C825T polymorphism of the G-protein β3 subunit gene and atrial fibrillation: Association of the TT genotype with a reduced risk for atrial fibrillation

American Heart Journal

Volumn 148, Issue 3, 2004, Pages 545-550

  Schreieck, Juergen ^a,b   Dostal, Stefan ^a   Von Beckerath, Nicolas ^a   Wacker, Annette ^a   Flory, Michelle ^a   Weyerbrock, Sonja ^a   Koch, Werner ^a   Schömig, Albert ^a   Schmitt, Claus ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

ADULT; AGED; ARTICLE; BODY MASS; CARDIOMYOPATHY; CARDIOVASCULAR RISK; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEALTH CENTER; HEART ATRIUM FIBRILLATION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INCIDENCE; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUPRAVENTRICULAR TACHYCARDIA; VALVULAR HEART DISEASE;

ATRIAL FIBRILLATION; FEMALE; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK;

EID: 4644356747     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ahj.2004.03.024     Document Type: Article

References (33)

1. Benjamin E.J., Wolf P.A., D'Agostin R.B., et al. Impact of atrial fibrillation on the risk of death the Framingham Heart Study. Circulation. 98:1998;46-52
2. Kannel W.B., Wolf P.A., Benjamin E.J., et al. Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation population-based estimates. Am J Cardiol. 16:1998;2N-9N
3. Brugada R., Tapscott T., Czernuszewisz G.Z., et al. Identification of a genetic locus for familial atrial fibrillation. N Engl J Med. 336:1997;905-911
4. Chen Y.H., Xu S.J., Bendahhou S., et al. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science. 299:2003;251-254
5. Lai L.P., Su M.J., Yeh H.M., et al. Association of the human minK gene 38G allele with atrial fibrillation evidence of possible genetic control on the pathogenesis of atrial fibrillation. Am Heart J. 144:2002;485-490
6. Ogimoto A., Hamada M., Nakura J., et al. Relation between angiotensin-converting enzyme II genotype and atrial fibrillation in Japanese patients with hypertrophic cardiomyopathy. J Hum Genet. 47:2002;184-189
7. Yamashita T., Hayami N., Ajiki K., et al. Is ACE gene polymorphism associated with lone atrial fibrillation? Jpn Heart J. 38:1997;637-641
8. 3- subunit 825T allele is associated with enhanced human atrial inward rectifier potassium currents. Circulation. 8:2000;692-697
9. Siffert W., Rosskopf D., Siffert G., et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet. 18:1998;45-48
10. Rosskopf D., Manthey I., Habich C., et al. Identification and characterization of Gbeta3s2, a novel splice variant of the G-protein beta3 subunit. Biochem J. 371:2003;223-232
11. 3-subunit implicated in disease states does not modulate ion channels. Physiol Genomics. 13:2003;85-95
12. 3-subunit implicated in disease states does not modulate ion channels." Physiol Genomics. 13:2003;81-84
13. Siffert W. Molecular genetics of G proteins and atherosclerosis risk. Basic Res Cardiol. 96:2001;606-611
14. Dobrev D., Graf E.M., Ravens U. G-protein ß3-subunit gene status is associated with different expression of potassium channels in chronic atrial fibrillation (Abstract). Circulation. 106:(suppl II):2002;II-257
15. + channel response to acetylcholine and to G protein-mediated activation in atrial myocytes isolated from failing human hearts. Circulation. 90:1994;2213-2224
16. Dobrev D., Graf E., Wettwer E., et al. Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current I(K,Ach) in chronic human atrial fibrillation decrease in GIRK4 mRNA correlates with reduced I(K,Ach) and muscarinic receptor-mediated shortening of action potentials. Circulation. 104:2001;2551-2557
17. Dobrev D., Wettwer E., Kortner A., et al. Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovasc Res. 54:2002;397-404
18. Tabara Y., Kohara K., Miki T. Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. J Hypertens. 20:2002;651-656
19. Sahn D.J., De Maria A., Kisslo J., et al. The Committee on M-mode standardization of the American Society recommendations regarding quantitation in M-mode echocardiography. Circulation. 58:1978;1071-1083
20. World Health Organization Study Group. Diabetes mellitus. WHO Tech Rep Ser. 727:1985;101-104
21. Guidelines Subcommittee. 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. J Hypertens. 17:1999;151-183
22. Livak K.J. Allelic discrimination using fluorogenic probes and the 5′nuclease assay. Genet Anal. 14:1999;143-149
23. 3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and black African individuals. J Am Soc Nephrol. 10:1999;1921-1930
24. Beige J, Hohenbleicher H, Distler A, et al. G-Protein beta3 subunit C825T variant and ambulatory blood pressure in essential hypertension. Hypertension 1999;33:1049-51
25. Benjafield A.V., Jeyasingam C.L., Nyholt D.R., et al. G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension. 32:1998;1094-1097
26. 3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension. 32:1998;510-513
27. 3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. Cardiovasc Res. 49:2001;820-827
28. 3 subunit gene variant and left ventricular hypertrophy in essential hypertension. Hypertension. 35:2000;214-218
29. Von Beckerath N., Schusterschitz Y., Koch W., et al. G protein beta 3 subunit 825T allele carriage and risk of coronary artery disease. Atherosclerosis. 167:2003;135-139
30. Bosch R.F., Nattel S. Cellular electrophysiology of atrial fibrillation. Cardiovasc Res. 54:2002;259-269
31. Dobrev D., Ravens U. Remodeling of cardiomyocytes ion channels in human atrial fibrillation. Basic Res Cardiol. 98:2003;137-148
32. Hirose M., Carlson M.D., Laurita K.R. Cellular mechanisms of va-gally mediated atrial tachyarrhythmia in isolated arterially perfused canine right atria. J Cardiovasc Electrophysiol. 13:2002;918-926
33. Coumel P. Autonomic influences in atrial tachyarrhythmias. J Cardiovasc Electrophysiol. 7:1996;999-1007