The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes

Journal of Cellular Biochemistry

Volumn 104, Issue 1, 2008, Pages 237-250

  Li, Hui ^a   Liu, Han ^a   Wang, Zimei ^a   Liu, Xinhua ^a   Guo, Liyuan ^a   Huang, Lijun ^a   Gao, Libo ^a   McNutt, Michael A ^a   Li, Gang ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Expression; Lymphocytes; Morphine; Mu opioid receptor; Promoter; Transcription factors

Indexed keywords

MORPHINE; MU OPIATE RECEPTOR; NALOXONE; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR YY1; OPRM1 PROTEIN, HUMAN; YY1 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ARTICLE; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LYMPHOCYTE; MOLECULAR DYNAMICS; MOLECULAR PROBE; MORPHINE ADDICTION; MORPHINE TOLERANCE; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RECEPTOR GENE; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION INITIATION; BINDING SITE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY;

BINDING SITES; HUMANS; LYMPHOCYTES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECEPTORS, OPIOID, MU; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; YY1 TRANSCRIPTION FACTOR;

EID: 46449090418     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21616     Document Type: Article

References (45)

1. Andria ML, Simon EJ. 1999. Localization of promoter elements in the human mu-opioid receptor gene and regulation by DNA methylation. Brain Res Mol Brain Res 70:54-65.
2. Bauknecht T, Jundt F, Herr I, Oehler T, Delius H, Shi Y, Angel P, Zur Hausen H. 1995. A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J Virol 69:1-12.
3. Beagles K, Wellstein A, Bayer B. 2004. Systemic morphine administration suppresses genes involved in antigen presentation. Mol Pharmacol 65:437-442.
4. Börner C, Stumm R, Höllt V, Kraus J. 2007. Comparative analysis of mu-opioid receptor expression in immune and neuronal cells. J Neuroimmunol 188:56-63.
5. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
6. Breslin MB, Vedeckis WV. 1998. The human glucocorticoid receptor promoter upstream sequences contain binding sites for the ubiquitous transcription factor, Yin Yang 1. J Steroid Biochem Mol Biol 67:369-381.
7. Cadet P. 2004. Mu opioid receptor subtypes. Med Sci Monit 10:MS28-M32.
8. Choe CY, Im HG, Ko JL, Loh HH. 1998. Mouse μ opioid receptor gene expression. J Biol Chem 273:34926-34932.
9. Choi HS, Hwang CK, Kim CS, Song KY, Law PY, Wei LN, Loh HH. 2005. Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene. Mol Pharmacol 67:1674-1683.
10. Emanuele DR, Giuseppe P, Olga CV, Elena B. 1998. The binding sites for Xenopus laevis FIII/YY1 in the first exon of L1 and L14 ribosomal protein genes are dispensable for promoter expression. Eur J Biochem 255:563-569.
11. Gill G, Tjian R. 1992. Eukaryotic coactivators associated with the TATA box binding protein. Curr Opin Genet Dev 2:236-242.
12. Goffart S, Wiesner RJ. 2003. Regulation and coordination of nuclear gene expression during mitochondrial biogenesis. Exp Physiol 88:33-40.
13. Hu S, Sheng WS, Lokensgard JR, Peterson PK. 2005. Morphine potentiates HIV-1 gp120-induced neuronal apoptosis. J Infect Dis 191:886-889.
14. Javahery R, Khachi A, Lo K, Zenzie Gregory B, Smale ST. 1994. DNA sequence requirements for transcriptional initiator activity in mammalian cells. Mol Cell Biol 14:116-127.
15. Ko JL, Liu HC, Minnerath SR, Loh HH. 1998. Transcriptional regulation of mouse μ-opioid receptor gene. J Biol Chem 273:27678-27685.
16. Koga T, Suicol AM, Nakamura H, Taura M, Lu Z, Shuto T, Okiyoneda T, Kai H. 2005. Sp1 dependent regulation of Myeloid Elf-1 like factor in human epithelial cells. FEBS Lett 579:2811-2816.
17. Lee JS, Galvint KM, Shit YS. 1993. Evidence for physical interaction between the zinc-finger transcription factors YY1 and Spl. Proc Natl Acad Sci USA 90:6145-6149.
18. Li PF, Hao YS, Huang DA, Liu XH, Liu SL, Li G. 2003. Morphine-promoted survival of CEM x174 cells in early stages of SIV infection in vitro: Involvement of the multiple molecular mechanisms. Toxicol Vitro 18:449-456.
19. Liang Y, Mestek A, Yu L, Carr LG. 1995. Cloning and characterization of the promoter region of the mouse mu opioid receptor gene. Brain Res 679:82-88.
20. Madden JJ, Whaley WL, Ketelsen DK, Donahoe RM. 2001. The morphine-binding site on human activated T-cells is not related to the mu opioid receptor. Drug Alcohol Dependence 62:131-139.
