AL. Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J Reprod Immunol 2004; 61: 67-77.
26. Milland J, Taylor SG, Dodson HC, McKenzie IF, Sandrin MS. The cytoplasmic tail of alpha 1,2-fucosyltransferase contains a sequence for Golgi localization. J Biol Chem 2001; 276: 12012-12018.
27. Suzuki S, Tone S, Takikawa O, Kubo T, Kohno I, Minatogawa Y. Expression of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase in early concepti. Biochem J 2001; 355: 425-429.