The potential promoter regions on the 5′ flank sequence of the mu opioid receptor gene in lymphocytes

Journal of Cellular Biochemistry

Volumn 95, Issue 6, 2005, Pages 1204-1213

  Wei, Erman ^a   Li, Pingfeng ^a   Liu, Xinhua ^a   Qian, Chaowei ^a   Li, Hui ^a   Xia, Weiyi ^a   Li, Gang ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Expression; Lymphocytes; Morphine; Mu opioid receptor; Transcription initiation site; Transcriptional regulation

Indexed keywords

MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; OPIATE ANTAGONIST;

ARTICLE; DOSE RESPONSE; ENHANCER REGION; GENE; GENE EXPRESSION REGULATION; GENE MAPPING; HUMAN; IMMUNOCOMPETENT CELL; LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

5' FLANKING REGION; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; GENE EXPRESSION; HUMANS; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; PLASMIDS; PROMOTER REGIONS (GENETICS); RECEPTORS, OPIOID, MU; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 26444571458     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20529     Document Type: Article

References (34)

1. Andria ML, Simon EJ. 1999. Localization of promoter elements in the human mu-opioid receptor gene and regulation by DNA methylation. Brain Res Mol Brain Res 70:54-65.
2. Bogomolski-Yahalom V, Klein A, Greenblat I, Haviv T, Tur-Kaspa R. 1997. The TATA-less promoter of hepatitis B virus S gene contains a TBP binding site and an active initiator. Virus Res 49:1-7.
3. Cadet P. 2004. Mu opiate receptor subtypes. Med Sci Monit 10:MS28-32.
4. Donahoe RM, Vlahov D. 1998. Opiates as potential cofactors in progression of HIV-1 infections to AIDS. J Neuroimmunol 83:77-87.
5. Gavériaux C, Peluso J, Simonin F, Laforet J, Kieffer B. 1995. Identification of k- and d-opioid receptor transcrips in immune cells. FEES Lett 369:272-276.
6. Gopalkrishnan RV, Lam EWF, Kedinger C. 1998. The p53 tumor suppressor inhibits transcription of the TATA-less mouse DP1 promoter. J Biol Chem 273:10972-10978.
7. Gurwell JA, Nath A, Sun Q, Zhang J, Martin KM, Chen Y, Hauser KF. 2001. Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro. Neuroscience 102:555-563.
8. Hao YS, Zhand FX, Huang DA, Liu XH, Li PF, Li G. 2003. Morphine alleviate the apoptotic progression of the cultured CEM × 174 cells infected with simian immunodeficiency virus in the early stages. Cell Biol Int 27:719-725.
9. Huber R, Schlessinger D, Pilia G. 1998. Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican3 (GPC3) gene. Gene 214:35-44.
10. Janne M, Hammond GL. 1998. Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter. J Biol Chem 273:34105-34114.
11. Ko JL, Liu HC, Minnerath SR, Loh HH. 1998. Transcriptional regulation of mouse mu-opioid receptor gene. J Biol Chem 273:27678-27685.
12. Ko JL, Chen HC, Loh HH. 2002. Differential promoter usage of mouse mu-opioid receptor gene during development. Brain Res Mol Brain Res 104:184-193.
13. Ko JL, Liu HC, Loh HH. 2003. Role of an AP-2-like element in transcriptional regulation of mouse micro-opioid receptor gene. Brain Res Mol Brain Res 112:153-162.
14. Kraus J, Horn G, Zimprich A, Simon T, Mayer P, Holt V. 1995. Molecular cloning and functional analysis of the rat mu opioid receptor gene promoter. Biochem Biophys Res Commun 215:591-597.