21. Mahajan SD, Schwartz SA, Aalinkeel R, Chawda RP, Sykes DE, Nair MP. 2005. Morphine modulates chemokine gene regulation in normal human astrocytes. Clin Immunol 115:323-332.
22. McCarthy L, Szabo I, Nitsche JF, Pintar JE, Rogers TJ. 2001. Expression of functional mu-opioid receptors during T cell development. J Neuroimmunol 114:173-180.
23. Min BH, Augustin LB, Felsheim RF, Fuchs JA, Loh HH. 1994. Genomicstructure analysis of promotersequence of a mouse opioid receptor gene. Proc Natl Acad Sci USA 91:9081-9085.
24. Nelson BD, Luciakova K, Li R, Betina S. 1995. The role of thyroid hormone and promoter diversity in the regulation of nuclear encoded mitochondrial proteins. Biochim Biophys Acta 1271:85-91.
25. Pampusch MS, Osinski MA, Brown DR, Murtaugh MP. 1998. The porcine mu opioid receptor: Molecular cloning and mRNA distribution in lymphoid tissues. J Neuroimmunol 90:192-198.
26. Pan YX. 2005. Diversity and complexity of the mu opioid receptor gene: Alternative pre-mRNA splicing and promoters. DNA Cell Biol 24:736-750.
27. Papadodima O, Sergaki M, Hurel C, Mamalaki A, Matsas R. 2005. Characterization of the BM88 promoter and identification of an 88 bp fragment sufficient to drive neurone-specific expression. J Neurochem 95:146-159.
28. Royal W, Leander MV, Bissonnette R. 2005. Retinoid-induced mu opioid receptor expression by phytohemagglutinin-stimulated U937 cells. J Neurovirol 11:157-165.
29. Sedqi M, Roy S, Ramakrishnan S, Elde R, Loh HH. 1995. Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages. Biochem Biophys Res Commun 209:563-574.
30. Sui GC, Affar EB, Shi YJ, Brignone C, Wal NR, Yin P, Donohoe M, Luke MP, Calvo D, Grossman SR, Shi Y. 2004. Yin Yang 1 is a negative regulator of p53. Cell 117:859-872.
31. Suzuki S, Miyagi T, Chuang TK, Chuang LF, Doi RH, Chuang RY. 2000. Morphine upregulates mu opioid receptors of human and monkey lymphocytes. Biochem Biophys Res Commun 279:621-628.
32. Suzuki S, Chuang LF, Yau P, Doi RH, Chuang RY. 2002. Interactions of opioid and chemokine receptors: Oligomerization of mu, kappa, and delta with CCR5 on immune cells. Exp Cell Res 280:192-200.
33. Suzuki S, Chuang LF, Doi RH, Chuang RY. 2003. Morphine suppresses lymphocyte apoptosis by blocking p53-mediated death signaling. Biochem Biophys Res Commun 308:802-808.
34. Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ. 2003. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. J Leukoc Biol 74:1074-1082.
35. Thomas MJ, Seto E. 1999. Unlocking the mechanisms of transcription factor YY1 are chromatin modifying enzymes the key. Gene 236:197-208.
36. Waldhoer M, Bartlett SE, Whistler JL. 2004. Opioid receptor. Annu Rev Biochem 73:953-990.
37. Wang JB, Johnson PS, Persico AM. 1994. Hawkins AL, Griffin CA, Uhl GR. cDNA and genomic clones pharmacologic characterization and chromosomal assignment. FEBS Lett 338:217-222.
38. Wang X, Tan N, Douglas SD, Zhang T, Wang YJ, Ho WZ. 2005. Morphine inhibits CD8+ T cell-mediated, non-cytolytic, anti-HIV activity in latently infected immune cells. J Leukoc Biol 78:772-776.
39. Wei EM, Li PF, Liu XH, Qian CW, Li H, Xia WY, Li G. 2005. The potential promoter regions on the 5′-flanking sequence of the mu opioid receptor gene in lymphocytes. J Cell Biochem 95:1204-1213.
40. Wendel B, Hoehe MR. 1998. The human mu opioid receptor gene: 5′ regulatory and intronic sequences. J Mol Med 76:525-532.
41. Xia T, Zeng G, Gao L, Yu RK. 2005. Sp1 and AP2 enhance promoter activity of the mouse GM3-synthase gene. Gene 351:109-118.
42. Xu YH, Carr LG. 2000. Functional characterization of the promoter region of the human μ opioid receptor (hMOR) gene; identification of activating and inhibitory regions. Cell Mol Biol 47:OL29-OL38.
43. Xu J, Li PF, Liu XH, Li G. 2004. Morphine aggravates the apoptosis of simian immunodeficiency virus infected CEM x174 cells in the prolonged culture in vitro. Int Immunopharmacol 4:1805-1816.
44. Yin N, Wang D, Zhang H, Yi X, Sun XJ, Shi B, Wu JH, Wu G, Wang XJ, Shang YF. 2004. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res 64:5870-5875.
45. Zaid A, Li R, Luciakova K, Barath P, Nery S, Nelson BD. 1999. On the role of the general transcription factor Sp1 in the activation and repression of diverse mammalian oxidative phosphorylation genes. J Bioenerg Biomembr 31:129-135.