Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditions

British Journal of Pharmacology

Volumn 143, Issue 1, 2004, Pages 166-178

  Nobe, Koji ^a   Miyatake, Mari ^a   Nobe, Hiromi ^a   Sakai, Yasushi ^a   Takashima, Junko ^b   Momose, Kazutaka ^a  

^a SHOWA UNIVERSITY   (Japan)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

Author keywords

High glucose; Mouse aorta; Phosphatidylinositol turnover; Porcine coronary artery; Protein kinase C; Vascular smooth muscle

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 6 [2 [4 [(4 FLUOROPHENYL)PHENYLMETHYLENE] 1 PIPERIDYL]ETHYL] 7 METHYL 5H THIAZOLO[3,2 A]PYRIMIDIN 5 ONE; CALCIUM; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE INHIBITOR; GLUCOSE; PHOSPHOLIPASE C; PROTEIN KINASE C; STEMPHONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTERY CONSTRICTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DIABETES MELLITUS; DRUG EFFICACY; DRUG SELECTIVITY; ENZYME ACTIVATION; HYPERGLYCEMIA; MALE; MOUSE; NONHUMAN; PORTAL VEIN; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SWINE; VENOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; AORTA, THORACIC; BENZOQUINONES; DIACYLGLYCEROL KINASE; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCOSE; ISOMETRIC CONTRACTION; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHOSPHOLIPASE C; PORTAL VEIN; SUBCELLULAR FRACTIONS; VASOCONSTRICTOR AGENTS;

EID: 4644303548     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705910     Document Type: Article

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