15. Li PF, Hao YS, Huang DA, Liu XH, Liu SL, Li G. 2004. Morphine-promoted survival of CEM × 174 cells in early stages of SIV infection in vitro: Involvement of the multiple molecular mechanisms. Toxicology in Vitro 18:449-456.
16. Liang Y, Mestek A, Yu L, Carr LG. 1995. Cloning and characterization of the promoter region of the mouse mu opioid receptor gene. Brain Res 679:82-88.
17. Madden JJ, Whaley WL, Ketelsen DK, Donahoe RM. 2001. The morphine-binding site on human activated T-cells is not related to the mu opioid receptor. Drug Alcohol Dependence 62:131-139.
18. McCarthy L, Szabo I, Nitsche JF, Pintar JE, Rogers TJ. 2001. Expression of functional mu-opioid receptors during T cell development. J Neuroimmunol 114:173-180.
19. Min BH, Augustin LB, Felsheim RF, Fuchs JA, Loh HH. 1994. Genomic structure analysis of promoter sequence of a mouse opioid receptor gene. Proc Natl Acad Sci USA 91:9081-9085.
20. Nair MP, Schwartz SA, Polasani R, Hou J, Sweet A, Chadha KC. 1997. Immunoregulatory effects of morphine on human lymphocytes. Clin Diagn Lab Immunol 4:127-132.
21. Pampusch MS, Osinski MA, Brown DR, Murtaugh MP. 1998. The porcine mu opioid receptor: Molecular cloning and mRNA distribution in lymphoid tissues. J Neuroimmunol 90:192-198.
22. Raghavendra V, Singh V, Kulkarni SK, Agrewala JN. 2001. Melatonin enhances Th2 cell mediated immune responses: Lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists. Mol Cell Biochem 221:57-62.
23. Salter RD, Howell DN, Cresswell P. 1985. Genes regulating HLA class 1 antigen expression in T-B lymphoblast hybrids. Immunogenetics 21:235-246.
24. Singhal PC, Kapasi AA, Reddy K, Franki N, Gibbons N, Ding G. 1999. Morphine promotes apoptosis in Jurkat cells. J Leukoc Biol 66:650-658.
25. Steele AD, Henderson EE, Rogers TJ. 2003. Mu-opioid modulation of HIV-1 coreceptor expression and HIV-1 replication. Virology 309:99-107.
26. Suzuki S, Miyagi T, Chuang TK, Chuang LF, Doi RH, Chuang RY. 2000. Morphine upregulates mu opioid receptors of human and monkey lymphocytes. Biochem Biophysic Res Comm 279:621-628.
27. Suzuki S, Chuang LF, Yau P, Doi RH, Chuang RY. 2002. Interactions of opioid and chemokine receptors: Oligomerization of mu, kappa, and delta with CCR5 on immune cells. Exp Cell Res 280:192-200.
28. Suzuki S, Chuang LF, Doi RH, Chuang RY. 2003. Morphine suppresses lymphocyte apoptosis by blocking p53-mediated death signaling. Biochem Biophys Res Commun 308:802-808.
29. Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ. 2003. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. J Leukoc Biol 74:1074-1082.
30. Wang J, Charboneau R, Balasubramanian S, Barke RA. Loh HH, Roy S. 2001. Morphine modulates lymph node-derived T lymphocyte function: Role of caspase-3, -8, and nitric oxide. J Leukoc Biol 70:527-536.
31. Wang J, Charboneau R, Balasubramanian S, Barke RA, Loh HH, Roy S. 2002. The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. J Leukoc Biol 71:782-790.
32. Wendel B, Hoehe MR. 1998. The human mu opioid receptor gene: 5′ regulatory and intronic sequences. J Mol Med 76:525-532.
33. Wick MJ, Minnerath SR, Roy S, Ramakrishnan S, Loh HH. 1996. Differential expression of opioid recptor genes in human lymphoid cells lines and peripheral blood lymphocytes. J Neuroimmunol 64:29-36.
34. Xu YH, Carr LG. 2000. Functional characterization of the promoter region of the human μ opioid receptor (hMOR) gene; identification of activating and inhibitory regions. Cellular Mol Biol 47:OL29-OL38.