Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome

Journal of Gastrointestinal and Liver Diseases

Volumn 17, Issue 2, 2008, Pages 193-198

  Garruti, Gabriella ^a   Cotecchia, Susanna ^b,c   Giampetruzzi, Federica ^a   Giorgino, Francesco ^a   Giorgino, Riccardo ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Adrenergic receptors; Metabolic syndrome; Obesity; Prohormone convertase 1 3; Sympathetic nervous system; Type 4 melanocortin receptor

Indexed keywords

ADRENERGIC RECEPTOR; GHRELIN; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; NEUROPEPTIDE Y; PROPROTEIN CONVERTASE 1; RECEPTOR SUBTYPE;

ADIPOSE TISSUE; ADRENERGIC SYSTEM; DIGESTIVE SYSTEM FUNCTION DISORDER; FOOD INTAKE; GASTROINTESTINAL TRACT; GENE MUTATION; HUMAN; HYPERPHAGIA; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID STORAGE; LIPOLYSIS; METABOLIC SYNDROME X; NEUROENDOCRINE SYSTEM; NEUROTRANSMITTER RELEASE; OBESITY; PHENOTYPE; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; STRESS;

ADIPOSE TISSUE; EATING; HUMANS; METABOLIC SYNDROME X; NEUROSECRETORY SYSTEMS; OBESITY; PROPROTEIN CONVERTASE 1; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, ADRENERGIC; SYMPATHETIC NERVOUS SYSTEM;

EID: 46449127410     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Arora S, Anubhuti. Role of ncuropeptides in appetite regulation and obesity-a review. Neuropeptides 2006; 40: 375-401.
2. Bouillaud F, Villarroya F, Hentz E, Raimbault S, Cassard AM, Ricquier D. Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe. Clin Sci (London) 1988; 75: 21-27.
3. Garruti G, Ricquier D. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int J Obes Relat Metab Disord 1992; 16: 383-390.
4. Garruti G, Giusti V, Nussbcrger J, et al. Expression and secretion of atrial natriuretic peptide in human adipose tissue and preadipocytcs. Obesity (Silver Spring) 2007; 15: 2181-2189.
5. Giorgino F, Laviola L, Eriksson JW. Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiol Scand 2005; 183: 13-30.
6. Trayhurn P. Adipose tissue in obesity-an inflammatory issue. Endocrinology 2005; 146: 1003-1005.
7. Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE. Brain adipocytokine action and metabolic regulation. Diabetes 2006; 55 (suppl 2): S145-S154.
8. Giacchetti G, Faloia E, Mariniello B, et al. Overcxpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects. Am J Hypertens 2002; 15:381-388.
9. Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000; 21: 697-738.
10. Montague CT, Farooqui IS, Whitehcad JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
11. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 18: 213-215.
12. Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110: 227-239.
13. International Diabetes Federetion Launches First Global Guideline for Management of Type 2 Diabetes. Asianet 2005. 09. 14.
14. Brochu M, Starling RD, Tchernof A, Matthews DE, Garcia-Rubi E, Poehlman ET. Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. J Clin Endocrinol Metab 2000; 85: 2378-2384.
15. Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 2000; 278: E941-E948.
16. Raji A, Seely EW, Arky RA, Simonson DC. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 2001; 86: 5366-5371.
17. Ross R, Freeman J, Hudson R, Janssen I. Abdominal obesity, muscle composition, and insulin resistance in premenopausal women. J Clin Endocrinol Metab 2002; 87: 5044-5051.
18. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Grundy SM. Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest. 1995; 96: 88-98.
19. Garcnc C, Perusse L, Chagnon YC, et al. Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study. Obes Res 2003; 11:612-618.
20. Eriksson P, Dahlman I, Ryden M, Hoffstedt J, Arner P. Relationship between beta-2 adrcnoceptor gene haplotypes and adipocyte lipolysis in women. Int J Obes Relat Metab Disord 2004; 28: 185-190.
21. Lafontan M, Berlan M. Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol Sci 2003; 24: 276-283.
22. Hellmer J, Marcus C, Sonnenfeld T, Amer P. Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J Clin Endocrinol Metab 1992; 75: 15-20.
23. Pedersen SB, Kristensen K, Hermann PA, Katzenellenbogcn JA, Richelsen B. Estrogen controls lipolysis by up-regulating alpha2A-adrcnergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J Clin Endocrinol Metab 2004; 89: 1869-1878.
24. Burcelin R, Uldry M, Foretz M, et al. Impaired glucose homcostasis in mice lacking the alphalb-adrenergic receptor subtype. J Biol Chem 2004; 279: 1108-1115.
25. Eikelis N, Schlaich M, Aggarwal A, Kaye D, Esler M. Interactions between leptin and the human sympathetic nervous system. Hypertension 2003; 41: 1072-1079.
26. Imai J, Katagiri H, Yamada T, et al. Cold exposure suppresses serum adiponcctin levels through sympathetic nerve action activation in mice. Obesity (Silver Spring) 2006; 14: 1132-1141.
27. Kieier F, Kap YS, Mettenleiter TC, et al. Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology 2006; 147: 1140-1147.
28. Kuo LE, Kitlinska JB, Tilan JU, et al. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 2007; 13: 803-811.
29. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997; 385: 165-168.
30. Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-141.
31. Farooqi IS, Yeo GS, Keogh JM, et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest. 2000; 106: 271-279.
32. Chaki S, Okuyama S. Involvement of melanocortin-4 receptor in anxiety and depression. Peptides 2005; 26: 1952-1964.
33. Stütz AM, Staszkiewicz J, Ptitsyn A, Argyropoulos G. Circadian expression of genes regulating food intake. Obesity (Silver Spring) 2007; 15: 607-615.
34. Farooqi IS, Volders K, Stanhope R, et al. Hyperphagia and early onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3. J Clin Endocrinol Metab 2007; 92: 3369-3373.