Effect of sildenafil citrate on interleukin-1β-induced nitric oxide synthesis and iNOS expression in SW982 cells

Experimental and Molecular Medicine

Volumn 40, Issue 3, 2008, Pages 286-293

  Kim, Kyung Ok ^b   Park, Shin Young ^a   Han, Chang Woo ^a   Hyun, Kee Chung ^a   Ryu, Dae Hyun ^a   Han, Joong Soo ^a  

^a Hanyang University   (South Korea)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cyclic nucleotide phosphodiesterases, type 5; Interleukin 1 ; Nitric oxide; Nitric oxide synthase type II; Sildenafil

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; 8 BROMO CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOBUTYLMETHYLXANTHINE; NITRIC OXIDE; NITRITE; RECOMBINANT INTERLEUKIN 1BETA; RNA; ROLIPRAM; SILDENAFIL; TREQUINSIN;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIAL SARCOMA; SYNOVIOCYTE; SYNOVIUM; WESTERN BLOTTING;

EID: 46449092458     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2008.40.3.286     Document Type: Article

References (29)

1. Arend WP, Daye JM. Cytokines and cytokine inhibitor or antagonists in rheumatoid arthritis. Arthritis Rhuem 1995;38:151-60
2. Bredet DS, Snyder SH. Nitric oxide; a physiological messenger molecule. Annul Rev Biochem 1994;63:175-95
3. Corbin JD, Francis SH. Cyclic GMP phosphodiesterase-5; target of Sildenafil. J Biol Chem 1999;274:13729-32
4. Dousa TP. Cyclic-3′-5′-nucleotide phosphodiesterase isozymes in cell biology and patho-physiology of the kidney. Kidney Int 1999;55:29-62
5. Firestein GS, Alvaro-Garcia JM, Maki R. Quanitative analysis of cytokine gene expression in rheumatoid Arthritis. J Immunol 1990;144:3347-53
6. Geng Y, Zhou L, Thompson WJ, Lotz M. Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes. J Biol Chem 1998;273:27484-91
7. Grabowski PS, England AJ, Dykhuizen R, Copland M, Benjamin N, Reid DM, Ralston SH. Elevated nitric oxide production in rheumatoid arthritis. Arthritis Rheum 1996;39:643-7
8. Grabowski PS, Wrigh PK, Van't Hof RJ, Helfrich MH, Ohshima H, Ralston SH. Immuno-localization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis. Br J Rheumatol 1997;36:51-5
9. Hall IP. Multiple conformations of Phsophodiesterase-5. Br J Clin Pharmacol 1993;35:1-7
10. Harris ED. Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med 1990;322:1277-89
11. Hilliquin P, Borderie D, Hernvann A, Menkes CJ, Ekindjian OG. Nitric oxide as S-nitrosoproteins in rheumatoid arthritis. Arthritis Rheum 1997;40:1512-7
12. Jeong JG, Kim JM, Cho H, Hahn W, Yu SS, Kim S. Effects of IL-1β on gene expression in human rheumatoid synovial fibroblasts. Biochem Biophy Res Commun 2004;324:3-7
13. Juilfs DM, Soderling S, Burns F, Beavo JA. Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). Rev Physiol Biochem Pharmacol 1999;135:67-104
14. Koesling D, Friebe A. Soluble guanylyl cyclase: structure and regulation. Rev Physiol Biochem Pharmacol 1999;135:41-65
15. Kurt M, Bilge SS, Aksoz E, Kukula O, Celik S, Kesim Y. Effect of sildenafil on anxiety in the plus-maze test in mice. Pol J Pharmacol 2001;56:353-7
16. LeGrand A, Fermor B, Fink C, Pisetsky DS, Weinberg JB, Vail TP, Guilak F. Interleukin-1, tumor necrosis factor ?, and interleukin-17 synergistically up-regulate nitric oxides and prostaglandin E2 production in explants of human osteoarthritic knee menisci. Arthritis Rheum 2001;44:2078-83
17. McInnes IB, Leung BP, Field M, Wei XQ, Huang FP, Sturrock RD, Kinninmonth A, Weidner J, Mumford R, Liew FY. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J Exp Med 1996;184:1519-24
18. Moreira SG Jr, brannigan RE, Spitz A, Orejuela FJ, Lipshultz LI, Kim ED. Side effect profile of sildenafil citrate (Viagra) in clinical practice. Urology 2000;56:474-6
19. Moreland RB, Goldsrein I, Kim NN, Traish A. Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: Research and clinical implications in erectile dysfunction. TEM 1999;10:97-104
20. Moro MA, Russel R, Cell S, Lizasoain I, Su Y, Darley-Usmar VM, Radomski MW, Moncada S. cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. Proc Natl Aca Sci USA 1996;93:1480-5
21. Mullershausen F, Friebe A, Feil R, Tompson WJ, Hofmann F, Koesling D. Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling. J Cell Biol 2003;160:719-27
22. Nakayamada S, Kurose H, Saito K, Mogami A, Tanaka Y. Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts. Arthritis Res Ther 2005;7:476-84
23. Riku K, Aleksi L, Hannu K, Eeva M. Nitric Oxide Production and Signaling in Inflammation. Curr Drug Targets Inflamm Allergy 2005;4:471-9
24. Rutten K, Prickaerts J, Hendrix M, Van der Staay FJ, Sik A, Blokland A. Time-dependent involvement of cAMP and cGMP in consolidation of object memory: Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors. Eur J Pharmacol 2007;558:107-12
25. Sakurai H, Kohsaka H, Liu MF, Higashiyama H, Hirata Y, Kanno K, Saito I, Miyasaka N. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritis. J Clin Invest 1995;96:2357-63
26. Schmidt HH, Walter U. NO at work. Cell 1994:78:919-25
27. Soderling SH, Beavo JA. Regulaion of cAMP and cGMP signaling; new phosphodiesterases and new functions. Curr Opin Cell Biol 2000;12:174-179
28. Veluthakal R, Amin R. Interleukin-1 beta induces posttranslational carboxylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells. Am J Physiol Cell Physiol 2004;287:1152-62
29. Volke V, Wegener G, Vasar E. Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice. J Physiol Pharmacol 2003;54:653-60